Eccrine Porocarcinoma (Malignant Eccrine Poroma): A Series of Eight Challenging Cases

Luz, Murilo de Almeida; Ogata, Daniel Cury; Montenegro, Marcos Flávio; Biasi, L.; Ribeiro, Leandro Carvalho

doi:10.1590/s1807-59322010000700014

Cited by 45 publications

(45 citation statements)

References 16 publications

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“…Although some large case series of EPC have been published [2, 3, 4, 5, 6, 7, 8, 9, 10, 11], the biological behavior of this entity has not been fully elucidated. Accurate diagnosis, optimal treatment, and prognosis of EPC are still challenging due to the paucity of data concerning this condition.…”

Section: Introductionmentioning

confidence: 99%

Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases

Kurashige

Minemura

Nagatani³

2013

Case Rep Dermatol

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Background: Eccrine porocarcinoma (EPC), a slow-growing carcinoma of the sweat gland, is a rare condition documented only in a small number of case series. Due to its rarity, guidelines and specific recommendations are not widely available. Accordingly, many dermatologists encounter difficulty in diagnosing and treating EPC. The aim of this study is to report the clinical and pathological features of EPC in order to contribute to the body of information currently available on the subject. Patients and Methods: From 2003 to 2013, 8 Japanese patients were diagnosed with EPC at the Department of Dermatology in the Hachioji Medical Center of Tokyo Medical University. Patient data, including clinical manifestations, histopathological findings, immunohistochemical results, treatment method, and clinical course were collected and documented. Results: The mean age of the patients (6 males and 2 females) was 72.6 years. The duration of the lesions ranged from 4 months to 5 years (mean: 3.5 years). All of the lesions clinically presented with erosive reddish nodules (mean size: 39.0 mm). Initial CT imaging revealed that 1 case had multiple distant metastases. Surgical resection was performed for all primary lesions and follow-up observations were available in all cases (mean: 10.9 months). One case with distal metastases underwent both radiation therapy and chemotherapy, but nevertheless succumbed to the disease. Conclusion: The EPC cases in our department presented a versatile clinical appearance and characteristic histopathological features.

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Section: Introductionmentioning

confidence: 99%

Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases

Kurashige

Minemura

Nagatani³

2013

Case Rep Dermatol

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“…They named it epidermotropic eccrine carcinoma. Since then, in literature there have been published numerous case reports [4][5][6][7][8][9][10][11]. Due to the rarity of this oncological entity, accurate data on its incidence, etiopathogenesis, and biological behaviour are quite poor.…”

Section: Discussionmentioning

confidence: 99%

“…The original study series have demonstrated local recurrences in 4.1-35% [4-7, 10, 11] and metastases in 4.1-50% of cases [4][5][6][7][8][9][10]. Despite marked percentage variance, these data suggest that EP is likely an aggressive and prognostically unfavorable type of cutaneous neoplasia.…”

Section: Discussionmentioning

confidence: 99%

Eccrine Porocarcinoma: A Case Report of a Rare Skin Malignancy (Dermatopathologic View)

Bartoš

Kullová

2017

Galician med. j.

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Eccrine porocarcinoma is extremely rare malignant skin adnexal tumor histogenetically derived from the sweat gland ducts and acrosyringium. The authors described a 66-year-old woman, who was diagnosed to have a malignant cutaneous neoplasia arising in the lateral side of the right shin. The lesion displayed exophytic growth with central ulceration, it was rounded and well-defined having 25 mm in diameter. Microscopically, it exhibited a mixture of atypical basaloid and clear cell population arranged in solid-nodular fashion, that grew out from the epidermis and infiltrated the corium. Ductal formations were sporadically present as well. Tumor was immunohistochemically positive for HMWCK, CK7, EMA, weakly positive for pCEA and negative for mCEA and BerEP4. The spectrum of histomorphologic and immunophenotypic findings favored a diagnosis of primary eccrine porocarcinoma. Having made the retrospective analysis, the authors found only this single one biopsy-proven case of EP during the last seven years suggesting exclusive diagnosis in a routine dermatopathologic practice. Keywords

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“…Complete excision has produced cure rates of 70–80% . Optimal margins have been reported as 3 mm, 5 mm, and even 10 mm . Because of the rarity of this type of skin cancer, a consensus as to proper therapy has been suggested but not clearly defined.…”

Section: Discussionmentioning

confidence: 99%