Early Stage olfactory neuroblastoma and the impact of resecting dura and olfactory bulb

Mays, Ashley C.; Bell, Diana; Ferrarotto, Renata; Phan, Jack; Roberts, Dianna B.; Fuller, Clifton D.; Frank, Steven J.; Raza, Shaan M.; Kupferman, Michael E.; DeMonte, Franco; Hanna, Ehab Y.; Su, Shirley Y.

doi:10.1002/lary.26908

Cited by 16 publications

(11 citation statements)

References 31 publications

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“…For early stage disease confined to the sinonasal cavity, single modality treatment with surgery yields a high degree of oncological control. 20 However, for advanced disease, multimodality approach is preferred. Due to high local failure rate, surgical resection followed by PORT is adapted by many institutions.…”

Section: Discussionmentioning

confidence: 99%

“…The optimal treatment approach for ONB is not uniform due to the few number of published cases and absence of prospective studies. For early stage disease confined to the sinonasal cavity, single modality treatment with surgery yields a high degree of oncological control 20 . However, for advanced disease, multimodality approach is preferred.…”

Section: Discussionmentioning

confidence: 99%

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Long‐Term Outcomes of Olfactory Neuroblastoma: MD Anderson Cancer Center Experience and Review of the Literature

et al. 2021

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Objectives/Hypothesis: Olfactory neuroblastoma (ONB) is a rare sinonasal malignant neoplasm that is known to develop late recurrence. The aim of this study is to evaluate the long-term outcomes of patients with ONB and to determine the factors associated with prognosis.Study Design: Retrospective study. Methods: A retrospective review of the medical records of 139 patients diagnosed with ONB at MD Anderson Cancer Center was performed between 1991 and 2016. Descriptive statistics were calculated, and Kaplan-Meier curves were utilized to assess survival.Results: Median follow-up time was 75 months. Overall, 129 patients (92.8%) had surgery as part of their treatment and 82 (58.9%) patients received postoperative radiation therapy (PORT) or concurrent chemoradiotherapy. Endoscopic approaches were utilized for 72 patients, 69.4% of whom had pure endoscopic endonasal approaches. Five-year overall survival and disease-specific survival were 85.6% and 93.4%, respectively. Recurrence rate was 39.6% with a median time to recurrence of 42 months. Among the 31 patients who received elective nodal irradiation (ENI), two patients developed neck recurrence (6.4%) compared with 20 who developed neck recurrence when ENI was omitted (34.4%) (P = .003). Advanced Kadish stage, orbital invasion, intracranial invasion, and presence of cervical lymphadenopathy at the time of presentation were significantly associated with poor survival.Conclusion: ONB has an excellent survival. Surgical resection with PORT when indicated is the mainstay of treatment. Endoscopic approaches can be used as a good tool. Elective neck irradiation reduces the risk of nodal recurrence among patients with clinically N0 neck. Despite the excellent survival, recurrence rate remains high and delayed, highlighting the need for long-term surveillance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long‐Term Outcomes of Olfactory Neuroblastoma: MD Anderson Cancer Center Experience and Review of the Literature

et al. 2021

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“…The present series counted a total of 112 cases of ONB, with 10-year OS and DFS of 90.9% and 69.1%, respectively, comparing equal or better with other series [30][31][32]. According to the literature, most recognized negative prognostic factors for ONB are advanced Kadish stage, high Hyams grade, the presence of nodal metastasis and infiltrated postoperative surgical margins [30,31,[33][34][35][36].…”

Section: Olfactory Neuroblastoma (Onb)mentioning

confidence: 50%

Patterns of recurrences in sinonasal cancers undergoing an endoscopic surgery-based treatment: Results of the MUSES* on 940 patients

Arosio¹,

Bernasconi²,

Valsecchi³

et al. 2022

Oral Oncology

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“…Meerwein CM et al [12] claimed that surgery alone is an equivalent alternative to combined treatment in early-stage ONB patients. Mays AC et al [13] reported that PORT did not impact disease-free survival in early-stage ONB. An NCDB study by Carey RM et al [14] used patients with stage A and B as a combined stage for survival analysis, and the results showed that surgery alone, compared with PORT, had no signi cant difference in survival.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical resection followed by postoperative radiotherapy (PORT) is considered the primary option for ONB patients [3]. However, controversy exists regarding whether early-stage ONB patients can bene t from PORT to improve their survival [2,[10][11][12][13][14]. Moreover, previous studies demonstrated that PORT was not effective in improving long-term survival [15].…”

Section: Introductionmentioning

confidence: 99%

Survival Impact of Postoperative Radiotherapy in Patients with Olfactory Neuroblastoma ： 513 Cases from the SEER Database

Duo

Feng

Zhang

et al. 2021

Preprint

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BackgroundTo evaluate the impact of postoperative radiotherapy (PORT) on survival in olfactory neuroblastoma (ONB) patients with different stages. MethodsPatients with ONB were selected in the Surveillance, Epidemiology, and End Results (SEER) database during 2004–2016. Survival analyses were performed using Kaplan Meier (K-M) method, Cox regression analysis, and competing risk model. ResultsA total of 513 patients were included in the study. Univariate and multivariate analysis results demonstrated that PORT was not an independent prognostic factor for overall survival (OS) of patients with modified Kadish stage A and B (p=0.699 and p=0.248, respectively). For C and D cases, patients who underwent PORT had significantly better OS than those who did not undergo PORT (p=0.03 and p< 0.0001, respectively). K-M curves illustrated that the 5- and 10-year OS rates according to radiotherapy (PORT vs. non-PORT) were 70.4% vs. 85.3% and 56.8% vs. 68.2% in stage C, respectively. For stage D patients, the 5-year OS rates were 42.6% and 70.7%, and 10-year OS rates were 29.5% and 53.4% in the PORT and non-PORT groups, respectively. The competitive risk model revealed that the 5-year cancer-specific cumulative mortality incidence decreased by 26.6% and the 10-year mortality incidence by 41.4% in patients with stage C who were treated using PORT; meanwhile, for patients with stage D who were treated with PORT, the 5- and 10-year mortality incidence reduced by 35.3% and 42.6%, respectively. Chemotherapy was not related to the prognosis of ONB (all p> 0.05).ConclusionsOur results indicate that PORT improved survival outcomes in ONB patients with modified Kadish stage C and D. However, for modified Kadish stage A and B cases, PORT may not affect survival. Chemotherapy was not recommended for ONB patients until more studies determine the role of chemotherapy.

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Early Stage olfactory neuroblastoma and the impact of resecting dura and olfactory bulb

Abstract: 4. Laryngoscope, 128:1274-1280, 2018.

Cited by 16 publications

References 31 publications

Long‐Term Outcomes of Olfactory Neuroblastoma: MD Anderson Cancer Center Experience and Review of the Literature

Long‐Term Outcomes of Olfactory Neuroblastoma: MD Anderson Cancer Center Experience and Review of the Literature

Patterns of recurrences in sinonasal cancers undergoing an endoscopic surgery-based treatment: Results of the MUSES* on 940 patients

Survival Impact of Postoperative Radiotherapy in Patients with Olfactory Neuroblastoma ： 513 Cases from the SEER Database

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