Abstract:Aging is associated with progressive decline in cell function and with increased
damage to macromolecular components. DNA damage, in the form of double-strand breaks
(DSBs), increases with age and in turn, contributes to the aging process and
age-related diseases. DNA strand breaks triggers a set of highly orchestrated
signaling events known as the DNA damage response (DDR), which coordinates DNA
repair. However, whether the accumulation of DNA damage with age is a result of
decreased repair capacity, remains …
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