1987
DOI: 10.2307/3282344
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Abstract: The extracellular promastigote stage of Leishmania donovani is inoculated by a phlebotomine sandfly into the skin of a susceptible host, after which visceral dissemination and clinical disease may ensue. Using a hamster model we examined the histopathology of early infection with L. donovani after intradermal inoculation of cultured promastigotes. The initial response was a mixed polymorphonuclear (PMN)-mononuclear phagocyte infiltrate, noted between 1 and 24 hr after inoculation, which became primarily mononu… Show more

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Cited by 73 publications
(64 citation statements)
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“…In contrast to the wild-type mice, for which amastigotes were found only in macrophages, the intracellular amastigotes in the immunodeficient animals were variably associated with neutrophils, eosinophils, and dendritic leukocytes, which in the case of neutrophils and eosinophils harbored large numbers of parasites. Dendritic cells recovered from lymphoid tissue have been found to harbor persistent L. major (55), and transient or low multiplicity infections in neutrophils and eosinophils have been noted within cutaneous lesions (56,57). Our results in the immunodeficient mice extend these findings by suggesting that neutrophils and eosinophils are under some circumstances capable of supporting sustained, productive intracellular infections.…”
Section: Discussionsupporting
confidence: 78%
“…In contrast to the wild-type mice, for which amastigotes were found only in macrophages, the intracellular amastigotes in the immunodeficient animals were variably associated with neutrophils, eosinophils, and dendritic leukocytes, which in the case of neutrophils and eosinophils harbored large numbers of parasites. Dendritic cells recovered from lymphoid tissue have been found to harbor persistent L. major (55), and transient or low multiplicity infections in neutrophils and eosinophils have been noted within cutaneous lesions (56,57). Our results in the immunodeficient mice extend these findings by suggesting that neutrophils and eosinophils are under some circumstances capable of supporting sustained, productive intracellular infections.…”
Section: Discussionsupporting
confidence: 78%
“…To our knowledge, clinical symptoms of VL in hamsters have been observed only 10 months after i.d. inoculation of L. donovani in the abdomen (25). Moreover, it has been established that adult hamsters (3-4 months old) are less susceptible to VL infection (27,28).…”
Section: Discussionmentioning
confidence: 99%
“…However, these routes of infection do not mimic natural transmission by sand fly bite where the parasites are delivered into the skin of a mammalian host in the presence of saliva. To our knowledge, apart from a single study reported over a decade ago (25) there is no animal model for VL that combines this natural route of transmission with fatal disease progression. In this work, we demonstrate the fatal outcome of VL in 3-to 4-month-old naïve hamsters after intradermal (i.d.)…”
mentioning
confidence: 99%
“…Further infection, through the intradermal or subcutaneous route that more closely approximates the natural course of infection due to transmission by the bite of a phlebotomine sand fly, has been achieved in some dogs and in the highly susceptible hamster model (30,74). However, the establishment of visceral infection through intradermal infection in the mouse model remains controversial (41,52,61).…”
mentioning
confidence: 99%