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Cited by 57 publications
(32 citation statements)
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“…The component of hydroxyapatite (HA) is close to mineralized bones of human tissues. Thus the hydroxyapatite is suitable for orthopedic and dental applications [4,5]. Porous HA scaffold is beneficial to cell adhesion and proliferation [6].…”
Section: Introductionmentioning
confidence: 99%
“…The component of hydroxyapatite (HA) is close to mineralized bones of human tissues. Thus the hydroxyapatite is suitable for orthopedic and dental applications [4,5]. Porous HA scaffold is beneficial to cell adhesion and proliferation [6].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, these bioceramics are biocompatible, bioactive, osteoconductive, and resorbable (25,26,29,30). Moreover, they can offer great interest as drug delivery systems (31)(32)(33)(34), achieving a therapeutic drug concentration directly at the site to be treated, while maintaining a low systemic drug level (35)(36)(37)(38). In order to evaluate the drug-substance release as well as the biocompatibility and the osteoconductivity of such delivery systems, in vivo studies must be carried out.…”
Section: Introductionmentioning
confidence: 99%
“…Unlike beta-tricalcium phosphate, hydroxyapatite (Ca 10 (PO 4 ) 6 (OH)2) a bioceramic with a low resorption rate and greater mechanical resistance, is commonly used in association with beta-tricalcium phosphate, in the proportion of 60/40 to improve osseointegration of the graft substitute (Balcik et al, 2007). The porosity of the biomaterial is essential for its action, requiring pores of 100-200µm, at a density of 60 to 65% for cellular lodging and vascularization of the treated area, confirming the osteoconductive action of hydroxyapatite (Giannoudis et al, 2005).…”
Section: Bioceramicsmentioning
confidence: 99%