Early and subtle abnormalities of left ventricular function in clinically stable coronary artery disease patients with normal ejection fraction

Bolognesi, R; Tsialtas, Dimitri; Zeppellini, R; Barilli, Angela Luciana; Cucchini, F; Manca, C

doi:10.1016/j.cardfail.2003.10.010

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Regarding This finding was in agreement with the report of [19], [20] authors who found that , Measurement of myocardial velocities by tissue Doppler imaging (TDI) is a promising approach for quantitative assessment of longitudinal systolic ventricular performance in adults.…”

Section: Discussionsupporting

confidence: 92%

Assessment of left ventricular systolic function in children with iron deficiency anemia by two-dimentional echocardiography and tissue Doppler in Beni- Suef university hospital

Mabrouk

Morgan

Ahmed

et al. 2022

Egyptian Journal of Medical Research

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Cardiac structure and function in iron deficiency anemia are mainly affected by two competing factors: iron deficiency and increased cardiac output (CO). Anaemia and iron deficiency (ID) are common causes of heart failure, both separately and in combination.The goal of this study is to assess the systolic function of left ventricle in ( IDA )using tissue doppler in pediatrics . Sixty (60) children grouped into two groups,one with IDA and another control group. All candidates were suspected to history taking, full clinical examination ,complete blood count ,iron profile and echocardiographic examination. There was significant difference between cases and controls regarding peak systolic velocity across mitral annulus (SM) using tissue doppler imaging . There was no significant difference in left ventricle (LV) dimentions between cases and controls, The mean value of LVESV in case group was 2.0 ± .28 cm while it was 2.1 ± .3 cm in control P value was (.64) . There was no correlation between HB level or ferritin level and SM or EFThe study revealed preserved LV systolic functions as detected by conventional echocardiography however tissue Doppler imaging technique had shown latent LV systolic dysfunction Further follow up is needed for cases to assess reversability of finding .

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Section: Discussionsupporting

confidence: 92%

Assessment of left ventricular systolic function in children with iron deficiency anemia by two-dimentional echocardiography and tissue Doppler in Beni- Suef university hospital

Mabrouk

Morgan

Ahmed

et al. 2022

Egyptian Journal of Medical Research

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“…Most studies that have used dP/dt max -related parameters had similar HRs between the animals (3,15,18), which makes the Treppe effect less likely to play a role (37). However, not all animals have equivalent HRs, which can also fluctuate with some of the treatment regimens.…”

Section: Discussionmentioning

confidence: 93%

Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dt_max complementary or redundant?

Ishikawa

Chemaly

Tilemann

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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Among the various cardiac contractility parameters, left ventricular (LV) ejection fraction (EF) and maximum dP/dt (dP/dt(max)) are the simplest and most used. However, these parameters are often reported together, and it is not clear if they are complementary or redundant. We sought to compare the discriminative value of EF and dP/dt(max) in assessing systolic dysfunction after myocardial infarction (MI) in swine. A total of 220 measurements were obtained. All measurements included LV volumes and EF analysis by left ventriculography, invasive ventricular pressure tracings, and echocardiography. Baseline measurements were performed in 132 pigs, and 88 measurements were obtained at different time points after MI creation. Receiver operator characteristic (ROC) curves to distinguish the presence or absence of an MI revealed a good predictive value for EF [area under the curve (AUC): 0.998] but not by dP/dt(max) (AUC: 0.69, P < 0.001 vs. EF). Dividing dP/dt(max) by LV end-diastolic pressure and heart rate (HR) significantly increased the AUC to 0.87 (P < 0.001 vs. dP/dt(max) and P < 0.001 vs. EF). In naïve pigs, the coefficient of variation of dP/dt(max) was twice than that of EF (22.5% vs. 9.5%, respectively). Furthermore, in n = 19 pigs, dP/dt(max) increased after MI. However, echocardiographic strain analysis of 23 pigs with EF ranging only from 36% to 40% after MI revealed significant correlations between dP/dt(max) and strain parameters in the noninfarcted area (circumferential strain: r = 0.42, P = 0.05; radial strain: r = 0.71, P < 0.001). In conclusion, EF is a more accurate measure of systolic dysfunction than dP/dt(max) in a swine model of MI. Despite the variability of dP/dt(max) both in naïve pigs and after MI, it may sensitively reflect the small changes of myocardial contractility.

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“…The linearity between dP/dtmax and EDV reported in the literature suggest this index might be a more reliable to assess the contractility state in vivo [ 23 , 26 ]. Of note, most of the studies that have used dP/dt max as a contractility index had similar heart rate between the groups, which makes the Treppe effect less likely to occur [ 27 , 28 ]. Ishikawa and colleagues have demonstrated that the ejection fraction is more sensitive at detecting systolic dysfunction over the dP/dt max in an elegant model of myocardial infarction in swine.…”

Section: Discussionmentioning

confidence: 99%

Diacerein Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction

et al. 2015

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BackgroundThe inflammatory response has been implicated in the pathogenesis of left ventricular (LV) remodeling after myocardial infarction (MI). An anthraquinone compound with anti-inflammatory properties, diacerein inhibits the synthesis and activity of pro-inflammatory cytokines, such as tumor necrosis factor and interleukins 1 and 6. The purpose of this study was to investigate the effects of diacerein on ventricular remodeling in vivo.Methods and ResultsLigation of the left anterior descending artery was used to induce MI in an experimental rat model. Rats were divided into two groups: a control group that received saline solution (n = 16) and a group that received diacerein (80 mg/kg) daily (n = 10). After 4 weeks, the LV volume, cellular signaling, caspase 3 activity, and nuclear factor kappa B (NF-κB) transcription were compared between the two groups. After 4 weeks, end-diastolic and end-systolic LV volumes were reduced in the treatment group compared to the control group (p < .01 and p < .01, respectively). Compared to control rats, diacerein-treated rats exhibited less fibrosis in the LV (14.65%± 7.27% vs. 22.57%± 8.94%; p < .01), lower levels of caspase-3 activity, and lower levels of NF-κB p65 transcription.ConclusionsTreatment with diacerein once a day for 4 weeks after MI improved ventricular remodeling by promoting lower end-systolic and end-diastolic LV volumes. Diacerein also reduced fibrosis in the LV. These effects might be associated with partial blockage of the NF-κB pathway.

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Early and subtle abnormalities of left ventricular function in clinically stable coronary artery disease patients with normal ejection fraction

Cited by 5 publications

References 18 publications

Assessment of left ventricular systolic function in children with iron deficiency anemia by two-dimentional echocardiography and tissue Doppler in Beni- Suef university hospital

Assessment of left ventricular systolic function in children with iron deficiency anemia by two-dimentional echocardiography and tissue Doppler in Beni- Suef university hospital

Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dt_max complementary or redundant?

Diacerein Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction

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Early and subtle abnormalities of left ventricular function in clinically stable coronary artery disease patients with normal ejection fraction

Cited by 5 publications

References 18 publications

Assessment of left ventricular systolic function in children with iron deficiency anemia by two-dimentional echocardiography and tissue Doppler in Beni- Suef university hospital

Assessment of left ventricular systolic function in children with iron deficiency anemia by two-dimentional echocardiography and tissue Doppler in Beni- Suef university hospital

Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dtmax complementary or redundant?

Diacerein Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction

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Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dt_max complementary or redundant?