Early life PCB138 exposure induces kidney injury secondary to hyperuricemia in male mice

Ruan, Fengkai; Liu, Changqian; Hu, Weiping; Ruan, Jinpeng; Ding, Xiaoyan; Zhang, Lu; Yang, Chunyan; Zuo, Zhenghong; He, Chengyong; Huang, Jian

doi:10.1016/j.envpol.2022.118977

Cited by 11 publications

(2 citation statements)

References 75 publications

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“…PCBs have been used in various industries, including as pesticide additives. They have been associated with metabolic disorders, neurotoxicity, liver toxicity, and reproductive and developmental toxicity [33]. This study detected PCB-28, -52, -101, -118, -153, -138, -180, and -202 levels.…”

Section: Discussionmentioning

confidence: 63%

Investigation of the Relationship between Spontaneous Abortion, Serum Pesticides, and Polychlorinated Biphenyl Levels

Akgöl,

Kanat Pektaş

2023

Toxics

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Occupational and environmental chemical exposure have been associated with adverse reproductive consequences. This study investigates the relationship between spontaneous abortion and blood pesticide and polychlorinated biphenyl (PCB) levels. A survey was conducted, and blood samples were collected from 200 patients, consisting of 100 cases with spontaneous abortion and 100 cases with normal deliveries. A total of 150 different pesticides, including organophosphates, organochlorines, carbamates, and pyrethroids, were screened in the collected blood samples and analyzed quantitatively using Tandem mass spectrometry—specifically in combination with liquid chromatography and gas chromatography–tandem mass spectrometry methods. Eight types of PCBs were analyzed with the gas chromatography-tandem mass spectrometry method. The groups were compared based on these analyses. The mean age of the participants was 28.09 ± 4.94 years. In 59% of the spontaneous abortion group, 5.05 ± 1.97 chemicals were detected in different amounts. (p < 0.05). Analysis of the samples identified the presence of β-Hexachlorocyclohexane (β-HCH), delta-hexachlorocyclohexane (δ HCH), Hexachlorobenzene (HCB), Pentachlorobiphenyl-28 (PCB-28), Pentachlorobiphenyl-52 (PCB-52), o,p′-Dichlorodiphenyldichloroethylene (o,p′-DDE), p,p′-Dichlorodiphenyldichloroethylene (p,p’DDE), o,p′-Dichlorodiphenyldichloroethane (o,p′-DDD), p,p′-Dichlorodiphenyldichloroethane (p,p′-DDD), Pentachlorobiphenyl-118 (PCB-118), Pentachlorobiphenyl-101 (PCB-101), Pentachlorobiphenyl-153 (PCB-153), Pentachlorobiphenyl-138 (PCB-138), Pentachlorobiphenyl-202 (PCB-202), Pentachlorobiphenyl-180 (PCB-180) as well as Fibronil, Buprimate, Acetoclor, Acemiprid, Pentimanthalin, and Triflokystrobin. The spontaneous abortion group had significantly higher exposure to PCB-101, PCB-52, PCB-138, and δ-HCH (p < 0.05). Women included in the study had high pesticide and PCB exposure rates. Many of the blood samples contained multiple pesticides with endocrine-disrupting effects. Higher exposure to organochlorine compounds in the serum was identified in the group with spontaneous abortions.

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Section: Discussionmentioning

confidence: 63%

Investigation of the Relationship between Spontaneous Abortion, Serum Pesticides, and Polychlorinated Biphenyl Levels

Akgöl,

Kanat Pektaş

2023

Toxics

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“…Polybrominated diphenyl ethers (PBDEs), which have similar structures to PCB, have also been associated with renal histopathological changes [ 37 ] and significantly reduced catalase activity [ 38 ]. Exposure of infant mice to PCB caused hyperuricemia in adults, leading to secondary nephrotoxicity such as renal hypertrophy and fibrosis [ 39 ]. After 12 days of exposure, the combined exposure to TCDD and PCB was more likely to induce nephrotoxicity through high expression of CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1), compared with the control group (equivalent volume of olive oil).…”

Section: Dioxinmentioning

confidence: 99%

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Zhang

Flaws

Spinella

et al. 2022

Toxics

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Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.

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Associations of polychlorinated biphenyl and organochlorine pesticide exposure with hyperuricemia: modification by lifestyle factors

Fan,

Liu,

et al. 2023

Environ Sci Pollut Res

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Early life PCB138 exposure induces kidney injury secondary to hyperuricemia in male mice

Cited by 11 publications

References 75 publications

Investigation of the Relationship between Spontaneous Abortion, Serum Pesticides, and Polychlorinated Biphenyl Levels

Investigation of the Relationship between Spontaneous Abortion, Serum Pesticides, and Polychlorinated Biphenyl Levels

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Associations of polychlorinated biphenyl and organochlorine pesticide exposure with hyperuricemia: modification by lifestyle factors

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