Early Clinical and Surgical Results of Biliopancreatic Diversion

Luis, Daniel Antonio de; Pacheco, David; Izaola, Olatz; Romero, Alejandro; Marcos, José Luis; Pelaz, J; Barrera, Andrea; Cabezas, G; Terroba, M. C.; Cuéllar, L; Anta, A

doi:10.1381/0960892054222740

Cited by 30 publications

(14 citation statements)

References 11 publications

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“…However, nutrient deficiencies can occur [26] due to many mechanisms, for example the type of surgery [27][28] . Proper monitoring of nutritional status and additional supplementation, as needed, can aid in preventing severe clinical and biochemical deficiencies.…”

Section: Discussionmentioning

confidence: 99%

Clinical Results and Nutritional Consequences of Biliopancreatic Diversion: Three Years of Follow-Up

et al. 2008

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Background: Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The aim of our work was to describe clinical results and nutritional complications in morbidly obese patients with biliopancreatic diversion. Methods: We have analyzed a consecutive series of 64 patients who have been followed up for 3 years after undergoing open biliopancreatic diversion by the Scopinaro technique. Results: Initial excess weight loss was 29.3% at 6 months and 61.5% at 3 years. A significant improvement of body mass index, weight, waist circumference, fat mass, glucose level, total cholesterol, uric acid and triglycerides levels was detected. Ferritin, vitamin A, vitamin D, vitamin B₁₂, zinc and copper levels showed a low percentage of deficiency at basal time, but during the follow-up, the percentage of deficiency increased. Vitamin E and K did not show basal deficiency. However, after surgery, a moderate deficiency of both vitamins was detected (vitamin E 7.1% and vitamin K 8.3%). Folic acid deficiency was observed in 54.3% of the subjects at basal time, but decreased during the study. Conclusion: Biliopancreatic diversion is an effective method of sustainable weight loss. However, micronutrient deficiencies can occur.

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Section: Discussionmentioning

confidence: 99%

Clinical Results and Nutritional Consequences of Biliopancreatic Diversion: Three Years of Follow-Up

et al. 2008

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“…Follow-up visits were carried out at intervals (3, 9, 12 and 18 months). We analyzed this consecutive series of patients who underwent open biliopancreatic diversion (BPD) by the Scopinaro technique [13]. The BPD consisted of an average 200-cm alimentary limb and 80-cm common limb.…”

Section: Methodsmentioning

confidence: 99%

Role of the rs6923761 Gene Variant in Glucagon-Like Peptide 1 Receptor Gene on Cardiovascular Risk Factors and Weight Loss after Biliopancreatic Diversion Surgery

Luis¹,

Pacheco²,

Aller³

et al. 2014

Ann Nutr Metab

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Background: Studies of the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) have been directed at identifying polymorphisms in the GLP-1R gene that may be a contributing factor in the pathogenesis of obesity. Objective: We decided to investigate the role of the rs6923761 GLP-1R polymorphism on outcomes after biliopancreatic diversion. Design: A sample of 137 morbidly obese patients was operated. Weight, blood pressure, basal glucose and lipid profile were measured at the basal visit and at each following visit (basal, 3, 9, 12 and 18 months). Results: Body mass index, weight and waist circumference were lower in non-A allele carriers than A allele carriers 12 and 18 months after surgery. The initial weight percent loss at 12 months (45.6 vs. 39.8%; p < 0.05) or 18 months (49.6 vs. 41.3%; p < 0.05) was higher in patients with GG genotype than A allele carriers. Conclusion: Our study showed a higher weight loss 12 and 18 months after bariatric surgery in GG variant than A allele carriers. The biochemical parameters and cardiovascular comorbidity rates improved similarly in both genotypes.

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“…Biliopancreatic diversion (BPD) [2] is a mixed operation, having anatomically both restrictive and malabsorptive components, that has shown good results regarding weight loss. This operation has been associated with a 70% mean excess weight loss maintained for 15 years.…”

Section: Introductionmentioning

confidence: 99%

Basal GLP-1 Levels in Morbidly Obese Patients following Biliopancreatic Diversion Surgery

Luis¹,

Pacheco²,

Conde³

et al. 2012

Ann Nutr Metab

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Background: Previous studies addressing the changes of glucagon-like peptide-1 (GLP-1) concentrations in morbidly obese patients after bariatric surgery have demonstrated conflicting results. The aim of the present study was to investigate the changes in serum GLP-1 levels 9 months after biliopancreatic diversion in morbidly obese patients without diabetes mellitus. Methods: A sample of 40 morbidly obese patients without diabetes mellitus was enrolled. Biochemical and anthropometrical evaluations were conducted at basal and 9 months after surgery. Results: The mean patient age was 46.6 ± 13.1 years, and the mean preoperative body mass index (BMI) was 47.1 ± 18.1. A significant decrease in BMI, weight, waist circumference, fat mass, glucose, LDL cholesterol, total cholesterol, and triglyceride levels was observed after 9 months. Serum basal GLP-1 levels did not change after surgery (0.65 ± 0.18 ng/ml vs. 0.66 ± 0.17 ng/ml; n.s.). Postsurgical correlation analysis showed a negative association between basal GLP-1 and HDL cholesterol (r = –0.57; p < 0.01). Conclusions: Fasting GLP-1 concentrations did not change after massive weight loss with biliopancreatic diversion in morbidly obese patients without diabetes mellitus.

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Early Clinical and Surgical Results of Biliopancreatic Diversion

Abstract: BPD showed early effectiveness in weight loss and co-morbidity improvement. Calorie, protein, oligoelement and vitamin dietary intakes were below recommendations, so that strict multidisciplinary follow-up and supplementation to prevent or treat nutritional deficiencies are mandatory.

Cited by 30 publications

References 11 publications

Clinical Results and Nutritional Consequences of Biliopancreatic Diversion: Three Years of Follow-Up

Clinical Results and Nutritional Consequences of Biliopancreatic Diversion: Three Years of Follow-Up

Role of the rs6923761 Gene Variant in Glucagon-Like Peptide 1 Receptor Gene on Cardiovascular Risk Factors and Weight Loss after Biliopancreatic Diversion Surgery

Basal GLP-1 Levels in Morbidly Obese Patients following Biliopancreatic Diversion Surgery

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