Early rescue administration of surfactant and nasal continuous positive airway pressure in preterm infants <32 weeks gestation

Abstract

Implementation of prophylactic or early rescue administration of surfactant with NCPAP in infants at high risk for developing RDS in neonatal ICU is a safe modality of respiratory support in preterm infants.

Predictors of mortality in premature babies with respiratory distress syndrome treated by early rescue surfactant therapy

“…Comparison of morbidity profiles revealed higher rates of sepsis (31.8%) in the present study, which was lower than the previous Indian reports, comparable to Korean experience but more than double of a study from a Greece [16–19]. The patients in present study are from low socioeconomic status, although, majority of pregnant mothers (91.8%) were booked prior to the delivery but most of them usually have imminent delivery due to poor educational as well as socioeconomic status, and hence, the rate of use of intrapartum antibiotics was also less, in addition inappropriate nurse: patient ratio and overcrowding also contributed to high sepsis rate.…”

“…Among babies receiving early rescue SRT, survival was 65.45%. Although our gestational age specific survival rates after SRT is comparable to previous studies from India, however, it is lower than that reported from the developed countries [16][17][18]. In a longitudinal study from Korea, mortality was 14.3% for a period of 2007.…”

“…Among babies receiving early rescue SRT, survival was 65.45%. Although our gestational age specific survival rates after SRT is comparable to previous studies from India, however, it is lower than that reported from the developed countries [16–18]. In a longitudinal study from Korea, mortality was 14.3% for a period of 2007.19 High mortality rate seen in our study can be attributed to lack of adequate number of healthcare staff and overcrowding as our centre is the largest referral hospital in northern India.…”

Predictors of mortality in premature babies with respiratory distress syndrome treated by early rescue surfactant therapy

“…Comparison of morbidity profiles revealed higher rates of sepsis (31.8%) in the present study, which was lower than the previous Indian reports, comparable to Korean experience but more than double of a study from a Greece [16–19]. The patients in present study are from low socioeconomic status, although, majority of pregnant mothers (91.8%) were booked prior to the delivery but most of them usually have imminent delivery due to poor educational as well as socioeconomic status, and hence, the rate of use of intrapartum antibiotics was also less, in addition inappropriate nurse: patient ratio and overcrowding also contributed to high sepsis rate.…”

“…Among babies receiving early rescue SRT, survival was 65.45%. Although our gestational age specific survival rates after SRT is comparable to previous studies from India, however, it is lower than that reported from the developed countries [16][17][18]. In a longitudinal study from Korea, mortality was 14.3% for a period of 2007.…”

“…Among babies receiving early rescue SRT, survival was 65.45%. Although our gestational age specific survival rates after SRT is comparable to previous studies from India, however, it is lower than that reported from the developed countries [16–18]. In a longitudinal study from Korea, mortality was 14.3% for a period of 2007.19 High mortality rate seen in our study can be attributed to lack of adequate number of healthcare staff and overcrowding as our centre is the largest referral hospital in northern India.…”

Estrategias de oxigenoterapia y soporte ventilatorio, en cuidado intensivo neonatal post administración de surfactante pulmonar

“…De acuerdo, con lo publicado por varios autores, estos métodos menos invasivos pueden disminuir la necesidad de soporte ventilatorio y la incidencia de Displasia Broncopulmonar, en el manejo clásico de intubación para la administración de surfactante y ventilación mecánica invasiva o no invasiva (34)(35)(36) . Algunos estudios han comparado la técnica INSURE con CPAP y Ventilación Mecánica, en algunos estudios se obtuvieron resultados que confirman que un 46% de recién nacidos pretérminos con SDR pueden ser manejados con la técnica INSURE sin tener en cuenta la ventilación mecánica (37) ; en el estudio de Tsakalidis la experiencia con el manejo de la técnica de INSURE en una UCIN de Grecia, reportó que de 81 prematuros menores de 28 y 32 semanas fueron extubados exitosamente y de ellos el 93,83% no requirieron reintubación (38) . Para este estudio, la técnica de Ventilación Nasal con presión Positiva Intermitente fue empleada en recién nacidos con menos de 30,8 semanas, de acuerdo con la utilización de esta estrategia y según la revisión realizada, esta reduce la incidencia de fracaso de la extubación en 48 horas para siete días (39) .…”

Single dose surfactant early rescue therapy in respiratory distress syndrome-experience and outcome at a tertiary care centre

“…Although our gestational age specific mortality after surfactant replacement therapy was comparable to previous Indian reports, it was higher than western reports. 23,24 We face problems of inappropriate nurse: patient ratios and overcrowding. Overall mortality in surfactant recipient neonates was 25.5% which was inversely related to gestational age (25) which is comparable to other studies from developing world (21-80%).…”

Predictors of mortality in premature babies with respiratory distress syndrome treated by early rescue surfactant therapy

“…Comparison of morbidity profiles revealed higher rates of sepsis (31.8%) in the present study, which was lower than the previous Indian reports, comparable to Korean experience but more than double of a study from a Greece [16–19]. The patients in present study are from low socioeconomic status, although, majority of pregnant mothers (91.8%) were booked prior to the delivery but most of them usually have imminent delivery due to poor educational as well as socioeconomic status, and hence, the rate of use of intrapartum antibiotics was also less, in addition inappropriate nurse: patient ratio and overcrowding also contributed to high sepsis rate.…”

“…Among babies receiving early rescue SRT, survival was 65.45%. Although our gestational age specific survival rates after SRT is comparable to previous studies from India, however, it is lower than that reported from the developed countries [16][17][18]. In a longitudinal study from Korea, mortality was 14.3% for a period of 2007.…”

“…Among babies receiving early rescue SRT, survival was 65.45%. Although our gestational age specific survival rates after SRT is comparable to previous studies from India, however, it is lower than that reported from the developed countries [16–18]. In a longitudinal study from Korea, mortality was 14.3% for a period of 2007.19 High mortality rate seen in our study can be attributed to lack of adequate number of healthcare staff and overcrowding as our centre is the largest referral hospital in northern India.…”

Estrategias de oxigenoterapia y soporte ventilatorio, en cuidado intensivo neonatal post administración de surfactante pulmonar

“…De acuerdo, con lo publicado por varios autores, estos métodos menos invasivos pueden disminuir la necesidad de soporte ventilatorio y la incidencia de Displasia Broncopulmonar, en el manejo clásico de intubación para la administración de surfactante y ventilación mecánica invasiva o no invasiva (34)(35)(36) . Algunos estudios han comparado la técnica INSURE con CPAP y Ventilación Mecánica, en algunos estudios se obtuvieron resultados que confirman que un 46% de recién nacidos pretérminos con SDR pueden ser manejados con la técnica INSURE sin tener en cuenta la ventilación mecánica (37) ; en el estudio de Tsakalidis la experiencia con el manejo de la técnica de INSURE en una UCIN de Grecia, reportó que de 81 prematuros menores de 28 y 32 semanas fueron extubados exitosamente y de ellos el 93,83% no requirieron reintubación (38) . Para este estudio, la técnica de Ventilación Nasal con presión Positiva Intermitente fue empleada en recién nacidos con menos de 30,8 semanas, de acuerdo con la utilización de esta estrategia y según la revisión realizada, esta reduce la incidencia de fracaso de la extubación en 48 horas para siete días (39) .…”

Single dose surfactant early rescue therapy in respiratory distress syndrome-experience and outcome at a tertiary care centre

“…Although our gestational age specific mortality after surfactant replacement therapy was comparable to previous Indian reports, it was higher than western reports. 23,24 We face problems of inappropriate nurse: patient ratios and overcrowding. Overall mortality in surfactant recipient neonates was 25.5% which was inversely related to gestational age (25) which is comparable to other studies from developing world (21-80%).…”

Predictors of mortality in premature babies with respiratory distress syndrome treated by early rescue surfactant therapy

“…Comparison of morbidity profiles revealed higher rates of sepsis (31.8%) in the present study, which was lower than the previous Indian reports, comparable to Korean experience but more than double of a study from a Greece [16–19]. The patients in present study are from low socioeconomic status, although, majority of pregnant mothers (91.8%) were booked prior to the delivery but most of them usually have imminent delivery due to poor educational as well as socioeconomic status, and hence, the rate of use of intrapartum antibiotics was also less, in addition inappropriate nurse: patient ratio and overcrowding also contributed to high sepsis rate.…”

“…Among babies receiving early rescue SRT, survival was 65.45%. Although our gestational age specific survival rates after SRT is comparable to previous studies from India, however, it is lower than that reported from the developed countries [16][17][18]. In a longitudinal study from Korea, mortality was 14.3% for a period of 2007.…”

“…Among babies receiving early rescue SRT, survival was 65.45%. Although our gestational age specific survival rates after SRT is comparable to previous studies from India, however, it is lower than that reported from the developed countries [16–18]. In a longitudinal study from Korea, mortality was 14.3% for a period of 2007.19 High mortality rate seen in our study can be attributed to lack of adequate number of healthcare staff and overcrowding as our centre is the largest referral hospital in northern India.…”

Estrategias de oxigenoterapia y soporte ventilatorio, en cuidado intensivo neonatal post administración de surfactante pulmonar

“…De acuerdo, con lo publicado por varios autores, estos métodos menos invasivos pueden disminuir la necesidad de soporte ventilatorio y la incidencia de Displasia Broncopulmonar, en el manejo clásico de intubación para la administración de surfactante y ventilación mecánica invasiva o no invasiva (34)(35)(36) . Algunos estudios han comparado la técnica INSURE con CPAP y Ventilación Mecánica, en algunos estudios se obtuvieron resultados que confirman que un 46% de recién nacidos pretérminos con SDR pueden ser manejados con la técnica INSURE sin tener en cuenta la ventilación mecánica (37) ; en el estudio de Tsakalidis la experiencia con el manejo de la técnica de INSURE en una UCIN de Grecia, reportó que de 81 prematuros menores de 28 y 32 semanas fueron extubados exitosamente y de ellos el 93,83% no requirieron reintubación (38) . Para este estudio, la técnica de Ventilación Nasal con presión Positiva Intermitente fue empleada en recién nacidos con menos de 30,8 semanas, de acuerdo con la utilización de esta estrategia y según la revisión realizada, esta reduce la incidencia de fracaso de la extubación en 48 horas para siete días (39) .…”

Single dose surfactant early rescue therapy in respiratory distress syndrome-experience and outcome at a tertiary care centre

“…Although our gestational age specific mortality after surfactant replacement therapy was comparable to previous Indian reports, it was higher than western reports. 23,24 We face problems of inappropriate nurse: patient ratios and overcrowding. Overall mortality in surfactant recipient neonates was 25.5% which was inversely related to gestational age (25) which is comparable to other studies from developing world (21-80%).…”