2016
DOI: 10.1016/j.pharep.2016.06.003
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Abstract: This study revealed that aripiprazole, olanzapine and risperidone affected 5-HT2AR, 5-HT2CR, 5-HTT, D1R and D2R bindings differently in the brains of juvenile male and female rats.

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Cited by 16 publications
(33 citation statements)
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“…Whilst similar investigations into the adult animal model has found no alterations to DA D 1 receptor density levels in the PFC, CPu, NAc and hippocampus following long-term olanzapine and risperidone drug treatment [57], similar decreases in DA D 1 receptor levels have been uncovered in previous investigations in young animals. Studies investigating the immediate effects of juvenile APD treatment following a short-term treatment period [38,40], and long-lasting effects following long-term treatment period [18,37], has found that both olanzapine and clozapine resulted in a decreased D 1 receptor density level in the PFC and NAc of young male rats.…”
Section: Discussionmentioning
confidence: 99%
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“…Whilst similar investigations into the adult animal model has found no alterations to DA D 1 receptor density levels in the PFC, CPu, NAc and hippocampus following long-term olanzapine and risperidone drug treatment [57], similar decreases in DA D 1 receptor levels have been uncovered in previous investigations in young animals. Studies investigating the immediate effects of juvenile APD treatment following a short-term treatment period [38,40], and long-lasting effects following long-term treatment period [18,37], has found that both olanzapine and clozapine resulted in a decreased D 1 receptor density level in the PFC and NAc of young male rats.…”
Section: Discussionmentioning
confidence: 99%
“…Previously, several animal studies investigating the effects of early APD use on the developing brain, including previous investigations completed in our laboratory, has found that early treatment of up to 4 weeks can result in various significant alterations to both behavioural attributes [31], and numerous NT systems, including the DAergic NT system [18,36,37,38,39,40]. Whilst numerous investigations have found that early treatment with various APDs in juvenile rats has resulted in various short-term alterations immediately after treatment [36,38,40], studies into potential long-term alterations are fewer in number [18,37].…”
Section: Introductionmentioning
confidence: 99%
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“…Recent preclinical studies of adolescent APD treatment have attempted to achieve a more clinically comparable pharmacokinetic profiles through the use of oral administration via cookie dough (three times a day) (De Santis et al 2016;Lian et al 2015;Lian et al 2016) or drinking water Vinish et al 2013;Xu et al 2015). Yet, only in one of these studies, plasma concentration of APD achieved was examined .…”
Section: Limitations and Future Directionsmentioning
confidence: 99%
“…While still limited in number, existing preclinical studies have attempted to identify short-term behavioural and neurochemical effects of adolescent APD treatment [for example, (Choi et al 2009;Lian et al 2016;Moran-Gates et al 2007;Wiley 2008;Wiley and Evans 2008)]. A few preclinical studies over the past five years have also started to examine long-term neurobiological consequences of adolescent treatment with atypical APDs (De Santis et al 2016;Milstein et al 2013;Qiao et al 2013;Vinish et al 2013).…”
Section: Introductionmentioning
confidence: 99%