EAU Guidelines on Prostate Cancer

Heidenreich, Axel; Aus, Gunnar; Bolla, M.; Joniau, Steven; Матвеев, В. Б.; Schmid, Hans Peter; Zattoni, F.

doi:10.1016/j.eururo.2007.09.002

Cited by 1,509 publications

(764 citation statements)

References 49 publications

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“…In our study, men with high SES, and in particular men with high income, had significantly shorter waiting times, more frequently received treatment with curative intent, and had better short‐term surgical outcomes. Furthermore, men with high SES and intermediate and high‐risk Pca were more likely to receive curative treatment as recommended by prostate cancer guidelines6, 22, 23 in line with findings in previous studies, for example, men with high SES in the UK and the US were more likely to undergo surgery 24, 25. More men with high SES and very high‐risk Pca in our study received treatment with curative intent than men with low SES, despite the absence of guidelines recommending this treatment.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic status and diagnosis, treatment, and mortality in men with prostate cancer. Nationwide population‐based study

Tomic

Ventimiglia

Robinson

et al. 2018

Intl Journal of Cancer

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Patients with high socioeconomic status (SES) have better cancer outcomes than patients with low SES. This has also been shown in Sweden, a country with tax‐financed health care aiming to provide care on equal terms to all residents. The association between income and educational level and diagnostics and treatment as outlined in national guidelines and prostate cancer (Pca) and all‐cause mortality was assessed in 74,643 men by use of data in the National Prostate Cancer Register of Sweden and a number of other health care registers and demographic databases. In multivariable logistic regression analysis, men with high income had higher probability of Pca detected in a health‐check‐up, top versus bottom income quartile, odds ratio (OR) 1.60 (95% CI 1.45–1.77) and lower probability of waiting more than 3 months for prostatectomy, OR 0.77 (0.69–0.86). Men with the highest incomes also had higher probability of curative treatment for intermediate and high‐risk cancer, OR 1.77 (1.61–1.95) and lower risk of positive margins, (incomplete resection) at prostatectomy, OR 0.80 (0.71–0.90). Similar, but weaker associations were observed for educational level. At 6 years of follow‐up, Pca mortality was modestly lower for men with high income, which was statistically significant for localized high‐risk and metastatic Pca in men with no comorbidities. All‐cause mortality was less than half in top versus bottom quartile of income (12% vs. 30%, p < 0.001) among men above age 65. Our findings underscore the importance of adherence to guidelines to ensure optimal and equal care for all patients diagnosed with cancer.

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Section: Discussionmentioning

confidence: 99%

Socioeconomic status and diagnosis, treatment, and mortality in men with prostate cancer. Nationwide population‐based study

Tomic

Ventimiglia

Robinson

et al. 2018

Intl Journal of Cancer

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“…In many cases, superior oncologic efficacy of one primary management strategy over another has not been established and treatment patterns are thought to reflect a variety of factors, including physician and patient preference. 7,8 Further, men are at risk of treatment-related morbidity which can persist, 9,10 and measures of quality of life outcomes are emerging as potential tools to help guide treatment decisions. 9,[11][12][13] The purpose of this article was to describe how patient demographics, including comorbidity and functional quality of life status, as well as disease characteristics of men with prostate cancer in the United States have changed in the PSA era since 1999.…”

Section: Resultsmentioning

confidence: 99%

Patient Demographics, Quality of Life, and Disease Features of Men With Newly Diagnosed Prostate Cancer: Trends in the PSA Era

Glass

Cowan

Fuldeore

et al. 2013

Urology

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“…1 Together with PSA and digital-rectal examination, the pathology report of the PB provides valuable information for stage prediction and for further therapeutic management of men with PC. 2 PB pathology parameters of relevance for predicting tumour stage and prognosis are Gleason score (including primary and secondary pattern), number of PC-positive biopsy cores and extent of involvement and presence of perineural invasion.…”

Section: Introductionmentioning

confidence: 99%

Prostate cancer at the peripheral end of a prostate biopsy specimen as assessed by a novel marking technique may indicate increased risk of locally advanced disease

Ponholzer

Rauchenwald

Rainer-Concin

et al. 2010

Prostate Cancer Prostatic Dis

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The objective of this study was to test a novel technique of processing a prostate biopsy (PB) specimen by marking its peripheral end (PE) as a predictive tool for locally advanced prostate cancer (PC) or margin-positive resection (R1) after radical prostatectomy (RP). Prospective evaluation of a consecutive cohort of men who underwent PB and subsequent RP was carried out. Transrectal ultrasound-guided 10-20 core PB was performed according to a standardized protocol. Each biopsy core was inked at the PE and classified as PE positive or negative. The study cohort comprised 100 men with a mean age of 62.3 years (41-75 years). Overall, PE-positive cores were found in 71 men, postoperative tumour (pT)3/pT4 stages were diagnosed in 33 men and R1 status in 45 men after RP. In univariate analysis, the presence of at least one PE-positive core was correlated to an increased risk for pT3/pT4 stage (relative risk (RR): 3.15; 95% confidence interval (95% CI): 1.1-9.9; P ¼ 0.03) and R1 status (RR: 2.9; 95% CI: 1.1-7.5; P ¼ 0.03). In multivariate analysis including Gleason score, total number of positive cores, PE positivity and PSA, PE positivity was correlated to pT3/pT4 stage (P ¼ 0.04). In conclusion, PC at the PE of a PB specimen predicts nonorgan-confined tumour stage in subsequent prostatectomy. This simple, new technique may contribute to increasing the accuracy of risk stratification for curative treatment of PC.

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EAU Guidelines on Prostate Cancer

Cited by 1,509 publications

References 49 publications

Socioeconomic status and diagnosis, treatment, and mortality in men with prostate cancer. Nationwide population‐based study

Socioeconomic status and diagnosis, treatment, and mortality in men with prostate cancer. Nationwide population‐based study

Patient Demographics, Quality of Life, and Disease Features of Men With Newly Diagnosed Prostate Cancer: Trends in the PSA Era

Prostate cancer at the peripheral end of a prostate biopsy specimen as assessed by a novel marking technique may indicate increased risk of locally advanced disease

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