Early Receptor Potential in Dominantly Inherited Retinitis Pigmentosa

Super-resolution ophthalmoscopy: Virtually structured detection for resolution improvement in retinal imaging

“…The high-speed and super-resolution imaging with single photoreceptor resolution also promises a feasible solution to advance functional intrinsic optical signal (IOS) imaging, 31,32 also termed as optophysiology 33 or optoretinography (ORG), 34–36 for objective assessment of retinal physiology. It is known that eye diseases, such as age-related macular degeneration (AMD), 37–39 retinitis pigmentosa (RP), 40,41 diabetic retinopathy (DR), 42,43 can cause photoreceptor dysfunctions. Early detection and therapeutic assessment are essential steps to prevent vision loss due to eye diseases.…”

Super-resolution ophthalmoscopy: Virtually structured detection for resolution improvement in retinal imaging

“…The high-speed and super-resolution imaging with single photoreceptor resolution also promises a feasible solution to advance functional intrinsic optical signal (IOS) imaging, 31,32 also termed as optophysiology 33 or optoretinography (ORG), 34–36 for objective assessment of retinal physiology. It is known that eye diseases, such as age-related macular degeneration (AMD), 37–39 retinitis pigmentosa (RP), 40,41 diabetic retinopathy (DR), 42,43 can cause photoreceptor dysfunctions. Early detection and therapeutic assessment are essential steps to prevent vision loss due to eye diseases.…”

Chapter 6 Negative components of the electroretinogram from proximal retina and photoreceptor

“…The early RP begins 0.7 Msec after an intense stimulus that bleaches much or all of the visual pigment (Cone, 1964), and it is complete within 1.5 msec (Berson, 1987). This short latency suggested a role for the early RP in the signaling of quantum absorption by the visual pigments.…”

“…However, the presence of an early RP in physiologically inert tissues argued against this hypothesis (Brown and Murakami, 1964;Cone, 1964;Brindley and Gardner-Medwin, 1965), and the response now is considered to be an epiphenomenon reflecting charge displacement in the outer segments during the cascade of photochemical reactions following quantum absorption (Cone and Cobbs, 1969). Cones are probably represented more than rods in the response because the pigment molecules in cone outer segments are in disc membranes that are in contact with the extracellular space, whereas pigment molecules in rod outer segments are shielded by the plasma membrane (Berson, 1987).…”

Retinitis pigmentosa and allied diseases: applications of electroretinographic testing

“…13). In sex-linked disease the ERP is reduced more than 85% below normal in a patient only 13 years of age (9). These reductions in the amplitudes of the ERP could be due to reduced outer segment visual pigment concentration or reduced numbers of photoreceptors, or both.…”

“…The early receptor potential (ERP), a rapid biphasic response that precedes the leading edge of the a-wave of the ERG, has also been monitored in the early stages of retinitis pigmentosa (8,9,51). This cone dominated response, generated by the photoreceptor outer segments, is reduced in amplitude in young patients with early retinitis pigmentosa (Fig.…”

Super-resolution ophthalmoscopy: Virtually structured detection for resolution improvement in retinal imaging

“…The high-speed and super-resolution imaging with single photoreceptor resolution also promises a feasible solution to advance functional intrinsic optical signal (IOS) imaging, 31,32 also termed as optophysiology 33 or optoretinography (ORG), 34–36 for objective assessment of retinal physiology. It is known that eye diseases, such as age-related macular degeneration (AMD), 37–39 retinitis pigmentosa (RP), 40,41 diabetic retinopathy (DR), 42,43 can cause photoreceptor dysfunctions. Early detection and therapeutic assessment are essential steps to prevent vision loss due to eye diseases.…”

Chapter 6 Negative components of the electroretinogram from proximal retina and photoreceptor

“…The early RP begins 0.7 Msec after an intense stimulus that bleaches much or all of the visual pigment (Cone, 1964), and it is complete within 1.5 msec (Berson, 1987). This short latency suggested a role for the early RP in the signaling of quantum absorption by the visual pigments.…”

“…However, the presence of an early RP in physiologically inert tissues argued against this hypothesis (Brown and Murakami, 1964;Cone, 1964;Brindley and Gardner-Medwin, 1965), and the response now is considered to be an epiphenomenon reflecting charge displacement in the outer segments during the cascade of photochemical reactions following quantum absorption (Cone and Cobbs, 1969). Cones are probably represented more than rods in the response because the pigment molecules in cone outer segments are in disc membranes that are in contact with the extracellular space, whereas pigment molecules in rod outer segments are shielded by the plasma membrane (Berson, 1987).…”

Retinitis pigmentosa and allied diseases: applications of electroretinographic testing

“…13). In sex-linked disease the ERP is reduced more than 85% below normal in a patient only 13 years of age (9). These reductions in the amplitudes of the ERP could be due to reduced outer segment visual pigment concentration or reduced numbers of photoreceptors, or both.…”

“…The early receptor potential (ERP), a rapid biphasic response that precedes the leading edge of the a-wave of the ERG, has also been monitored in the early stages of retinitis pigmentosa (8,9,51). This cone dominated response, generated by the photoreceptor outer segments, is reduced in amplitude in young patients with early retinitis pigmentosa (Fig.…”

Super-resolution ophthalmoscopy: Virtually structured detection for resolution improvement in retinal imaging

“…The high-speed and super-resolution imaging with single photoreceptor resolution also promises a feasible solution to advance functional intrinsic optical signal (IOS) imaging, 31,32 also termed as optophysiology 33 or optoretinography (ORG), 34–36 for objective assessment of retinal physiology. It is known that eye diseases, such as age-related macular degeneration (AMD), 37–39 retinitis pigmentosa (RP), 40,41 diabetic retinopathy (DR), 42,43 can cause photoreceptor dysfunctions. Early detection and therapeutic assessment are essential steps to prevent vision loss due to eye diseases.…”

Chapter 6 Negative components of the electroretinogram from proximal retina and photoreceptor

“…The early RP begins 0.7 Msec after an intense stimulus that bleaches much or all of the visual pigment (Cone, 1964), and it is complete within 1.5 msec (Berson, 1987). This short latency suggested a role for the early RP in the signaling of quantum absorption by the visual pigments.…”

“…However, the presence of an early RP in physiologically inert tissues argued against this hypothesis (Brown and Murakami, 1964;Cone, 1964;Brindley and Gardner-Medwin, 1965), and the response now is considered to be an epiphenomenon reflecting charge displacement in the outer segments during the cascade of photochemical reactions following quantum absorption (Cone and Cobbs, 1969). Cones are probably represented more than rods in the response because the pigment molecules in cone outer segments are in disc membranes that are in contact with the extracellular space, whereas pigment molecules in rod outer segments are shielded by the plasma membrane (Berson, 1987).…”

Retinitis pigmentosa and allied diseases: applications of electroretinographic testing

“…13). In sex-linked disease the ERP is reduced more than 85% below normal in a patient only 13 years of age (9). These reductions in the amplitudes of the ERP could be due to reduced outer segment visual pigment concentration or reduced numbers of photoreceptors, or both.…”

“…The early receptor potential (ERP), a rapid biphasic response that precedes the leading edge of the a-wave of the ERG, has also been monitored in the early stages of retinitis pigmentosa (8,9,51). This cone dominated response, generated by the photoreceptor outer segments, is reduced in amplitude in young patients with early retinitis pigmentosa (Fig.…”