volume 8, issue 11, P3131-3146 2016
DOI: 10.18632/aging.101120
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Avital Guedj, Anat Geiger-Maor, Hadar Benyamini, Yaval Nevo, Sharona Elgavish, Eithan Galun, Hagai Amsalem, Jacob Rachmilewitz

Abstract: Aging is associated with progressive decline in cell function and with increased damage to macromolecular components. DNA damage, in the form of double-strand breaks (DSBs), increases with age and in turn, contributes to the aging process and age-related diseases. DNA strand breaks triggers a set of highly orchestrated signaling events known as the DNA damage response (DDR), which coordinates DNA repair. However, whether the accumulation of DNA damage with age is a result of decreased repair capacity, remains …

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