Early aspects of the intrarenal distribution of mercury after the intravenous administration of mercuric chloride

Disposition of inorganic mercury in pregnant rats and their offspring

“…In other words, the renal accumulation of Hg 2+ was rapid and the elimination of Hg 2+ from the kidney was minimal. The rapid accumulation of Hg 2+ in the kidney corresponds with previous findings indicating that 40% of the administered dose of Hg 2+ is present in the kidney within 3 h of exposure (Zalups, 1993; Zalups and Minor, 1995). The lack of elimination is likely due to complex intracellular binding reactions between mercuric ions and intracellular proteins and non-protein thiols, which consequently restricts movement of mercuric ions out of proximal tubular cells (Barbier et al, 2005; Zalups, 2000).…”

Disposition of inorganic mercury in pregnant rats and their offspring

“…In other words, the renal accumulation of Hg 2+ was rapid and the elimination of Hg 2+ from the kidney was minimal. The rapid accumulation of Hg 2+ in the kidney corresponds with previous findings indicating that 40% of the administered dose of Hg 2+ is present in the kidney within 3 h of exposure (Zalups, 1993; Zalups and Minor, 1995). The lack of elimination is likely due to complex intracellular binding reactions between mercuric ions and intracellular proteins and non-protein thiols, which consequently restricts movement of mercuric ions out of proximal tubular cells (Barbier et al, 2005; Zalups, 2000).…”

Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride

“…1,42 The kidneys are the primary organs that accumulate inorganic mercury, and the presence of this metal within the tubular cell may be seen within a few hours after exposure. 8 In the present study, lactating and nonlactating rats showed an increase in renal Hg levels, and as a consequence, an increase in urine Hg levels after exposure to HgCl 2 . The previous exposure to ZnCl 2 increased 92% and 15% kidney Hg accumulation in lactating and nonlactating rats, respectively, when compared with Sal-Hg group.…”

“…HgCl 2 has been recognized as a nephrotoxic agent that causes several alterations in renal functions . The kidneys are the primary organs that accumulate inorganic mercury, and the presence of this metal within the tubular cell may be seen within a few hours after exposure . In the present study, lactating and nonlactating rats showed an increase in renal Hg levels, and as a consequence, an increase in urine Hg levels after exposure to HgCl 2 .…”

Relationships between the Renal Handling of DMPS and DMSA and the Renal Handling of Mercury

“…Interestingly, though, mercuric ions bound to albumin and other plasma proteins appear to be bound to these proteins for relatively short periods. This idea is supported by findings showing that the plasma burden of Hg decreases rapidly after exposure, while there is a concurrent rapid rate of nonendocytotic uptake of mercuric ions in the epithelial cells of the kidneys and liver. , …”

Disposition of inorganic mercury in pregnant rats and their offspring

“…In other words, the renal accumulation of Hg 2+ was rapid and the elimination of Hg 2+ from the kidney was minimal. The rapid accumulation of Hg 2+ in the kidney corresponds with previous findings indicating that 40% of the administered dose of Hg 2+ is present in the kidney within 3 h of exposure (Zalups, 1993; Zalups and Minor, 1995). The lack of elimination is likely due to complex intracellular binding reactions between mercuric ions and intracellular proteins and non-protein thiols, which consequently restricts movement of mercuric ions out of proximal tubular cells (Barbier et al, 2005; Zalups, 2000).…”

Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride

“…1,42 The kidneys are the primary organs that accumulate inorganic mercury, and the presence of this metal within the tubular cell may be seen within a few hours after exposure. 8 In the present study, lactating and nonlactating rats showed an increase in renal Hg levels, and as a consequence, an increase in urine Hg levels after exposure to HgCl 2 . The previous exposure to ZnCl 2 increased 92% and 15% kidney Hg accumulation in lactating and nonlactating rats, respectively, when compared with Sal-Hg group.…”

“…HgCl 2 has been recognized as a nephrotoxic agent that causes several alterations in renal functions . The kidneys are the primary organs that accumulate inorganic mercury, and the presence of this metal within the tubular cell may be seen within a few hours after exposure . In the present study, lactating and nonlactating rats showed an increase in renal Hg levels, and as a consequence, an increase in urine Hg levels after exposure to HgCl 2 .…”

Relationships between the Renal Handling of DMPS and DMSA and the Renal Handling of Mercury

“…Interestingly, though, mercuric ions bound to albumin and other plasma proteins appear to be bound to these proteins for relatively short periods. This idea is supported by findings showing that the plasma burden of Hg decreases rapidly after exposure, while there is a concurrent rapid rate of nonendocytotic uptake of mercuric ions in the epithelial cells of the kidneys and liver. , …”

Disposition of inorganic mercury in pregnant rats and their offspring

“…In other words, the renal accumulation of Hg 2+ was rapid and the elimination of Hg 2+ from the kidney was minimal. The rapid accumulation of Hg 2+ in the kidney corresponds with previous findings indicating that 40% of the administered dose of Hg 2+ is present in the kidney within 3 h of exposure (Zalups, 1993; Zalups and Minor, 1995). The lack of elimination is likely due to complex intracellular binding reactions between mercuric ions and intracellular proteins and non-protein thiols, which consequently restricts movement of mercuric ions out of proximal tubular cells (Barbier et al, 2005; Zalups, 2000).…”

Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride

“…1,42 The kidneys are the primary organs that accumulate inorganic mercury, and the presence of this metal within the tubular cell may be seen within a few hours after exposure. 8 In the present study, lactating and nonlactating rats showed an increase in renal Hg levels, and as a consequence, an increase in urine Hg levels after exposure to HgCl 2 . The previous exposure to ZnCl 2 increased 92% and 15% kidney Hg accumulation in lactating and nonlactating rats, respectively, when compared with Sal-Hg group.…”

“…HgCl 2 has been recognized as a nephrotoxic agent that causes several alterations in renal functions . The kidneys are the primary organs that accumulate inorganic mercury, and the presence of this metal within the tubular cell may be seen within a few hours after exposure . In the present study, lactating and nonlactating rats showed an increase in renal Hg levels, and as a consequence, an increase in urine Hg levels after exposure to HgCl 2 .…”

Relationships between the Renal Handling of DMPS and DMSA and the Renal Handling of Mercury

“…Interestingly, though, mercuric ions bound to albumin and other plasma proteins appear to be bound to these proteins for relatively short periods. This idea is supported by findings showing that the plasma burden of Hg decreases rapidly after exposure, while there is a concurrent rapid rate of nonendocytotic uptake of mercuric ions in the epithelial cells of the kidneys and liver. , …”