EasySPR: a web simulador for agile modeling surface plasmon resonance based sensors

Abstract

Surface plasmon resonance (SPR) sensor is a technology for analysis of biomolecular interaction, largely applied in biology and pharmaceutical research. The simulation of the surface plasmon optical excitation is an important steps of the development process for sensors based on this phenomenon. The structure, design and configuration of the desired SPR sensor benefits from previously simulated, analyzing the responses generated and check the feasibility of the materials selected for the optical coupling. Here a online web-based SPR sensor's simulator is presented. With visual-oriented interface, enable drag \& drop actions to easily and quickly modeling a variety of sensors arrangement. The embedded materials database for metals, glasses, polymers and custom substance enable flexible configuration for sensors operating in angular and spectral modes. The light propagation through the multilayer of materials is presented in terms of Fresnel coefficients, which are graphically displayed. The so-called SPR morphology parameters can be visualized. Sensor dynamic behavior could be wispy knowledge by the Sensorgram simulation. Simulation scenario's in various configurations, designs and excitation were performed and compare with other simulator. The proposed simulator guarantee comparable results with an agile and intuitive flow of execution.