Early House Dust Mite Sensitivity in Mumbai Children

Doshi, Arpit; Tripathi, DM

doi:10.1007/s12098-015-1952-7

Cited by 15 publications

(11 citation statements)

References 15 publications

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“…These findings might be attributable to the natural history of atopic disorders (atopic march) where exposure to outdoor allergens occurring in later childhood. This is similar to the observation by Al-Zayadneh et al who reported SPT positivity increasing significantly with age [19,23]. Aeroallergen sensitization in wheezing children (n=100) was studied by Pendino et al and found sensitization to dust mite, pollen, and mold to be 58%, 13%, and 8% respectively [24].…”

Section: Discussionsupporting

confidence: 87%

“…D. pteronyssinus and D. farinae are the two predominant mites tested in the present study with a positivity rate of 22.5% and 21.3%, respectively. Doshi and Tripathi and Al-Zayadneh et al reported the most predominant mite to be D. pteronyssinus similar to our study [19,23]. However, Luo et al reported significantly high positivity in SPT for D. farinae as compared to D. pteronyssinus (50.0% vs. 14.7%; P<0.05) [20].…”

Section: Discussionsupporting

confidence: 85%

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Prevalence of Allergic Sensitization in Childhood Asthma

Meher¹,

Pradhan²,

Mahar³

et al. 2021

Cureus

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The allergic sensitization in childhood asthma is common and the prevalence varies in different geographical locations. The data on allergen sensitization to guide clinicians on allergy avoidance is limited. MethodThis prospective observational study was conducted between October 2019 and April 2020 on children aged two to 14 years attending an outpatient clinic. Those with recurrent wheezing or physician-diagnosed asthma were interviewed; eosinophil count, total serum immunoglobulin E (IgE) was measured; and skin prick test (SPT) was done using standardized reagents. Wheal size of ≥3mm was considered positive. ResultsA total of 80 children were enrolled. The mean age was 71.15 ± 33.52 months (M:F ratio =1.96:1). Allergic rhinitis, conjunctivitis, and dermatosis were seen in 76 (95.0%), 33 (41.3%), and 22 (27.5%) cases, respectively. The mean absolute eosinophil count was 576 ± 427per cmm. The mean total IgE was 800.9 ± 883.2IU/ml. Seasonal and diurnal variations were found in 34 (42.5%) and 79 (98.8%) cases. Out of 1753 skin pricks using 27 reagents, 355 (20.25%) were positive. Increasing age was significantly associated with increasing SPT positivity (P = 0.0001). The most common sensitive aeroallergens were Kentucky bluegrass (25%), Dermatophagoides pteronyssinus (22.5%), Dermatophagoides farinae (21.3%), Timothy grass, and Alternaria alternans (20% each). The most common sensitive food allergens were spinach (25%), banana (22.5%), carp (20%), shrimp and hen's egg (18.8% each), and cow's milk (17.5%). ConclusionIncreasing age was associated with increasing SPT positivity in childhood asthma. The most common sensitive aeroallergens were Kentucky bluegrass and Dermatophagoides pteronyssinus; spinach and banana were the most common food allergen.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 85%

Prevalence of Allergic Sensitization in Childhood Asthma

Meher¹,

Pradhan²,

Mahar³

et al. 2021

Cureus

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“…It has also been concluded that the most common cause of sensitization in allergic patients was D. pteronyssinus mite followed by D. farinae, D. microceras and D. aureliani. The above findings are in accordance with the findings of Sun et al (2014), Doshi and Tripathi (2016) and Miller (2018). Study done by Miller (2018) showed that house dust mites are the main cause of atopic sensitization and allergic disorders throughout the world.…”

Section: B Composition Of Identified Mite Faunasupporting

confidence: 90%

Allergenic Co-inhabitants of House Dust

Dhaliwal¹,

Gill²

2020

JSR

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Indoor level of house dust mite allergens play a key role for the development and persistence of asthma and atopic sensitivity. The qualitative and quantitative knowledge of these allergens in a given region is of great importance as they cause several respiratory allergic diseases and skin allergic diseases when inhaled. House dust mites which are responsible for allergic disorders have been reported from various regions of India but the studies are scanty and scattered. Similarly, very few studies have been carried out in North India. Present study was conducted on 300 patients diagnosed with allergic rhinitis and allergic asthma. Total 756 dust samples were collected from the homes of 300 patients. Out of these, 544 dust samples were found to be positive for mites. From the positive dust samples 24,704 mite specimens were collected, out of these 21,588 mites i.e. 87.39 % from order Sarcoptiformes, hyporder Astigmata and family Pyroglyphidae. During present study 4 species of Astigmatic mites have been identified. These were Dermatophagoides pteronyssinus i.e. 61.74%, D. farinae i.e. 18.33%, D. microceras i.e. 6.21%, D. aureliani i.e. 1.11% whereas only 3116 i.e. 12.61% mite were belonging to other orders. Present study reported Dermatophagoides pteronyssinus, D. farinae D. microceras and D. aureliani as Co-inhabitants. These four species belonging to genera Dermatophagoides were found Coinhabiting in almost all the samples.

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“…Aeroallergen sensitization patterns in atopic individuals in various Asian countries, namely China, Hong Kong, India, Japan, Korea, Malaysia, Philippines, Singapore, Taiwan, Thailand and Vietnam are shown in the Table 1 and Figure 1. 5,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] No published data from Myanmar, Laos and Cambodia were available. Studies involving aeroallergen distribution alone without human sensitization, and those involving sensitization without associated atopy were not included.…”

Section: Aeroallergen Sensitization Patterns In Asian Countriesmentioning

confidence: 99%

Aeroallergen sensitization and allergic disease phenotypes in Asia

Tham

Lee

Bever

2016

Asian Pac J Allergy Immunol

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Allergic diseases are on the rise in Asia. Aeroallergen exposure is a strong risk factor for sensitization, development and severity of atopic diseases, especially in the Asian paediatric population. Geographical and seasonal variations in aeroallergen sensitization are seen even within Asian countries and changes in aeroallergen sensitization patterns have been observed over time. Some possible reasons include climate change as well as rapid urbanization and improved sanitation which follow socioeconomic development. House dust mite allergy is present in up to 90% of Asian atopic patients, far exceeding that which is seen in Western populations which report prevalences of only 50% to 70%. Pollen and animal dander affect less than 10% of Asian patients as compared to 40-70% of individuals with asthma and allergic rhinitis living in the West, a burden almost equivalent to the dust mite burden in those regions. There is thus a pressing need for preventive measures to reduce dust mite sensitization in Asian children today.

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Early House Dust Mite Sensitivity in Mumbai Children

Abstract: Children in Mumbai show early sensitization to HDM. D. pteronyssinus is the commonest offending allergen in the index study.

Cited by 15 publications

References 15 publications

Prevalence of Allergic Sensitization in Childhood Asthma

Prevalence of Allergic Sensitization in Childhood Asthma

Allergenic Co-inhabitants of House Dust

Aeroallergen sensitization and allergic disease phenotypes in Asia

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