(E)‐Selective Horner—Wadsworth—Emmons Reaction of Aryl Alkyl Ketones with Bis(2,2,2‐trifluoroethyl)phosphonacetic Acid.

Abstract

Carboxylic acid estersCarboxylic acid esters Q 0530 (E)-Selective Horner-Wadsworth-Emmons Reaction of Aryl Alkyl Ketones with Bis(2,2,2-trifluoroethyl)phosphonacetic Acid. -In contrast to the corresponding methyl ester, the phosphonoacetic acid (I) reacts highly (E)-selectively with alkyl aryl ketones (II) utilizing lithium hexamethyldisilazide in DMF. -(SANO*, S.; TAKEMOTO, Y.; NAGAO*, Y.; Tetrahedron Lett. 44 (2003) 49, 8853-8855; Fac. Pharm. Sci., Univ. Tokushima, Sho, Tokushima 770, Japan; Eng.) -Mais 10-095