Early versus late pre-intensive care unit admission broad spectrum antibiotics for severe sepsis in adults

The GRADE approach, Part 2: Evidence to decision frameworks—outlining decision-making in health

“…Ejemplo 1. Balance entre beneficios y daños: uso de antibióticos en sepsis 9 La sepsis es un trastorno médico grave caracterizado por una respuesta inflamatoria a una infección que puede afectar todo el cuerpo, cuya tasa de mortalidad es muy alta sin tratamiento. La mayoría de los pacientes con sepsis requiere antibióticos y el ingreso en una unidad de cuidados intensivos.…”

The GRADE approach, Part 2: Evidence to decision frameworks—outlining decision-making in health

“…Ejemplo 1. Balance entre beneficios y daños: uso de antibióticos en sepsis 9 La sepsis es un trastorno médico grave caracterizado por una respuesta inflamatoria a una infección que puede afectar todo el cuerpo, cuya tasa de mortalidad es muy alta sin tratamiento. La mayoría de los pacientes con sepsis requiere antibióticos y el ingreso en una unidad de cuidados intensivos.…”

The time paradox of emergency medicine: Another inverted U curve

“…This demonstrates a non‐sensical failure to understand the temporal nature of illness, let alone heterogeneity. It is notable that a Cochrane review of early versus late antibiotics for sepsis concluded that there was not a single high‐quality study on the topic …”

Nucleic Acid Amplification Techniques

“…Patients with advanced community-acquired sepsis (about 30% of sepsis incidences) are in part already empirically treated with broadspectrum antibiotics at emergency units [111]. In most cases, hospital-acquired (nosocomial) early stage sepsis is treated under constant surveillance by culturebased methods, and timely pressure is lower to anticipate a meaningful cultureor NAT-based result on the underlying infective agent.…”

The GRADE approach, Part 2: Evidence to decision frameworks—outlining decision-making in health

“…Ejemplo 1. Balance entre beneficios y daños: uso de antibióticos en sepsis 9 La sepsis es un trastorno médico grave caracterizado por una respuesta inflamatoria a una infección que puede afectar todo el cuerpo, cuya tasa de mortalidad es muy alta sin tratamiento. La mayoría de los pacientes con sepsis requiere antibióticos y el ingreso en una unidad de cuidados intensivos.…”

The time paradox of emergency medicine: Another inverted U curve

“…This demonstrates a non‐sensical failure to understand the temporal nature of illness, let alone heterogeneity. It is notable that a Cochrane review of early versus late antibiotics for sepsis concluded that there was not a single high‐quality study on the topic …”

Nucleic Acid Amplification Techniques

“…Patients with advanced community-acquired sepsis (about 30% of sepsis incidences) are in part already empirically treated with broadspectrum antibiotics at emergency units [111]. In most cases, hospital-acquired (nosocomial) early stage sepsis is treated under constant surveillance by culturebased methods, and timely pressure is lower to anticipate a meaningful cultureor NAT-based result on the underlying infective agent.…”

The GRADE approach, Part 2: Evidence to decision frameworks—outlining decision-making in health

“…Ejemplo 1. Balance entre beneficios y daños: uso de antibióticos en sepsis 9 La sepsis es un trastorno médico grave caracterizado por una respuesta inflamatoria a una infección que puede afectar todo el cuerpo, cuya tasa de mortalidad es muy alta sin tratamiento. La mayoría de los pacientes con sepsis requiere antibióticos y el ingreso en una unidad de cuidados intensivos.…”

The time paradox of emergency medicine: Another inverted U curve

“…This demonstrates a non‐sensical failure to understand the temporal nature of illness, let alone heterogeneity. It is notable that a Cochrane review of early versus late antibiotics for sepsis concluded that there was not a single high‐quality study on the topic …”

Nucleic Acid Amplification Techniques

“…Patients with advanced community-acquired sepsis (about 30% of sepsis incidences) are in part already empirically treated with broadspectrum antibiotics at emergency units [111]. In most cases, hospital-acquired (nosocomial) early stage sepsis is treated under constant surveillance by culturebased methods, and timely pressure is lower to anticipate a meaningful cultureor NAT-based result on the underlying infective agent.…”