Early experiences using bromelain-based enzymatic debridement in a tertiary burns centre in the United Kingdom: A retrospective case series review

Arkoulis, Nikolaos; Mabvuure, Nigel Tapiwa; Smith, Alex; Barnes, David

doi:10.1016/j.bjps.2020.12.028

Cited by 8 publications

(8 citation statements)

References 18 publications

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“…Hofmaenner et al [14] reported no evident systemic findings in cases where the burn area was more than 15% of the enzymatic debridement. A study by Arkoulis et al [15] stated that bromelain-based enzymatic debridement is a valuable tool in the burn unit. However, there is a need for studies that provide substantial evidence for its superiority to surgery.…”

Section: Discussionmentioning

confidence: 99%

The effect of COVID-19 in a newly established burn center

2021

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Objective This study aims to investigate the effects of COVID-19 on epidemiological features, burn agent, burn percentage, and hospitalization time in a burn center. Methods This single-center, retrospective study included a total of 401 patients admitted to our study center between October 2019 and July 2020. The patients who were admitted before March 1, 2020, were considered the pre-March group, and those who were admitted after March 1, 2020, were considered the post-March group. According to their age, the patients were further divided into groups as those aged ≤ 18 years and those aged > 18 years. Demographic and clinical characteristics of patients, burn agent, burn surface area, COVID-19 status, and treatment and follow-up data were recorded. Results Our study results showed no significant difference in the number of patient admission, age, and sex of patients, burn agents and length of hospital stay before and after the COVID-19 outbreak. Conclusions Burn centers can work safely in COVID-19 outbreak, paying special attention to precautions mandated by the national and global health authorities. However, the increase in pandemic burden may force the burn centers to be converted into alternate COVID-19 facilities. In such cases, the care of burn patients may pose a great problem.

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Section: Discussionmentioning

confidence: 99%

The effect of COVID-19 in a newly established burn center

2021

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“…Since the market approval of NXB, several studies have been published reporting positive and satisfying results in various burn depths, manifesting the additional value of ED in context of initial handling of burn injuries [20,22,66,68,69,[84][85][86][87][88][89][90][91]. While initially intended to prevent the requirement of skin grafting, ED is now ordinarily used for general and decent debridement independently of the planned therapeutic regime.…”

Section: Results and Advantagesmentioning

confidence: 99%

Role, Development, and Value of Enzymatic Debridement as Integral Component in Initial Treatment of Burn Injuries Exemplified by NexoBrid®

Mattern

Fuchs

Schiefer

2022

EBJ

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Despite intensive research and increased knowledge over the past decades, the handling of severe burn injuries remains complex and is mainly based on clinical experience. High demands in terms of the diagnosis and choice of therapy often confront clinicians with challenging circumstances. Thus, the treatment of burn injuries has predominantly remained under the responsibility of specialised centres. As a new approach in addition to conventional surgery, enzymatically controlled debridement has come into focus for the treatment of burn injuries over the past years. The efficacy and safety of enzymatic debridement has already been implemented by numerous reputable studies. Promising results from the literature are enhanced by feedback from various conference contributions, intradisciplinary exchanges, and international collaborations. The implementation of enzymatic debridement in initial care management was found to be capable of reforming Standards of Care in numerous burn centres by facilitating treatment determinations and reducing the number of classical surgical interventions. Nevertheless, its use is also subject to certain restrictions as usage has shown limitations concerning efficacy when applied to scalds or pre-treated wounds. Enzymatic debridement shows high efficacy in terms of tissue debridement by combining this feature with the minimisation of collateral damage and a broad field of application in burn injuries. Due to their impressive performance in the treatment of burn injuries, enzyme-based techniques have also attracted attention for the treatment of other pathologies such as chronic wounds and are objects of ongoing research in this field. In this article, we illustrate the significance of enzyme-based treatment in initial burn care and shed some light on the potential value of enzymatic approaches in future burn surgery.

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“…8 ). 52 54 It was developed by Dr. Lior Rosenberg, former Chair of the Department of Plastic Surgery, Soroka University Hospital.…”

Section: Wound Managementmentioning

confidence: 99%

“…52 NexoBrid application has proven to be an effective technique for managing burn eschars. 49,52,[54][55][56] This enzymatic debridement agent selectively debrides nonviable tissue and preserves unscathed deep dermal tissue, which can epithelialize without undergoing additional autografting. 52 It has been used to manage burns across various anatomical areas from the perineum to the distal extremities with a predilection for improved outcomes in burns with total body surface areas less than 15%.…”

Section: Nexobrid Mediwound Ltd Yavne Israelmentioning

confidence: 99%

Israeli Innovations in the Field of Plastic Surgery

et al. 2022

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Numerous innovations within the field of plastic surgery have been developed in Israel over the last few decades. Many of these therapeutic devices and techniques have been established globally with demonstrable efficacy and respectable safety profiles. This article offers an overview of recent Israeli cutting-edge medical therapeutic solutions contributing to the global practice of plastic surgery.

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Early experiences using bromelain-based enzymatic debridement in a tertiary burns centre in the United Kingdom: A retrospective case series review

Cited by 8 publications

References 18 publications

The effect of COVID-19 in a newly established burn center

The effect of COVID-19 in a newly established burn center

Role, Development, and Value of Enzymatic Debridement as Integral Component in Initial Treatment of Burn Injuries Exemplified by NexoBrid®

Israeli Innovations in the Field of Plastic Surgery

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