Early revision events among patients with a three dimensional (3D) printed cellular titanium or PEEK (polyetheretherketone) spinal cage for single-level lumbar spinal fusion

Corso, K.; Kothari, Prerna; Corrado, Kristin; Michielli, Annalisa; Ruppenkamp, J.; Bowden, Dawn E.

doi:10.1080/17434440.2022.2020637

Cited by 6 publications

(13 citation statements)

References 23 publications

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“…Excluding the nonclinical studies, there was a total population of 299 human and 59 ovine subjects, with 134 human (44.8%) and 38 ovine models (64.4%) implanted with 3D-pTi cages. Six studies reported results favoring 3D-pTi, while 1 study [ 19 ] reported equivocal outcomes for 3D-pTi and PEEK devices ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Corso et al [ 19 ] included 186 patients (50.5% male) with a mean age of 59.2± 12.5 years and a minimum follow-up of 6 months. Of the 186 patients, 96 received 3D-pTi implants and 90 received PEEK; 186 total levels were implanted with 96 (51.6%) of those consisting of 3D-pTi implants.…”

Section: Resultsmentioning

confidence: 99%

“…The most common surgical indications for 3D-pTi cage implantation included spondylolistheses, spinal stenosis, foraminal stenosis, and degenerative disc disease ( Table 3 ). To control for the confounding effects of demographic variables, Corso et al [ 19 ] also propensity-matched patients, finding that, among matched patients, nonerequired device-related revisions. From these results, Corso et al [ 19 ] conclude that for nondevice-related reoperation events, 3D-pTi cages are associated with minimal risk when compared to non-3D printed cages.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, with respect to clinical outcomes, Corso et al [ 19 ] reported no occurrence of 3D-pTi device-related revision surgeries within 6 months of the initial fusion procedure. For comparison, the randomized controlled trial conducted by Kersten et al [ 36 ] showed an additional procedure rate of 2.1% within 6 months of PEEK interbody device implantation in transforaminal LIF (TLIF) procedures.…”

Section: Discussionmentioning

confidence: 99%

“…On multivariate analysis, Adl Amini et al [ 18 ] found only 2 other demographic or surgical factors that were a significant predictor of subsidence: diagnosis of degenerative disk disease and volumetric bone density. Corso et al [ 19 ] performed a propensity-matched study, eliminating the potential for confounding demographic variables to influence the final outcomes. However, as a result of cohort matching, they were unable to elucidate relationships between patient demographics, surgery-related factors and functional outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Three-Dimensional-Printed Titanium Versus Polyetheretherketone Cages for Lumbar Interbody Fusion: A Systematic Review of Comparative In Vitro, Animal, and Human Studies

Patel,

O’Bryant,

Rogers

et al. 2023

Neurospine

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Interbody fusion is a workhorse technique in lumbar spine surgery that facilities indirect decompression, sagittal plane realignment, and successful bony fusion. The 2 most commonly employed cage materials are titanium (Ti) alloy and polyetheretherketone (PEEK). While Ti alloy implants have superior osteoinductive properties they more poorly match the biomechanical properties of cancellous bones. Newly developed 3-dimensional (3D)-printed porous titanium (3D-pTi) address this disadvantage and are proposed as a new standard for lumbar interbody fusion (LIF) devices. In the present study, the literature directly comparing 3D-pTi and PEEK interbody devices is systematically reviewed with a focus on fusion outcomes and subsidence rates reported in the <i>in vitro</i>, animal, and human literature. A systematic review directly comparing outcomes of PEEK and 3D-pTi interbody spinal cages was performed. PubMed, Embase, and Cochrane Library databases were searched according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Mean Newcastle-Ottawa Scale score for cohort studies was 6.4. A total of 7 eligible studies were included, comprising a combination of clinical series, ovine animal data, and <i>in vitro</i> biomechanical studies. There was a total population of 299 human and 59 ovine subjects, with 134 human (44.8%) and 38 (64.4%) ovine models implanted with 3D-pTi cages. Of the 7 studies, 6 reported overall outcomes in favor of 3D-pTi compared to PEEK, including subsidence and osseointegration, while 1 study reported neutral outcomes for device related revision and reoperation rate. Though limited data are available, the current literature supports 3D-pTi interbodies as offering superior fusion outcomes relative to PEEK interbodies for LIF without increasing subsidence or reoperation risk. Histologic evidence suggests 3D-Ti to have superior osteoinductive properties that may underlie these superior outcomes, but additional clinical investigation is merited.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%