Early tissue incorporation and collagen deposition in lightweight polypropylene meshes: bioassay in an experimental model of ventral hernia

Pascual, Gemma; Rodrı́guez, Marta; Gómez-Gil, Verónica; García‐Honduvilla, Natalio; Buján, Julia; Bellón, Juan M.

doi:10.1016/j.surg.2008.04.005

Cited by 62 publications

(25 citation statements)

References 20 publications

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“…In an animal study using the abdominal wall, Pascual et al investigated the influence of pore size and mesh weight on collagen production and its subsequent impact on tensile strength [14]. Four different PP meshes were used: At 14 days, lighter-weight meshes with larger pore size induced more collagen type III deposition and faster conversion to type I than heavy-weight meshes.…”

Section: Quality Of Scar Formationmentioning

confidence: 99%

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Polypropylene mesh and the host response

2012

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Section: Quality Of Scar Formationmentioning

confidence: 99%

“…This is characterized by macrophage activation and fibroblast proliferation, the activity of which is mediated by cytokines and growth factors [14]. The response also varies depending on the particular surface characteristics.…”

Section: Host Response At a Cellular Levelmentioning

confidence: 99%

Polypropylene mesh and the host response

2012

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“…The vast majority of existing experimental IH models have focused on creating regular fascia defects and subsequently applying treatment modalities such as meshes or biologic growth factors [11,12,13,14,15,16,17]. Therefore, these existing models are less suitable for investigating the changes in the early fascia healing after abdominal incisions that potentially may lead to IH formation.…”

Section: Introductionmentioning

confidence: 99%

An Experimental Animal Model for Abdominal Fascia Healing after Surgery

Burcharth

Pommergaard²,

Klein³

et al. 2013

Eur Surg Res

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Background: Incisional hernia (IH) is a well-known complication after abdominal surgical procedures. The exact etiology of IH is still unknown even though many risk factors have been suggested. The aim of this study was to create an animal model of a weakly healed abdominal fascia that could be used to evaluate the actively healing fascia. Such an animal model may promote future research in the prevention of IH. Methods: 86 male Sprague-Dawley rats were used to establish a model involving six experiments (experiments A-F). Mechanical testing of the breaking strength of the healed fascia was performed by testing tissue strips from the healed fascia versus the unincised control fascia 7 and 28 days postoperatively. Results: During the six experiments a healing model was created that produced significantly weaker coherent fascia when compared with the control tissue measured in terms of mechanical breaking strength. This new animal model employed myofascial closing after a full thickness abdominal incision using a running suture with fast-absorbable suture material. This technique produced a weak myofascial layer compared with the control tissue measured in terms of breaking strength after both 7 and 28 days. Conclusion: It was possible to create a healed but weak abdominal fascia in rats with a minimum of defects after incision using a running suture technique in the fascia. In contrast to other models, regular tissue defects were absent, and the model can therefore be used to evaluate the changes, both histological and mechanical, in the actively healing fascia, which may lead to incisional herniation. Furthermore, the model may also be used to study interventions performed to promote healing. This contrasts with existing models with regular fascia defects, which are not well suited for this purpose.

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“…However, the numerous large-pore and lightweight meshes, which mainly consist of polypropylene filaments, differ in their basic structure. These different textile structures with different pore sizes and different polymers lead to various tissue reactions to the implant at cellular and extracellular levels [27,28]. It is important to realize that the weights of both meshes are not comparable because structure and weight of PTFE and polypropylene filaments are different.…”

Section: Introductionmentioning

confidence: 99%

“…Not only is the weight of the implanted mesh of vital importance but also its structure and pore size [28,29]. Data recently published reported a distinctive tendency of shrinking of between 4 and 51% for PTFE meshes with small pores in experimental animal studies [30].…”

Section: Introductionmentioning

confidence: 99%