2006
DOI: 10.1590/s0074-02762006000400010
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Abstract: A cross-sectional study was conducted in order to identify hepatitis A virus (HAV) serological markers in 418 individuals (mean age, 16.4 years; range, 1 month-80 respectively, in 89.5% (374/418) and 10.5% (44/418) IA and IB in 93.3% (28/30) Hepatitis A virus (HAV) is a hepatotropic virus and a member of the Hepatovirus genus within the Picornaviridae family (Minor 1991). The virus is responsible for the majority of the acute hepatitis cases in Brazil (Gaspar et al. 1996), and infection symptoms are ag… Show more

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Cited by 15 publications
(19 citation statements)
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References 24 publications
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“…31 In urban areas such as the metropolitan area of Rio de Janeiro, outbreaks of hepatitis A have been described due to the exposure of susceptible population. [32][33][34][35] Nevertheless, epidemic HEV infections have not been yet found. The human HEV isolate (Brazil h1) from this study clustered with two swine strains (Brazil sw1 and Brazil sw2) also from Rio de Janeiro and a human Japanese isolate (E21-YKH00) from an sporadic acute case of genotype 3 and subtype 3b according to a classification proposed by Lu and Li.…”
Section: Discussionmentioning
confidence: 99%
“…31 In urban areas such as the metropolitan area of Rio de Janeiro, outbreaks of hepatitis A have been described due to the exposure of susceptible population. [32][33][34][35] Nevertheless, epidemic HEV infections have not been yet found. The human HEV isolate (Brazil h1) from this study clustered with two swine strains (Brazil sw1 and Brazil sw2) also from Rio de Janeiro and a human Japanese isolate (E21-YKH00) from an sporadic acute case of genotype 3 and subtype 3b according to a classification proposed by Lu and Li.…”
Section: Discussionmentioning
confidence: 99%
“…Hepatitis A is transmitted by the faecal‐oral route, is responsible for the majority of viral hepatitis cases worldwide and is recognized as an important public health disease, especially in intermediate endemic regions [FitzSimons et al, 2010]. Due to public health improvements and better socioeconomic conditions, there has been a decline in HAV endemicity over the past few decades in Brazil [Tanaka, 2000; Villar et al, 2004; Morais et al, 2006; Vitral et al, 2006]. This decline decreases the incidence of natural immunization and creates a potential for massive outbreaks in closed communities such as schools and daycare centers [Villar et al, 2002; de Paula et al, 2002; Morais et al, 2006].…”
Section: Introductionmentioning
confidence: 99%
“…Due to public health improvements and better socioeconomic conditions, there has been a decline in HAV endemicity over the past few decades in Brazil [Tanaka, 2000; Villar et al, 2004; Morais et al, 2006; Vitral et al, 2006]. This decline decreases the incidence of natural immunization and creates a potential for massive outbreaks in closed communities such as schools and daycare centers [Villar et al, 2002; de Paula et al, 2002; Morais et al, 2006]. These institutions play an important role in the HAV chain of transmission due to the asymptomatic nature of the infection in children younger than 6 years old, which may lead to silent dissemination of the disease among susceptible adults [Desenclos and MacLafferty, 1993; Venczel et al, 2001; Poovorawan et al, 2005].…”
Section: Introductionmentioning
confidence: 99%
“…In the county of Belford Roxo, 26 HAV isolates had a 168 bp fragment of VP1/2A junction sequenced and most of them (61.5%) belonged to subgenotype IA that comprises over 80% of strains isolated worldwide (Robertson et al 1992 Morais et al 2006) and another one that occurred in a public school in the county of Paracambi (Rio de Janeiro) (Villar et al 2002). In the county of Belford Roxo, subgenotype IB was detected from January 2000 till November 2000 and all isolates shared the same homology suggesting a common source of infection.…”
Section: Discussionmentioning
confidence: 99%