Early Alzheimer's Disease

Revised Criteria for Mild Cognitive Impairment May Compromise the Diagnosis of Alzheimer Disease Dementia

“…63 The use of informant report to capture the intraindividual cognitive and functional decline that is the hallmark of symptomatic AD both minimizes this heterogeneity and enables the accurate identification of the subset of MCI that is caused by AD. 23,64–67 The clinical diagnosis of symptomatic AD with this method, even in individuals who meet MCI criteria, is supported by autopsy confirmation of AD neuropathology at rates (92%) comparable to those found for AD dementia. 68 …”

Revised Criteria for Mild Cognitive Impairment May Compromise the Diagnosis of Alzheimer Disease Dementia

“…63 The use of informant report to capture the intraindividual cognitive and functional decline that is the hallmark of symptomatic AD both minimizes this heterogeneity and enables the accurate identification of the subset of MCI that is caused by AD. 23,64–67 The clinical diagnosis of symptomatic AD with this method, even in individuals who meet MCI criteria, is supported by autopsy confirmation of AD neuropathology at rates (92%) comparable to those found for AD dementia. 68 …”

Outcomes after diagnosis of mild cognitive impairment in a large autopsy series

“…Participants with a CDR global score of 0.5 often have AD pathology at autopsy regardless of subsequent CDR global scores of 0 [22]. Back transitions (e.g., a diagnosis of MCI followed by subsequent diagnosis of intact cognition) may be explained by many factors including inter-clinician differences in application of diagnostic criteria, within-patient variability due to medical illness, polypharmacy, psychosocial factors, and/or resistance to cognitive decline due to cognitive reserve [7,23].…”

Keep Up the Pace: Declines in Simple Repetitive Timing Differentiate Healthy Aging from the Earliest Stages of Alzheimer's Disease

“…The remaining 216 older adults were recruited from the Washington University Alzheimer’s Disease Research Center (ADRC) and were screened for depression, untreated hypertension, reversible dementias, and other disorders associated with cognitive impairment. Presence and severity of dementia was assessed using the Washington University Clinical Dementia Rating (CDR) scale (Morris, 1993; Morris & Fulling, 1988). CDR scale values and their matching dementia status are: 0 = no dementia, .5 = very mild dementia, 1 = mild dementia, 2 = moderate dementia, and 3 = severe dementia.…”

Revised Criteria for Mild Cognitive Impairment May Compromise the Diagnosis of Alzheimer Disease Dementia

“…63 The use of informant report to capture the intraindividual cognitive and functional decline that is the hallmark of symptomatic AD both minimizes this heterogeneity and enables the accurate identification of the subset of MCI that is caused by AD. 23,64–67 The clinical diagnosis of symptomatic AD with this method, even in individuals who meet MCI criteria, is supported by autopsy confirmation of AD neuropathology at rates (92%) comparable to those found for AD dementia. 68 …”

Outcomes after diagnosis of mild cognitive impairment in a large autopsy series

“…Participants with a CDR global score of 0.5 often have AD pathology at autopsy regardless of subsequent CDR global scores of 0 [22]. Back transitions (e.g., a diagnosis of MCI followed by subsequent diagnosis of intact cognition) may be explained by many factors including inter-clinician differences in application of diagnostic criteria, within-patient variability due to medical illness, polypharmacy, psychosocial factors, and/or resistance to cognitive decline due to cognitive reserve [7,23].…”

Keep Up the Pace: Declines in Simple Repetitive Timing Differentiate Healthy Aging from the Earliest Stages of Alzheimer's Disease

“…The remaining 216 older adults were recruited from the Washington University Alzheimer’s Disease Research Center (ADRC) and were screened for depression, untreated hypertension, reversible dementias, and other disorders associated with cognitive impairment. Presence and severity of dementia was assessed using the Washington University Clinical Dementia Rating (CDR) scale (Morris, 1993; Morris & Fulling, 1988). CDR scale values and their matching dementia status are: 0 = no dementia, .5 = very mild dementia, 1 = mild dementia, 2 = moderate dementia, and 3 = severe dementia.…”

Revised Criteria for Mild Cognitive Impairment May Compromise the Diagnosis of Alzheimer Disease Dementia

“…63 The use of informant report to capture the intraindividual cognitive and functional decline that is the hallmark of symptomatic AD both minimizes this heterogeneity and enables the accurate identification of the subset of MCI that is caused by AD. 23,64–67 The clinical diagnosis of symptomatic AD with this method, even in individuals who meet MCI criteria, is supported by autopsy confirmation of AD neuropathology at rates (92%) comparable to those found for AD dementia. 68 …”

Outcomes after diagnosis of mild cognitive impairment in a large autopsy series

“…Participants with a CDR global score of 0.5 often have AD pathology at autopsy regardless of subsequent CDR global scores of 0 [22]. Back transitions (e.g., a diagnosis of MCI followed by subsequent diagnosis of intact cognition) may be explained by many factors including inter-clinician differences in application of diagnostic criteria, within-patient variability due to medical illness, polypharmacy, psychosocial factors, and/or resistance to cognitive decline due to cognitive reserve [7,23].…”

Keep Up the Pace: Declines in Simple Repetitive Timing Differentiate Healthy Aging from the Earliest Stages of Alzheimer's Disease

“…The remaining 216 older adults were recruited from the Washington University Alzheimer’s Disease Research Center (ADRC) and were screened for depression, untreated hypertension, reversible dementias, and other disorders associated with cognitive impairment. Presence and severity of dementia was assessed using the Washington University Clinical Dementia Rating (CDR) scale (Morris, 1993; Morris & Fulling, 1988). CDR scale values and their matching dementia status are: 0 = no dementia, .5 = very mild dementia, 1 = mild dementia, 2 = moderate dementia, and 3 = severe dementia.…”