2016
DOI: 10.18632/aging.101043
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Abstract: It is unknown whether relations between early-life factors and overall health in later life apply to burden of cerebral small vessel disease (cSVD), a major cause of stroke and dementia. We explored relations between early-life factors and cSVD in the Lothian Birth Cohort, a healthy aging cohort. Participants were recruited at age 70 (N = 1091); most had completed a test of cognitive ability at age 11 as part of the Scottish Mental Survey of 1947. Of those, 700 participants had brain MRI that could be rated fo… Show more

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Cited by 21 publications
(17 citation statements)
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References 64 publications
(76 reference statements)
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“…There is increasing evidence that a total cSVD MRI burden score, which summarizes individual cSVD markers in a compound scale, might better reflect the global overall effect of cSVD on the brain. [11][12][13][14]20,21 A study 22 in older subjects with vascular risk factors showed that concurrent gait function, measured by Unified Parkinson's Disease Rating Scale, 23 was associated with total cSVD burden. This was the first study looking at concurrent gait function and overall cSVD burden (but not after stroke), although the cSVD burden score was incomplete as they did not include PVS.…”
Section: Discussionmentioning
confidence: 99%
“…There is increasing evidence that a total cSVD MRI burden score, which summarizes individual cSVD markers in a compound scale, might better reflect the global overall effect of cSVD on the brain. [11][12][13][14]20,21 A study 22 in older subjects with vascular risk factors showed that concurrent gait function, measured by Unified Parkinson's Disease Rating Scale, 23 was associated with total cSVD burden. This was the first study looking at concurrent gait function and overall cSVD burden (but not after stroke), although the cSVD burden score was incomplete as they did not include PVS.…”
Section: Discussionmentioning
confidence: 99%
“…Initial efforts were further tested and refined in larger datasets of patients with stroke and healthy older individuals, testing inclusion of additional features and different weighting of individual feature scores, with the Edinburgh group [11, 17, 18]. In the current version of the score, a point is attributed for each of the following: moderate to severe WMH, presence of moderate to severe PVS in the basal ganglia, presence of lacunes and presence of microbleeds.…”
Section: Methods For This Reviewmentioning
confidence: 99%
“…From the attempts to devise a composite SVD score representative of the individual’s SVD burden, a major effort has been made by Staals and colleagues [ 27 •], based on visually rated individual SVD features and combines them into the ‘total SVD burden’ on a scale of 0–4 [ 27 •]. Initial efforts were further tested and refined in larger datasets of patients with stroke and healthy older individuals, testing inclusion of additional features and different weighting of individual feature scores, with the Edinburgh group [ 11 , 17 , 18 ]. In the current version of the score, a point is attributed for each of the following: moderate to severe WMH, presence of moderate to severe PVS in the basal ganglia, presence of lacunes and presence of microbleeds.…”
Section: Methods For This Reviewmentioning
confidence: 99%
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“…In line with the studies referenced above, we hypothesize that in this cohort of septuagenarian individuals' hippocampal morphology, and specifically lateral deformations on the surface of the hippocampal head, will be associated with specific memory ability and also with broader cognitive domains. Given prior evidence in the hippocampus (Tang et al., 2016) and associations between earlier life intelligence and other MRI phenotypes in this cohort (e.g., Cox et al., 2016, Field et al., 2016), we further hypothesize that precursors of these deformations could be found at childhood.…”
Section: Introductionmentioning
confidence: 99%