Early diagnosis of mild cognitive impairment and Alzheimer’s with event-related potentials and event-related desynchronization in N-back working memory tasks

Fraga, Francisco J.; Mamani, Godofredo Quispe; Johns, Erin; Tavares, Guilherme; Falk, Tiago H.; Phillips, Natalie A.

doi:10.1016/j.cmpb.2018.06.011

Cited by 51 publications

(36 citation statements)

References 92 publications

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“…Although rarely investigated, some studies examined the late positive component (LPC, aka P600), the parietal old/new effect, late slow waves, the late positive potential (LPP), and some other uncommon components (e.g., N250r, C250, contingent negative variation (CNV)). Study of components with less than three supporting articles are not comprehensively discussed [e.g., 21,24,27,44], but are included in Tables 1 and 2. Running head: SYSTEMATIC REVIEW OF COGNITIVE ERPS IN MCI AND AD…”

Section: Resultsmentioning

confidence: 99%

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

Paitel

Samii

Nielson

2021

Behavioural Brain Research

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This systematic review examined whether event-related potentials (ERPs) during higher cognitive processing can detect subtle, early signs of neurodegenerative disease. Original, empirical studies retrieved from PsycINFO and PubMed were reviewed if they analyzed patterns in cognitive ERPs (³150ms post-stimulus) differentiating mild cognitive impairment (MCI), Alzheimer's disease (AD), or cognitively intact elders who carry AD risk through the Apolipoprotein-E ε4 allele (ε4+) from healthy older adult controls (HC). The 100 studies meeting inclusion criteria (MCI=47; AD=47; ε4+=6) analyzed N200, P300, N400, and occasionally, later components. While there was variability across studies, patterns of reduced amplitude and delayed latency were apparent in pathological aging, consistent with AD-related brain atrophy and cognitive impairment. These effects were particularly evident in advanced disease progression (i.e., AD > MCI) and in later ERP components measured during complex tasks. Although ERP studies in intact ε4+ elders are thus far scarce, a similar pattern of delayed latency was notable, along with a contrasting pattern of increased amplitude, consistent with compensatory neural activation. This limited work suggests ERPs might be able to index early neural changes indicative of future cognitive decline in otherwise healthy elders. As ERPs are also accessible and affordable relative to other neuroimaging methods, their addition to cognitive assessment might substantively enhance early identification and characterization of neural dysfunction, allowing opportunity for earlier differential diagnosis and targeting of intervention. To evaluate this possibility there is urgent need for well-powered studies assessing late cognitive ERPs during complex tasks, particularly in healthy elders at risk for cognitive decline.

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Section: Resultsmentioning

confidence: 99%

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

Paitel

Samii

Nielson

2021

Behavioural Brain Research

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“…This test includes 200 trials which include 40 target stimuli. Each stimulus will last for 600 ms, and then a blank screen of 1400 ms will be used as the stimulus interval [ 31 ]. The mission was edited and implemented by E-prime 3 and will be displayed on a 24-in.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of theta and gamma electroacupuncture for post-stroke patients on working memory and electrophysiology: study protocol for a double-center, randomized, patient- and assessor-blinded, sham-controlled, parallel, clinical trial

Ren

Zhao

et al. 2020

Trials

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Background Practitioners of complementary and alternative medicine have suggested that electroacupuncture (EA) could improve post-stroke cognitive impairment, based on the clinical evidence. This study protocol is aimed at showing the effectiveness of theta and gamma EA for post-stroke patients on working memory (WM) and electrophysiology. Methods After assessing their eligibility, 66 patients with stroke will be enrolled from two Chinese medicine hospitals and randomly divided into theta frequency EA group, gamma frequency EA group, and sham-EA group according to the ratio of 1:1:1. All patients will receive 20 sessions of EA procedures for 4 weeks. Patients in three groups will receive EA at two same acupoints in the head: Baihui (GV20) and Shenting (GV24). The frequency of the three groups of EA is set as follows: 6 Hz (theta-EA group), 40 Hz (gamma-EA group), and no current through the electrodes (sham EA). Patients and assessors will be blinded throughout the entire study. The primary outcome is the performance accuracy of 1-back task which is a frequently used measure of WM in cognitive neuroscience research contexts. Secondary outcome measures will include the response time of 1-back task, the Rivermead Behavioral Memory Test, Trail Making Test, Loewenstein Occupational Therapy Cognitive Assessment Scale, modified Barthel Index, and electroencephalogram (EEG) signals during 1-back tasks. A blinding index will be assessed. Data will be statistically analyzed by one-way ANOVA, at 5% of significance level. Discussion We expect this double-center, randomized, patient- and assessor-blinded, sham-controlled, parallel, clinical trial to explore the effectiveness of theta and gamma EA therapy, compared with sham EA, for post-stroke WM. Trial registration Chinese Clinical Trial Registry, ChiCTR2000031995. Registered on 17 April 2020.

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“…Therefore, performance of simple behavioral tasks may result in discomfort and inability to complete the task (31). In a study by Fraga et al (32), EEG was used to discriminate among elderly healthy controls (HC; n = 27), MCI (n = 21) and AD (n = 15). This study used EEG analysis during an executive function task (a working memory task).…”

Section: Electroencephalographymentioning

confidence: 99%

Potential New Approaches for Diagnosis of Alzheimer's Disease and Related Dementias

et al. 2020

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Dementia is an umbrella term-caused by a large number of specific diagnoses, including several neurodegenerative disorders. Alzheimer's disease (AD) is now the most common cause of dementia in advanced countries, while dementia due to neurosyphilis was the leading cause a century ago. Many challenges remain for diagnosing dementia definitively. Some of these include variability of early symptoms and overlap with similar disorders, as well as the possibility of combined, or mixed, etiologies in some cases. Newer technologies, including the incorporation of PET neuroimaging and other biomarkers (genomics and proteomics), are being incorporated into revised diagnostic criteria. However, the application of novel diagnostic methods at clinical sites is plagued by many caveats including availability and access. This review surveys new diagnostic methods as well as remaining challenges-for clinical care and clinical research.

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Early diagnosis of mild cognitive impairment and Alzheimer’s with event-related potentials and event-related desynchronization in N-back working memory tasks

Cited by 51 publications

References 92 publications

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

Effectiveness of theta and gamma electroacupuncture for post-stroke patients on working memory and electrophysiology: study protocol for a double-center, randomized, patient- and assessor-blinded, sham-controlled, parallel, clinical trial

Potential New Approaches for Diagnosis of Alzheimer's Disease and Related Dementias

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