Eccrine Spiradenoma: A Pharmacologic Study

Multiple vascular eccrine spiradenomas: A case report and published work review of multiple eccrine spiradenomas

“…A total of 35 cases of multiple ES have been described in 26 other reports between 1956 and 2008 (Table 1). 1,2,8–31 With solitary ES, there is a male preponderance with a male : female ratio of 2:1 1 . With multiple ES, 27 of the reported 35 cases were women (male : female ratio 1:3).…”

Painful Tumors of the Skin

“…They hypothesized that the stroma was a buffer to nerve stimulation and that the pain was related to the distribution of sensory nerves within stroma 8 . Berghorn et al 12 demonstrated production of pain in eccrine spirad‐enoma with intralesional acetylcholine injections and blockage of the pain with atropine. They hypothesized that, similar to the secretory response of eccrine cells to acetylcholine, the tumor cells respond to acetylcholine (released from nerves surrounding the tumor) with trans‐location of fluid, subsequent distention of the innervated tumor capsule, and pain 11,12 .…”

“…Berghorn et al 12 demonstrated production of pain in eccrine spirad‐enoma with intralesional acetylcholine injections and blockage of the pain with atropine. They hypothesized that, similar to the secretory response of eccrine cells to acetylcholine, the tumor cells respond to acetylcholine (released from nerves surrounding the tumor) with trans‐location of fluid, subsequent distention of the innervated tumor capsule, and pain 11,12 . Stegmaier and Kersting 13 demonstrated production of pain in eccrine spiradeno‐mas with oxytocin injection adjacent to the tumor, and hypothesized the presence of a contractile tissue, either vasculature or myoepithelium, in eccrine spiradenoma.…”

Multiple eccrine spiradenoma: case report and review

“…Since then, a second large series of patients (2) and reports of multiple eases have appeared. Most eccrine spiroadenomas are solitary tumors, howewer, multifocal or multiple lesions have been reported (3)(4)(5)(6)(7)(8)(9)(10). We report an unusual case of multiple ES occurring on the scalp in random distribution, mimicking multiple cylindroma.…”

“…It was first described by Kersting and Helwig in 1956 (1). Most eccrine spiroadenomas are solitary tumors, howewer, multifocal or multiple lesions have been reported (3)(4)(5)(6)(7)(8)(9)(10). Most eccrine spiroadenomas are solitary tumors, howewer, multifocal or multiple lesions have been reported (3)(4)(5)(6)(7)(8)(9)(10).…”