2000
DOI: 10.1016/s1097-2765(00)00029-0
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Abstract: The retinoblastoma protein (pRB) plays a key role in the control of normal development and proliferation through the regulation of the E2F transcription factors. We generated a mutant mouse model to assess the in vivo role of the predominant E2F family member, E2F4. Remarkably, loss of E2F4 had no detectable effect on either cell cycle arrest or proliferation. However, E2F4 was essential for normal development. E2f4-/- mice died of an increased susceptibility to opportunistic infections that appeared to result… Show more

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Cited by 197 publications
(256 citation statements)
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“…The apparent recovery of the T cell lineage in older mice could be explained by the remarkable capacity of the T cell system to "fill space" through homeostatic expansion (22). Our data are not immediately consistent with the well-authenticated observation that e2f4 Ϫ/Ϫ precursor cells are defective in erythroid differentiation, leading to anemia in surviving E2F4-deficient mice (15,17). To reconcile these observations with our own, we need to consider that possibility that E2F4 acts in HSC self-renewal, in the HSC-to-CLP differentiation process, but also at a later stage in the erythroid lineage.…”
Section: Resultscontrasting
confidence: 67%
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“…The apparent recovery of the T cell lineage in older mice could be explained by the remarkable capacity of the T cell system to "fill space" through homeostatic expansion (22). Our data are not immediately consistent with the well-authenticated observation that e2f4 Ϫ/Ϫ precursor cells are defective in erythroid differentiation, leading to anemia in surviving E2F4-deficient mice (15,17). To reconcile these observations with our own, we need to consider that possibility that E2F4 acts in HSC self-renewal, in the HSC-to-CLP differentiation process, but also at a later stage in the erythroid lineage.…”
Section: Resultscontrasting
confidence: 67%
“…Among these, E2F4 is found at high concentrations in hemopoietic cells (15). Overexpression of E2F4 promotes terminal differentiation of cells in vitro (16), whereas E2F4-deficient animals show reduced neonatal viability, with very few animals surviving to adulthood (15,17). These animals died due to opportunistic infections and anemia, but they were also smaller than either heterozygous or wild-type (WT) littermates (15,17).…”
Section: E2f4 Modulates Differentiation and Gene Expression In Hemopomentioning
confidence: 99%
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“…Four of the eight overexpressed genes, CCND2, E2F3, PCNA, and N-MYC, are involved in cell cycle control and proliferation. CCND2, encoding the regulator subunit of cyclin D2/cyclin dependent kinase complexes, and the transcription factor E2F3 are critical for control of the G1/S transition (Sherr, 1996;Humbert et al, 2000). PCNA plays an essential role in nucleic acid metabolism and is a sensitive indicator of cell proliferation (Kelman, 1997).…”
Section: Discussionmentioning
confidence: 99%