Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants

The Role of Erythropoietin in Preventing Anemia in the Premature Neonate

“…Although univariate regression analysis showed only a near-significant association between rhEPO administration and AOP (p = 0.061), multivariate logistic regression analysis revealed a significant relationship between rhEPO therapy and moderate AOP (OR: 0.36, 95% CI, 0.15-0.89), the most common AOP stage found in this study. This near three-fold reduction in moderate AOP incidence is consistent with a large majority of studies that recommend rhEPO administration and point out multiple benefits of this treatment [1,[9][10][11][12][13][14][15][16]18,19]. Furthermore, this warrants future investigation into the effects rhEPO has on different levels of AOP.…”

The Role of Erythropoietin in Preventing Anemia in the Premature Neonate

“…Although univariate regression analysis showed only a near-significant association between rhEPO administration and AOP (p = 0.061), multivariate logistic regression analysis revealed a significant relationship between rhEPO therapy and moderate AOP (OR: 0.36, 95% CI, 0.15-0.89), the most common AOP stage found in this study. This near three-fold reduction in moderate AOP incidence is consistent with a large majority of studies that recommend rhEPO administration and point out multiple benefits of this treatment [1,[9][10][11][12][13][14][15][16]18,19]. Furthermore, this warrants future investigation into the effects rhEPO has on different levels of AOP.…”

EBNEO Commentary: Cord Blood Red Cell Transfusions and Severe Retinopathy of Prematurity in Preterm Neonates

“…Additionally, logistical and cost barriers-cord collection, processing, and inventory constraints-would currently prevent large-scale adoption [2]. This trial aligns with previous observational data linking lower HbF levels to higher ROP and BPD risk [3,4]. It adds randomised evidence supporting a potential causal mechanism but falls short of establishing clinical efficacy.…”

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

“…Of 16 025 titles and abstracts screened, 876 full-text articles were assessed, and 154 systematic reviews evaluating 251 different research questions were included in the final umbrella review (eFigure 1 in the Supplement). The characteristics of the included systematic reviews are shown in eTable 2 in the Supplement.…”

The Role of Erythropoietin in Preventing Anemia in the Premature Neonate

“…Although univariate regression analysis showed only a near-significant association between rhEPO administration and AOP (p = 0.061), multivariate logistic regression analysis revealed a significant relationship between rhEPO therapy and moderate AOP (OR: 0.36, 95% CI, 0.15-0.89), the most common AOP stage found in this study. This near three-fold reduction in moderate AOP incidence is consistent with a large majority of studies that recommend rhEPO administration and point out multiple benefits of this treatment [1,[9][10][11][12][13][14][15][16]18,19]. Furthermore, this warrants future investigation into the effects rhEPO has on different levels of AOP.…”

EBNEO Commentary: Cord Blood Red Cell Transfusions and Severe Retinopathy of Prematurity in Preterm Neonates

“…Additionally, logistical and cost barriers-cord collection, processing, and inventory constraints-would currently prevent large-scale adoption [2]. This trial aligns with previous observational data linking lower HbF levels to higher ROP and BPD risk [3,4]. It adds randomised evidence supporting a potential causal mechanism but falls short of establishing clinical efficacy.…”

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

“…Of 16 025 titles and abstracts screened, 876 full-text articles were assessed, and 154 systematic reviews evaluating 251 different research questions were included in the final umbrella review (eFigure 1 in the Supplement). The characteristics of the included systematic reviews are shown in eTable 2 in the Supplement.…”

The Role of Erythropoietin in Preventing Anemia in the Premature Neonate

“…Although univariate regression analysis showed only a near-significant association between rhEPO administration and AOP (p = 0.061), multivariate logistic regression analysis revealed a significant relationship between rhEPO therapy and moderate AOP (OR: 0.36, 95% CI, 0.15-0.89), the most common AOP stage found in this study. This near three-fold reduction in moderate AOP incidence is consistent with a large majority of studies that recommend rhEPO administration and point out multiple benefits of this treatment [1,[9][10][11][12][13][14][15][16]18,19]. Furthermore, this warrants future investigation into the effects rhEPO has on different levels of AOP.…”

EBNEO Commentary: Cord Blood Red Cell Transfusions and Severe Retinopathy of Prematurity in Preterm Neonates

“…Additionally, logistical and cost barriers-cord collection, processing, and inventory constraints-would currently prevent large-scale adoption [2]. This trial aligns with previous observational data linking lower HbF levels to higher ROP and BPD risk [3,4]. It adds randomised evidence supporting a potential causal mechanism but falls short of establishing clinical efficacy.…”

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

“…Of 16 025 titles and abstracts screened, 876 full-text articles were assessed, and 154 systematic reviews evaluating 251 different research questions were included in the final umbrella review (eFigure 1 in the Supplement). The characteristics of the included systematic reviews are shown in eTable 2 in the Supplement.…”