Early Detection of Congenital Cardiovascular Malformations in Infancy

Congenital heart defects: The patients who die

“…Nearly all such deaths were caused by severe extracardiac malformations or syndromes, often associated with preterm birth, and causing death within hours or a few days after birth. This is in accordance with other studies 11, and underlines that such conditions are signals for evaluation of heart disease.…”

Prevalence and Clinical Significance of Cardiac Murmurs in Neonates

“…(8) Until preventive measures become available, reduction of infant mortality due to congenital cardiovascular malformations will continue to depend on early recognition of symptoms and signs of serious heart disease in infants and on effective community-wide use of specialised cardiac services. (9) This prospective study is designed to determine the prevalence and clinical significance of murmurs heard during routine examination of neonates and the contribution of the neonatal examination to detection of congenital heart disease in neonates.…”

Tetralogy of Fallot: epidemiology meets real-world management: lessons from the Baltimore-Washington Infant Study

“…2 Three findings in this population of infants with Tetralogy of Fallot and common arterial trunk emerged from the data, and certainly impacted clinical management in an era of evolution to early primary repair: these infants were much more likely to be low birth weight, premature and small for gestational age than the cohort of infants with other forms of congenital heart disease, and certainly when compared with a population-based control group. 5 Moreover, the population of infants with Tetralogy of Fallot and common arterial trunk was more likely to have associated chromosomal and/or non-cardiac organ malformations, impacting their care.…”