Eating and healthy ageing: a longitudinal study on the association between food consumption, memory loss and its comorbidities

Xu, Xiaoyue; Ling, Mabel; Inglis, Sally C.; Hickman, Louise; Parker, Deborah

doi:10.1007/s00038-020-01337-y

Cited by 13 publications

(11 citation statements)

References 33 publications

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“…Unpaired student t-Tests were used to compare two groups in existing dataset analysis. A oneway analysis of variance (ANOVA) with Bonferroni comparisons was used to compare between multiple groups [38]. All statistical analyses were performed using GraphPad Prism Software (San Diego, CA, USA) as previously described [39].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis

et al. 2020

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Background: Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus disease-2019 (COVID-19) is a pandemic disease that affects > 2.8 million people worldwide, with numbers increasing dramatically daily. However, there is no specific treatment for COVID-19 and much remains unknown about this disease. Angiotensin-converting enzyme (ACE)2 is a cellular receptor of SARS-CoV-2. It is cleaved by type II transmembrane serine protease (TMPR SS)2 and disintegrin and metallopeptidase domain (ADAM)17 to assist viral entry into host cells. Clinically, SARS-CoV-2 infection may result in acute lung injury and lung fibrosis, but the underlying mechanisms of COVID-19 induced lung fibrosis are not fully understood. Methods: The networks of ACE2 and its interacting molecules were identified using bioinformatic methods. Their gene and protein expressions were measured in human epithelial cells after 24 h SARS-CoV-2 infection, or in existing datasets of lung fibrosis patients. Results: We confirmed the binding of SARS-CoV-2 and ACE2 by bioinformatic analysis. TMPRSS2, ADAM17, tissue inhibitor of metalloproteinase (TIMP)3, angiotensinogen (AGT), transformation growth factor beta (TGFB1), connective tissue growth factor (CTGF), vascular endothelial growth factor (VEGF) A and fibronectin (FN) were interacted with ACE2, and the mRNA and protein of these molecules were expressed in lung epithelial cells. SARS-CoV-2 infection increased ACE2, TGFB1, CTGF and FN1 mRNA that were drivers of lung fibrosis. These changes were also found in lung tissues from lung fibrosis patients. Conclusions: Therefore, SARS-CoV-2 binds with ACE2 and activates fibrosis-related genes and processes to induce lung fibrosis.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis

et al. 2020

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“…A recent system review which includes a total of 13 cohort or cross-sectional studies examined the association between dietary patterns and risk of frailty showed that a diet high in fruit, vegetables and whole grains was associated with reduced risk of frailty [32]. However, the association between grain consumption in different diseases may differ by age groups [33], and different types of grains may play different roles in disease prevention for older people [18]. Therefore, dietary advice on specific type of grain consumption by different age groups, for different diseases, needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in dietary consumption and its association with frailty among middle-aged and older Australians: a 10-year longitudinal survey

Inglis

Parker

2021

BMC Geriatr

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Background Nutritional status has been considered as a key factor in preventing the development of the frailty syndrome. However, sex-specific dietary consumption transition over time and how it impacts of frailty status are unclear. Method We assessed 113,039 adults (aged 50 years and over) from the 45 and Up Study who had completed both baseline (2006–2009) and follow-up (2012–2015) surveys. Dietary consumption was assessed by a short food frequency questionnaire. Frailty was identified by the FRAIL scale. Multinomial regression models were used to examine the association between a long-term dietary consumption and frailty, stratified by sex. Results Of a total of 113,039 participants, females had a higher percentage of pre-frailty and frailty than males (pre-frailty: 35.5% for female and 30.1% for male; frailty: 4.86% for female and 3.56% for male). As age increased, males had significant decreases in overall dietary risk scores, while females had significant increases in overall dietary risk scores. Males and females with a long-term consumption of adequate fruits, high grains or had a variety of foods were related to a low risk of frailty. Females with a long-term consumption of adequate vegetables or high lean meats and poultry were related to a low risk of frailty. Females with an unhealthy diet at both surveys [Relative Risk Ratio (RRR) = 1.32, 95% CI: 1.18; 1.49], and those with unhealthy diet at either surveys (RRR = 1.28, 95% CI: 1.12; 1.47, RRR = 1.19, 95% CI: 1.04; 1.37) had a higher risk of frailty compared to those had a long-term healthy diet. No association were found between overall dietary risk and frailty for males. Conclusion Males and females changed their dietary consumption as they age. These changes affect its association with frailty, particularly for females. Sex-specific dietary advice in prevention of frailty needs to be further developed.

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“…A cohort study of people aged 3075 and over 65 years old showed that those who consume a lot of vegetables, fruits, whole grains, low-fat dairy products, poultry and fish have lower mortality and higher quality of life 16,17 . A similar study conducted among young people (over 45 years old) also found that large amounts of fruits, vegetables, and foods with high protein content are associated with a lower likelihood of memory loss 18 . Another study showed that adhering to thetraditional Mediterranean diet canreduce overall mortality and neoplastic diseases 19,20 .…”

Section: Dietary Patterns Among the Adult And Elderlymentioning

confidence: 77%

Nutrition Interventions for Healthy Ageing in Indonesia

Sutanto

Basrowi²

2021

AMNT

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Background: Including Indonesia, the elderly population worldwide is on the rise. This situation is closely related to the increase in the incidence and prevalence of non-communicable diseases. Eating behavior is related to the risk of non- communicable the risk of NCDs in the elderly. Therefore, nutrition intervention should be carried out from old age.Objectives: The purpose of this study is to review potential nutritional interventions to prepare for a healthy ageing process in an Indonesian context.Discusion: This review uses social cognition theory to emphasize the importance of nutrition education, the development of nutritional products with biologically active compounds, and practical guidelines that influence individual dietary behavior. Nutritional interventions should take into account Indonesia’s existing food-based balanced nutrition diet guidelines and the dietary patterns of adults and the elderly. Indonesia has a large population, ethnic and cultural diversity, which together affect people’s daily consumption of various foods.Conclusions: Customized nutrition education programs and the development of functional foods are appropriate interventions that can be implemented in Indonesia.

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Eating and healthy ageing: a longitudinal study on the association between food consumption, memory loss and its comorbidities

Cited by 13 publications

References 33 publications

SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis

SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis

Sex differences in dietary consumption and its association with frailty among middle-aged and older Australians: a 10-year longitudinal survey

Nutrition Interventions for Healthy Ageing in Indonesia

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