Early lipid supply and neurological development at one year in very low birth weight (VLBW) preterm infants

Trolli, Sergio Eleni Dit; Kermorvant‐Duchemin, Elsa; Huon, Catherine; Bremond-Gignac, Dominique; Lapillonne, Alexandre

doi:10.1016/j.earlhumdev.2011.12.024

Cited by 69 publications

(50 citation statements)

References 25 publications

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“…Observational study results suggest that improving early parenteral and enteral nutrition to reduce energy and nutrient deficits may improve brain growth, brain maturation and neurodevelopment, especially in EPT and VPT infants. Even after adjusting for confounding factors such as infant gender, birth weight, co-morbidities and maternal education or socioeconomic status, greater cumulative intakes of energy, protein [27], and lipids [18] from both parenteral and enteral sources were associated with better neurodevelopment (as assessed by the Bayley Scales of Infant and Toddler Development (BSID) and Brunet-Lézine test) in these studies. Accordingly, two follow-up studies of the same randomized controlled trial (RCT) on the effect of an early (from less than 24 h of life) enriched parenteral and enteral nutrition on VLBW infant growth [28], showed enhanced white matter maturation at term-equivalent age [29] and improved visual perception at 52 weeks post-menstrual age [30].…”

Section: Dietary Intervention Studies For Brain and Cognitive Devementioning

confidence: 92%

“…One potential approach may be through nutrition, diet and feeding: The rapid growth of the developing brain during fetal and early post-natal life makes it particularly vulnerable to nutritional deficits. The effects of a deficiency or excess of a nutrient on brain and cognitive development depend on the timing, dose, duration of exposure and type of nutrient [18]. In the following sections, we review the findings from randomized and cohort studies.…”

Section: Introductionmentioning

confidence: 99%

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Early Nutritional Interventions for Brain and Cognitive Development in Preterm Infants: A Review of the Literature

Schneider

García-Ródenas

2017

Nutrients

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Adequate nutrition is important for neurodevelopmental outcomes in preterm-born infants. In this review, we aim to summarize the current knowledge on nutritional interventions initiated during the hospital stay targeting brain and cognitive development benefits in preterm human infants. Studies can broadly be split in general dietary intervention studies and studies investigating specific nutrients or nutritional supplements. In general, mother’s breast milk was reported to be better for preterm infants’ neurodevelopment compared to infant formula. The differences in methodologies make it difficult to conclude any effects of interventions with individual nutrients. Only protein and iron level studies showed some consistent findings regarding optimal doses; however, confirmatory studies are needed. This review does not support some widely accepted associations, such as that between long-chain polyunsaturated fatty acid supplementation and visual development. Clear nutritional recommendations cannot be made based on this review. However, the type of infant nutrition (i.e., breast milk versus formula or donor milk), the timing of the nutritional intervention, and the dose of the nutrient/supplement have been found to be relevant factors in determining the success of nutritional intervention studies in preterm infants.

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Section: Dietary Intervention Studies For Brain and Cognitive Devementioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Early Nutritional Interventions for Brain and Cognitive Development in Preterm Infants: A Review of the Literature

Schneider

García-Ródenas

2017

Nutrients

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“…The quality and quantity of daily nutritional intake are critical, particularly during the first weeks of life, since amino acid, energy and lipid intake from parenteral nutrition (PN) have been shown to be associated with later development 3 4. Reports from neonatal intensive care units (NICUs) worldwide have shown that nutritional intake in preterm infants is inadequate 5 6.…”

Section: Introductionmentioning

confidence: 99%

Quality of newborn care: adherence to guidelines for parenteral nutrition in preterm infants in four European countries

et al. 2013

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ObjectiveThe level of adherence to guidelines should be explored particularly in preterm infants for whom poor nutrition has major effects on outcomes in later life. The objective was to evaluate compliance to international guidelines for parenteral nutrition (PN) in preterm infants across neonatal intensive care units (NICUs) of four European countries.DesignClinical practice survey by means of a questionnaire addressing routine PN protocols, awareness and implementation of guidelines.SettingNICUs in the UK, Italy, Germany and France.ParticipantsOne senior physician per unit; 199 units which represent 74% of the NICUs of the four countries.Primary outcome measureAdherence of unit protocol to international guidelines.Secondary outcome measureFactors that influence adherence to guidelines.Results80% of the respondents stated that they were aware of some PN clinical practice guidelines. For amino acid infusion (AA), 63% of the respondents aimed to initiate AA on D0, 38% aimed to administer an initial dose ≥1.5 g/kg/day and 91% aimed for a target dose of 3 or 4 g/kg/day, as recommended. For parenteral lipids, 90% of the respondents aimed to initiate parenteral lipids during the first 3 days of life, 39% aimed to use an initial dose ≥1.0 g/kg/day and 76% defined the target dose as 3–4 g/kg/day, as recommended. Significant variations in PN protocols were observed among countries, but the type of hospital or the number of admissions per year had only a marginal impact on the PN protocols.ConclusionsMost respondents indicated that their clinical practice was based on common guidelines. However, the initiation of PN is frequently not compliant with current recommendations, with the main differences being observed during the first days of life. Continuous education focusing on PN practice is needed, and greater efforts are required to disseminate and implement international guidelines.

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“…Both macronutrient and energy intakes are associated with weight, length, and head circumference gains during initial hospitalization . Protein, lipid, and energy intakes in VLBW infants during the first week of life have been shown to be associated with improved neurodevelopment . Furthermore, exposure to mother’s milk and energy and lipid intake during the first 28 days of life have been associated with a reduction in late‐onset sepsis and retinopathy of prematurity (ROP) .…”

Section: Introductionmentioning

confidence: 99%

Neonatal Morbidity Count Is Associated With a Reduced Likelihood of Achieving Recommendations for Protein, Lipid, and Energy in Very Low Birth Weight Infants: A Prospective Cohort Study

Unger

Asbury

et al. 2017

J Parenter Enteral Nutr

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Early lipid supply and neurological development at one year in very low birth weight (VLBW) preterm infants

Cited by 69 publications

References 25 publications

Early Nutritional Interventions for Brain and Cognitive Development in Preterm Infants: A Review of the Literature

Early Nutritional Interventions for Brain and Cognitive Development in Preterm Infants: A Review of the Literature

Quality of newborn care: adherence to guidelines for parenteral nutrition in preterm infants in four European countries

Neonatal Morbidity Count Is Associated With a Reduced Likelihood of Achieving Recommendations for Protein, Lipid, and Energy in Very Low Birth Weight Infants: A Prospective Cohort Study

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