Early detection of acute kidney injury by serum cystatin C in critically ill children

Abstract

Our results identify that the sensitivity of serum CysC for detecting AKI is higher than that of serum Cr in a heterogeneous pediatric intensive care unit (PICU) population.

Prediction of urine volume soon after birth using serum cystatin C

“…In contrast to Cr, CysC is not affected by age, diet, or exercise, and since its concentration in the blood is dependent on the glomerular filtration rate, it has been reported to be a useful diagnostic biomarker in patients with AKI [18][19][20] except children, in whom the utility of CysC was limited and not considered to surpass that of Cr [21,22]. Recent studies, however, have shown that S-CysC is more useful biomarker for renal function than S-Cr even in children including neonates [23][24][25]. Furthermore, unlike Cr, CysC does not cross the placenta; therefore, the CysC levels may reflect renal function of the neonates even at the first day of life [26,27] though only few studies have examined S-CysC levels in this period [5][6][7].…”

Serum Cystatin C as an Early Indicator for Acute Kidney Injury in Critically Ill Children in Pediatric Intensive Care Units

“…Also, Volpon et al [17] stated that in critically ill children, serum Cystatin C is an early and accurate diagnostic marker of AKI. Another study has reported that the sensitivity and specificity of serum cystatin C for diagnosing AKI are 73.9 % and 78.9, respectively, using 0.6 mg/l as the cutoff value (6) . Similarly, a study conducted by Lagos-Arevaldo et al [18] on pediatric patients admitted to a PICU has reported that serum cystatin C has more diagnostic accuracy than serum creatinine and a greater predictive value for clinical outcomes.…”

“…[2] Recently, cystatin C has been shown to be a sensitive marker for early AKI diagnosis in children admitted to a pediatric intensive care unit (PICU) [6] .…”

Цистатин С І Хронічна Хвороба Нирок У Дітей

“…Сироватковий цистатин С дозво-ляє передбачити розвиток ГУН на 1-2 доби рані-ше, ніж сироватковий креатинін. Він є чутливим предиктором ГУН у дітей в критичному стані і в разі лікування аміноглікозидами [4,25], прогнос-тичним біомаркером для ГУН після кардіохірургіч-них втручань [23].…”