volume 8, issue 9, P2039-2061 2016
DOI: 10.18632/aging.101043
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Thalia S. Field, Fergus N. Doubal, Wendy Johnson, Ellen Backhouse, Caroline McHutchison, Simon Cox, Janie Corley, Alison Pattie, Alan J. Gow, Susan Shenkin, Vera Cvoro, Zoe Morris, Julie Staals, Mark Bastin et al.

Abstract: It is unknown whether relations between early-life factors and overall health in later life apply to burden of cerebral small vessel disease (cSVD), a major cause of stroke and dementia. We explored relations between early-life factors and cSVD in the Lothian Birth Cohort, a healthy aging cohort. Participants were recruited at age 70 (N = 1091); most had completed a test of cognitive ability at age 11 as part of the Scottish Mental Survey of 1947. Of those, 700 participants had brain MRI that could be rated fo…

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