Early Treatment of a Single Generalized Tonic-Clonic Seizure to Prevent Recurrence

Abstract

Treatment after a single unprovoked seizure leads to a significant reduction in the risk of relapse of generalized tonic-clonic epilepsy.

Treatment response and predictors in patients with newly diagnosed epilepsy in Ethiopia: a retrospective cohort study

“…We demonstrated that patients with a high number of pre-treatment seizures were associated with poor treatment seizure remission. In line with current findings, previous studies have shown that a higher number of seizures prior to treatment was associated with lower chances of remission 30–35 . The role of the number of seizures prior to treatment is based on the theory that prolonged and recurrent seizures may contribute to neuronal damage and the development of new epileptic foci 36 .…”

Treatment response and predictors in patients with newly diagnosed epilepsy in Ethiopia: a retrospective cohort study

“…We demonstrated that patients with a high number of pre-treatment seizures were associated with poor treatment seizure remission. In line with current findings, previous studies have shown that a higher number of seizures prior to treatment was associated with lower chances of remission 30–35 . The role of the number of seizures prior to treatment is based on the theory that prolonged and recurrent seizures may contribute to neuronal damage and the development of new epileptic foci 36 .…”

Treatment response and its predictors among epilepsy patients: a retrospective cohort study

“…We demonstrated that patients with a high frequency of pre-treatment seizure were associated with poor treatment seizure remission (AHR 0.716, 95% CI 0.558, 0.919). In accordance with the present results, previous studies have demonstrated that a higher pre-treatment seizure frequency has been repeatedly associated with a lower chance of remission [19][20][21][22][23][24]. The role of the number of pre-treatment seizure was based on the theory that prolonged and recurrent seizure caused neuronal damage and the development of new epileptic foci [25].…”

Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG

“…In another study, 87 adult patients with a first unprovoked GTC seizure were randomized to immediate or delayed treatment. 8 After 36 months of follow-up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence. In that study, however, no significant correlation was found between the presence of epileptic discharges and the rate of recurrence.…”

“…The authors, however, did not separately evaluate the recurrence rates of patients with focal spikes and those with GSWDs on their EEG studies. In another study, 87 adult patients with a first unprovoked GTC seizure were randomized to immediate or delayed treatment 8 . After 36 months of follow‐up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence.…”

“…After 36 months of follow‐up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence. In that study, however, no significant correlation was found between the presence of epileptic discharges and the rate of recurrence 8 . One study that evaluated 147 adults with an unprovoked GTC seizure reported surprising results, since no statistically significant differences in recurrence rates between treated and untreated patients were found 15 .…”

Treatment response and predictors in patients with newly diagnosed epilepsy in Ethiopia: a retrospective cohort study

“…We demonstrated that patients with a high number of pre-treatment seizures were associated with poor treatment seizure remission. In line with current findings, previous studies have shown that a higher number of seizures prior to treatment was associated with lower chances of remission 30–35 . The role of the number of seizures prior to treatment is based on the theory that prolonged and recurrent seizures may contribute to neuronal damage and the development of new epileptic foci 36 .…”

Treatment response and its predictors among epilepsy patients: a retrospective cohort study

“…We demonstrated that patients with a high frequency of pre-treatment seizure were associated with poor treatment seizure remission (AHR 0.716, 95% CI 0.558, 0.919). In accordance with the present results, previous studies have demonstrated that a higher pre-treatment seizure frequency has been repeatedly associated with a lower chance of remission [19][20][21][22][23][24]. The role of the number of pre-treatment seizure was based on the theory that prolonged and recurrent seizure caused neuronal damage and the development of new epileptic foci [25].…”

Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG

“…In another study, 87 adult patients with a first unprovoked GTC seizure were randomized to immediate or delayed treatment. 8 After 36 months of follow-up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence. In that study, however, no significant correlation was found between the presence of epileptic discharges and the rate of recurrence.…”

“…The authors, however, did not separately evaluate the recurrence rates of patients with focal spikes and those with GSWDs on their EEG studies. In another study, 87 adult patients with a first unprovoked GTC seizure were randomized to immediate or delayed treatment 8 . After 36 months of follow‐up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence.…”

“…After 36 months of follow‐up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence. In that study, however, no significant correlation was found between the presence of epileptic discharges and the rate of recurrence 8 . One study that evaluated 147 adults with an unprovoked GTC seizure reported surprising results, since no statistically significant differences in recurrence rates between treated and untreated patients were found 15 .…”

Treatment response and predictors in patients with newly diagnosed epilepsy in Ethiopia: a retrospective cohort study

“…We demonstrated that patients with a high number of pre-treatment seizures were associated with poor treatment seizure remission. In line with current findings, previous studies have shown that a higher number of seizures prior to treatment was associated with lower chances of remission 30–35 . The role of the number of seizures prior to treatment is based on the theory that prolonged and recurrent seizures may contribute to neuronal damage and the development of new epileptic foci 36 .…”

Treatment response and its predictors among epilepsy patients: a retrospective cohort study

“…We demonstrated that patients with a high frequency of pre-treatment seizure were associated with poor treatment seizure remission (AHR 0.716, 95% CI 0.558, 0.919). In accordance with the present results, previous studies have demonstrated that a higher pre-treatment seizure frequency has been repeatedly associated with a lower chance of remission [19][20][21][22][23][24]. The role of the number of pre-treatment seizure was based on the theory that prolonged and recurrent seizure caused neuronal damage and the development of new epileptic foci [25].…”

Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG

“…In another study, 87 adult patients with a first unprovoked GTC seizure were randomized to immediate or delayed treatment. 8 After 36 months of follow-up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence. In that study, however, no significant correlation was found between the presence of epileptic discharges and the rate of recurrence.…”

“…The authors, however, did not separately evaluate the recurrence rates of patients with focal spikes and those with GSWDs on their EEG studies. In another study, 87 adult patients with a first unprovoked GTC seizure were randomized to immediate or delayed treatment 8 . After 36 months of follow‐up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence.…”

“…After 36 months of follow‐up, the recurrence rate was significantly higher among the untreated group (71%) compared to the treated group (22%), results very comparable to ours at 3 years with 69% and 15% of untreated and treated patients, respectively, experiencing a recurrence. In that study, however, no significant correlation was found between the presence of epileptic discharges and the rate of recurrence 8 . One study that evaluated 147 adults with an unprovoked GTC seizure reported surprising results, since no statistically significant differences in recurrence rates between treated and untreated patients were found 15 .…”