Eating disorder animal model

Treasure, Janet; Eid, Laura

doi:10.1097/yco.0000000000000550

Cited by 10 publications

(9 citation statements)

References 79 publications

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“…Understanding the brain mechanisms by which vulnerable individuals develop unmanageable patterns of consumption of food or alcohol is key in order to improve treatments and prevent addiction. Over the last decade an increasing number of studies have used animal models that attempt to mimic binge intake (Thiele and Navarro, 2014;Jeanblanc et al, 2018;Treasure and Eid, 2019). Originally designed to study high voluntary EtOH consumption achieving behaviorally-intoxicating BECs, the DID model has been extensively used to investigate the neurobiology of binge-like EtOH intake (Rhodes et al, 2005;Thiele and Navarro, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure

Morales

Rodríguez-Borillo

Font

et al. 2020

Behavioural Pharmacology

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Chronic alcohol (EtOH) binging has been associated with long-term neural adaptations that lead to the development of addiction. Many of the neurobiological features of EtOH abuse are shared with other forms of binging, like pathological feeding. The drinkingin-the-dark paradigm (DID) has been used extensively to study the neurobiology of EtOH binge-like drinking due to its ability to promote high intakes relevant to human behavior. DID can also generate high consumption of other tastants, but this procedure has not been fully adapted to study forms of binging behavior that are not alcohol-driven. In the present study we used a modified version of DID that uses multiple bottle availability to promote even higher levels of EtOH drinking in male C57BL/6J mice and allows a thorough investigation of tastant preferences. We assessed whether administration of systemic naltrexone (NTX) could reduce binging on EtOH, sucrose, and saccharin separately as well as in combination. Our multiple bottle DID procedure resulted in heightened levels of consumption compared to previously reported data using this task. We found that administration of the opioid receptor antagonist NTX reduced intakes of preferred, highly concentrated EtOH, sucrose, and saccharin. We also report that NTX was able to reduce overall intakes when animals were allowed to self-administer EtOH, sucrose, or saccharin in combination. Our modified DID procedure provides a novel approach to study binging behavior that extends beyond EtOH to other tastants (i.e., sucrose and artificial sweeteners), and has implications for the study of the neuropharmacology of binge drinking.

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Section: Discussionmentioning

confidence: 99%

Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure

Morales

Rodríguez-Borillo

Font

et al. 2020

Behavioural Pharmacology

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“…PR tasks remain the dominant behavioral task in animal studies examining neural regulation of rewarding behavior (Beloate & Coolen, 2017; Lamontagne & Olmstead, 2019; Prieto-Garcia et al, 2015; Robinson et al, 2014; Smith, 2020; Treasure & Eid, 2019). These include studies tracking site-specific influence of dopamine release via use of selective dopamine agonists and antagonists, receptor knock-down models, and optogenetics.…”

Section: The Present Study Aims and Hypothesesmentioning

confidence: 99%

Reliability and validity of a transdiagnostic measure of reward valuation effort.

Keel¹,

Kennedy²,

Rogers³

et al. 2022

Psychological Assessment

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To identify biobehavioral mechanisms underlying excessive reward consumption, reward valuation—effort (RV-E) assessments should (a) parallel measures in basic science to permit translation from preclinical to clinical studies; (b) quantify constructs dimensionally from healthy to disease states; and (c) hold relevance across different diagnostic categories. To address these aims, we developed a progressive ratio (PR) task whereby RV-E is measured as breakpoint when participants worked for access to playing a game. We evaluated test–retest reliability of breakpoint and convergent and discriminant validity of interpretations of this score against an established PR task for food. In Study 1, female undergraduates (N = 71; 33% racial minority; 28% ethnic minority) completed the game and food tasks in fasted and fed states. In Study 2, women (N = 189; 29% racial minority; 27% ethnic minority) with eating disorders (n = 158) were compared to controls (n = 31) on tasks. Game task breakpoint demonstrated excellent test–retest reliability, intraclass correlation coefficient (ICC) = .91, 95% CI [.80, −.96], over 2 weeks and convergent validity with the fasted food task (r = .51, p < .001). Consistent with animal models, breakpoint was lower in fed compared to fasted states across tasks, B (SE) = 321.01 (552.40), p < .001. Finally, the game task demonstrated discriminant validity from measurement of satiation. In Study 2, women with eating disorders demonstrated higher breakpoint on both tasks compared to controls, and game PR task breakpoint decreased from a fasted to fed state. The game PR task offers a novel approach for translating results from animal models of RV-E into testable hypotheses in nonclinical and clinical samples.

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“…An interesting finding pertaining to addiction and eating disorders is food addiction. Two articles mention food addiction as an eating disorder that closely resembles addiction-like behaviour [19,21]. Eating disorders have traditionally been associated with a lack of eating or prolonged starvation for a period of time, however compulsive eating has not been studied as well.…”

Section: Discussionmentioning

confidence: 99%

“…Eating disorders were explored with the use of rat and rodent models in all articles included in this review. Two articles discuss behavioural models and report they are effective in the study of eating disorders [20,21]. Three models discuss neurobiological models [22][23][24], and two articles discuss the etiology and development of eating disorders [25,26].…”

Section: Eating Disordersmentioning

confidence: 99%

Animal Models of Psychiatric Disorders: A Literature Review

Patel

2021

URNCST Journal

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Introduction: Animal models have been used in many areas of research to provide insights into mechanisms and treatments for various disorders and diseases. For example, animals are often used in other areas of psychology, such as learning, with examples such as Pavlov's dogs and Skinner's rats. Further, animals have also been noted to exhibit psychiatric disorders that are frequently observed in humans, such as depression and anxiety. However, the use of animal models in other less studied fields of psychiatric research is unclear. This poses the questions: is the use of animals effective in studies of common mental health disorders? If so, what aspects of common mental health disorders do current studies focus on? Further, can disorders that have lower prevalence rates also be studied with the use of animals? This paper reviews the use of animals in the study of obsessive-compulsive related disorders of addiction, eating disorders, and trichotillomania (a disorder of compulsive hairpulling) to answer these questions. Methods: Addiction, eating disorders, and trichotillomania were examined based on ease of study in non-human animals, and sufficient available literature. Nine articles for each disorder were examined to determine types of animals used, and the purpose of animal models in the study. Results: Research shows animal models are often used to study the etiology, genetics, mechanisms, and neurochemistry of psychiatric disorders. Animal models have high validity and translate well to humans. However, treatments of psychiatric disorders are less studied using animal models. Discussion: The review of the current literature suggests animal models are effective in studies of addiction, eating disorders, and trichotillomania. Animal models can be developed to inform various aspects of psychiatric disorders and should be expanded to include studies examining treatments as well. Further, food addiction also should be further assessed using animal models. Conclusion:Overall, animal models are useful in studying various aspects of psychiatric disorders and should continue to be used for those less commonly studied. Future studies with animal models should focus on psychiatric disorders that involve compulsive, repetitive behaviours.

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Eating disorder animal model

Cited by 10 publications

References 79 publications

Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure

Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure

Reliability and validity of a transdiagnostic measure of reward valuation effort.

Animal Models of Psychiatric Disorders: A Literature Review

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