Early detection of Alzheimer's disease using PiB and FDG PET

Cohen, Ann D.; Klunk, William E.

doi:10.1016/j.nbd.2014.05.001

Cited by 177 publications

(127 citation statements)

References 94 publications

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“…13,147 Amyloid and tau imaging with positron emission tomography could also be helpful to diagnose comorbidity with AD in the patients with mixed disease, 145 with the caveat that amyloid deposits can also be present in cognitively normal individuals. 146 Biochemical CSF studies provide the third axis of diagnosis; elevated albumin ratio indicates that the BBB is compromised, which is more likely to occur in SVD than in AD. Furthermore, CSF shows changes in proteins associated with AD, including A 42 and pTau.…”

Section: An Approach To Targeted Treatment Trialsmentioning

confidence: 99%

Consensus statement for diagnosis of subcortical small vessel disease

Rosenberg

Wallin

Wardlaw

et al. 2015

J Cereb Blood Flow Metab

181

132

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Vascular cognitive impairment (VCI) is the diagnostic term used to describe a heterogeneous group of sporadic and hereditary diseases of the large and small blood vessels. Subcortical small vessel disease (SVD) leads to lacunar infarcts and progressive damage to the white matter. Patients with progressive damage to the white matter, referred to as Binswanger's disease (BD), constitute a spectrum from pure vascular disease to a mixture with neurodegenerative changes. Binswanger's disease patients are a relatively homogeneous subgroup with hypoxic hypoperfusion, lacunar infarcts, and inflammation that act synergistically to disrupt the blood-brain barrier (BBB) and break down myelin. Identification of this subgroup can be facilitated by multimodal disease markers obtained from clinical, cerebrospinal fluid, neuropsychological, and imaging studies. This consensus statement identifies a potential set of biomarkers based on underlying pathologic changes that could facilitate diagnosis and aid patient selection for future collaborative treatment trials.

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Section: An Approach To Targeted Treatment Trialsmentioning

confidence: 99%

Consensus statement for diagnosis of subcortical small vessel disease

Rosenberg

Wallin

Wardlaw

et al. 2015

J Cereb Blood Flow Metab

181

132

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show abstract

“…According to Sixsmith and Gutman [1] games are a part of technology that developed for elderly people to allow them to experience enjoyable moments in their life. In addition, Cohen and Klunk [39] said leisure technology such as playing games is a relaxing method for elderly people to improve their cognitive thinking and memory to prevent Mild Cognitive Impairment (MCI), which leads to Alzheimer's disease at a later stage. The outcome of this study also showed that elderly people enjoyed the games with less difficulty such as eye fatigue and body aches.…”

Section: ) Sectionmentioning

confidence: 99%

Leisure Technology for the Elderly: A Survey, User Acceptance Testing and Conceptual Design

Theng¹,

Sagadevan²,

Malim³

2017

ijacsa

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Abstract-The Alzheimer's disease damages neuronal and synaptic system due to the high level of amyloid beta in the brain. It is the common cause of dementia which is more common to afflict the elderly where they will gradually loss their memory and communication skills as well as deterioration of thinking and reasoning ability. Hence, it is crucial for elderly people to monitor their cognitive performance consistently and continuously to detect the Alzheimer's symptoms, such as dementia or Mild Cognitive Impairment. There are many technologies that have been established in healthcare for its detection; however, such technologies, mostly medical treatments could not be self-catered by elderly on daily basis and in fact the use of this technology incurs cost each time. Therefore, this study looks at an alternative technology called leisure technology that allows access to the elderly every day at home in an enjoyable and relaxing manner. The aim of this study is to study applications of leisure activities that could stimulate brain cognitive function to be turned to a leisure technology application. Prior to proposing the conceptual design of this application, a user acceptance study of leisure technology among elderly people has been conducted. This study involves interviews and survey through distribution of questionnaires. The survey results shows that 90% of the participants stated that there was an improvement in cognitive abilities after using leisure technology and 98.4% of the participants stated that they could adapt to leisure technology. On the other hand, the outcomes from the interview show that they agreed that different types of leisure technology provide heterogeneous benefits, which can improve their cognitive abilities. Finally, this study proposes a conceptual design for leisure technology application that elderly people can adapt to.

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“…C 11 -Pittsburg compound B-PET: PiB-PET) show that reduced neuronal glucose metabolism and increased levels of neocortical Aβ accumulation are features that occur early in the disease (see review ref. 15). A small number of cohort studies have investigated the relationship between these imaging markers of AD and T2D.…”

Section: Growing Evidence Supports the Hypothesis That Type 2 Diabetementioning

confidence: 99%

[P4–134]: Insulin Resistance Is Associated With Reductions in Specific Cognitive Domains and Increases in CSF Tau in Cognitively Normal Adults

Laws

Gaskin

Woodfield

et al. 2017

Alzheimer's & Dementia

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Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models demonstratesEpidemiological studies indicate that Type 2 diabetes (T2D) is associated with an increased risk of dementia [1][2][3][4][5] . Clinical studies using cross-sectional designs support this association by showing that cognition is worse in patients with T2D as compared to matched controls without T2D 6,7 . Furthermore, studies of structural magnetic resonance imaging (MRI) show that in T2D cognitive impairment is associated with greater levels of vascular

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Early detection of Alzheimer's disease using PiB and FDG PET

Cited by 177 publications

References 94 publications

Consensus statement for diagnosis of subcortical small vessel disease

Consensus statement for diagnosis of subcortical small vessel disease

Leisure Technology for the Elderly: A Survey, User Acceptance Testing and Conceptual Design

[P4–134]: Insulin Resistance Is Associated With Reductions in Specific Cognitive Domains and Increases in CSF Tau in Cognitively Normal Adults

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