2022
DOI: 10.3390/brainsci12010093
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Background: Altered sensorimotor gating has been demonstrated by Prepulse Inhibition (PPI) tests in patients with psychosis. Recent advances in signal processing methods allow assessment of neural PPI through electroencephalogram (EEG) recording during acoustic startle response measures (classic muscular PPI). Simultaneous measurements of muscular (eye-blink) and neural gating phenomena during PPI test may help to better understand sensorial processing dysfunctions in psychosis. In this study, we aimed to asse… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
4
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(4 citation statements)
references
References 118 publications
(145 reference statements)
0
4
0
Order By: Relevance
“…However, studies that evaluated subjects with major depressive disorder were less consistent, since two studies did not report differences in PPI magnitude for patients with depression but without psychotic symptomatology [73,79]. Similarly, those studies that reported reduced PPI included bipolar patients with psychotic symptoms [69,104]. These ndings support the idea that PPI could be modulated by active symptomatology [59].…”
Section: Discussionmentioning
confidence: 94%
See 1 more Smart Citation
“…However, studies that evaluated subjects with major depressive disorder were less consistent, since two studies did not report differences in PPI magnitude for patients with depression but without psychotic symptomatology [73,79]. Similarly, those studies that reported reduced PPI included bipolar patients with psychotic symptoms [69,104]. These ndings support the idea that PPI could be modulated by active symptomatology [59].…”
Section: Discussionmentioning
confidence: 94%
“…studies (56.25%) revealed reduced PPI in patients compared to the control group. Speci cally, 7 of 12 studies with bipolar disorder patients informed of a PPI de cit[69, 82, 84,92,[100][101]104]. Only one study reported reduced PPI in women from the control group compared to bipolar patients[84].…”
mentioning
confidence: 99%
“…The sensorimotor gating is also an information processing measurement, and PPI deficits have been repeatedly reported in patients with schizophrenia (Braff et al, 2001; Hedberg et al, 2021; San-Martin et al, 2022). Although some studies show PPI deficits using 30 ms of interstimulus interval (Minassian et al, 2007), our results are similar to Meincke et al (2004) and San-Martin et al (2022), where they observed alterations in schizophrenia patients when the PPI were presented with 100 ms or 120 ms interstimulus, but not in the trials using an ISI of 30 ms (Figure 8E-F). This suggests that Slc10a4 -/- animals present increased processing to long-latency repetitive stimulus, which was also observed by the increased second click P80 component, indicating alteration in attenuation of repetitive sensory information.…”
Section: Discussionmentioning
confidence: 99%
“…The individual characteristics of sensory and sensorimotor gating are assumed to contribute to higher cognitive functions (working memory, voluntary attention and executive functions), which are deficient under psychopathological conditions (Bitsios and Giakoumaki, 2005 ; Holstein et al, 2011 ; Toyomaki et al, 2015 ). P50 suppression and PPI are impaired in patients with schizophrenia (Braff et al, 2001 ; Swerdlow et al, 2008 ; Braff, 2010 ; San-Martin et al, 2020 , 2022 ). The measures display a significant degree of heritability (Clementz et al, 1998 ; Cadenhead et al, 2005 ; Hasenkamp et al, 2010 ; Earls et al, 2016 ; Togay et al, 2020 ; Li et al, 2021 ) and are considered to be sendo phenotypes of schizophrenia (Turetsky et al, 2007 ; DiLalla et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%