Early stage carcinoma of oral tongue: prognostic factors for local control and survival

Al-Rajhi, Nasser; Khafaga, Yasser; El-Husseiny, Gamal; Saleem, Mohammad; Mourad, Walid A.; Al-Otieschan, Abdullah T.; Al-Amro, Abdullah S.

doi:10.1016/s1368-8375(00)00042-7

Cited by 157 publications

(123 citation statements)

References 21 publications

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“…The risk of nodal metastases and mortality rates vary directly with the thickness of the primary tumor. 8,11,26 O-charoenrat et al found that tumor thickness above 5 mm is a strong predictor of occult nodal metastases and should indicate an elective neck dissection. 8 There is evidence that tumor thickness may exercise more influence on the survival rates than factors such as clinical and pathologic staging.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…Most authors have established significant correlations between lower histologic differentiation and poorer prognosis, 7,9,20,27,37 but others did not find such association. 8,10,11 Perineural invasion. Perineural invasion apparently correlates with higher probability of regional and distant metastases, higher depth of tumor invasion, lower differentiation, and lower 5-year survival rates in OSCC.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…A strong correlation has been demonstrated between a resection margin free of disease and higher survival rates, with longer time until recurrence of disease. 11,31,35 …”

Section: Treatment-related Factorsmentioning

confidence: 99%

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Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

542

436

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Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

542

436

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“…When these residual cells are not eradicated by adjuvant treatments, they give rise to recurrences. The volume of residual cancer following surgery negatively impacts overall survival (4,(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy

et al. 2017

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Effectiveness of surgery as a cancer treatment is reduced when all cancer cells are not detected during surgery, leading to recurrences that negatively impact survival. To maximize cancer cell detection during cancer surgery, we designed an in situ intraoperative, label-free, optical cancer detection system that combines intrinsic fluorescence spectroscopy, diffuse reflectance spectroscopy, and Raman spectroscopy. Using this multimodal optical cancer detection system, we found that brain, lung, colon, and skin cancers could be detected in situ during surgery with an accuracy, sensitivity, and specificity of 97%, 100%, and 93%, respectively. This highly sensitive optical molecular imaging approach can profoundly impact a wide range of surgical and noninvasive interventional oncology procedures by improving cancer detection capabilities, thereby reducing cancer burden and improving survival and quality of life.

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“…We also confirmed previous reports indicating the prognostic value of tumor size 11,23,24 and the lack of an association between survival and tumor grade. 12,[25][26][27] The literature regarding histologic features and prognosis of tongue cancer is rather voluminous and goes back at least 20 years; however, it is important to point out several differences between our report and other studies published to date. To our knowledge, all previous studies were based on data from single institutions, whereas our analyses were population-based.…”

Section: Discussionmentioning

confidence: 64%

Invasion characteristics of oral tongue cancer

Goodman¹,

Liu²,

Ward³

et al. 2009

Cancer

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Background This study explored the blood transfusion patterns, SCD complications, utilization of iron chelation therapies (ICT), healthcare resource use, and costs in pediatric, transitioning (18 years old) and adult patients with SCD. Procedure Data from Florida (1998–2009), New Jersey (1996–2009), Missouri (1997–2010), Kansas (2001–2009), and Iowa (1998–2010) state Medicaid were used. Patients with ≥2 SCD diagnoses and ≥1 transfusion event were included. Rates of transfusion events, SCD complications, and proportion of eligible patients receiving ICT were calculated. ICT eligibility was defined as receiving ≥10 transfusions over lifetime. SCD complications included pain, pulmonary event, infection event, renal, cardiovascular, stroke, leg ulcers, and avascular necrosis. Regressions were used to assess risk factors for transfusion and identify the main drivers of costs. Results The sample included 3,208 patients. The transfusion rate increased from 1‐year‐old to a peak at 16 years old, then dropped until age 26 and remained stable thereafter. In contrast the frequency of diagnoses for SCD complications increased markedly after age 16. Post‐transition patients (≥18 years old) were significantly associated with fewer transfusions (odds ratio: 0.80, P = 0.002). Among eligible patients for ICT, there was no statistically significant difference in total cost between the ICT and no ICT groups (adjusted cost difference, $136, P = 0.114). Conclusions Patients transitioning to adult care received less transfusions and hydroxyurea, less ICT when eligible for chelation therapy, had higher healthcare costs and suffered from more frequent SCD related complications than pediatric patients. These findings highlight the changes in treatment patterns corresponding to transition to adult care. Pediatr Blood Cancer 2013; 60: 828–835. © 2013 Wiley Periodicals, Inc.

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Early stage carcinoma of oral tongue: prognostic factors for local control and survival

Cited by 157 publications

References 21 publications

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy

Invasion characteristics of oral tongue cancer

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