Early life adversity promotes gastrointestinal dysfunction through a sex-dependent phenotypic switch in enteric glia
Jacques Gonzales,
Christine Dharshika,
Khadijah Mazhar
et al.
Abstract:Irritable bowel syndrome and related disorders of gut-brain interaction (DGBI) are common and exhibit a complex, poorly understood etiology that manifests as abnormal gut motility and pain. Risk factors such as biological sex, stressors during critical periods, and inflammation are thought to influence DGBI vulnerability by reprogramming gut-brain circuits, but the specific cells affected are unclear. Here, we used a model of early life stress to understand cellular mechanisms in the gut that produce DGBIs. Ou… Show more
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