E-configuration structures of EPA and DHA derived from Euphausia superba and their significant inhibitive effects on growth of human cancer cell lines in vitro

Antarctic Krill (Euphausia superba) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications

“…The anti-cancer activity of krill FFA extract was also confirmed in human osteosarcoma cells, and the inhibition effect of 1.89 μM of FFA extract from krill oil was comparable to 0.5 to 1.0 μM of doxorubicine, which is a commonly used anticancer drug (Su, Tanalgo, Bustos, & Dass, 2018). Zheng et al (2017) EPA and DHA in krill oil, and they found that they exerted much higher inhibitory activities on the growth of some cancer cell lines (U937, K562, SMMC-7721, PC-3, MDA-MB-231, HL60, and MCF-7) than EPA and DHA in some commercial fish oils. Actually, tocopherols and astaxanthin were also reported to have anti-cancer activities (Constantinou, Papas, & Constantinou, 2008;Rao et al, 2013).…”

“…Zheng et al. () separated and identified the E‐configuration structures of EPA and DHA in krill oil, and they found that they exerted much higher inhibitory activities on the growth of some cancer cell lines (U937, K562, SMMC‐7721, PC‐3, MDA‐MB‐231, HL60, and MCF‐7) than EPA and DHA in some commercial fish oils. Actually, tocopherols and astaxanthin were also reported to have anti‐cancer activities (Constantinou, Papas, & Constantinou, ; Rao et al., ).…”

“…Treatment of the cell lines with EPA and DHA obtained from krill oil (10-400 μg/mL in DMEM) acted inhibition effects on cell growth Zheng et al, 2017 In vitro studies on human colon adenocarcinoma cell lines (HCT-15, SW-480 and Caco-2 cells) A daily dose of 300 mg krill oil within a short treatment period (7 to 14 days) resulted in a significant decline in the CRP concentration and alleviation of arthritic symptoms in patients suffering from chronic inflammatory conditions (Deutsch, 2007). Cicero et al (2016) also found that supplementation with 500 mg krill oil twice a day for 4 weeks was able to significantly reduce highsensitivity CRP (hs-CRP) level in plasma from 2.15 to 0.43 mg/L in mildly overweight hypertriglyceridemic subjects.…”

Effect of thermal processing towards lipid oxidation and non‐enzymatic browning reactions of Antarctic krill (Euphausia superba) meal

“…It is a large single species organisms in the world today in terms of biomass and can be used as natural raw material to develop the supplement food such as Antarctic krill protein and Antarctic krill oil. Krill oil (KO) is a significant product derived from Antarctic krill, a major source of biomass, and is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) . KO has also emerged as a vital alternative source of n ‐3 polyunsaturated fatty acids (PUFAs) for human consumption during the last decade .…”

“…KO has also emerged as a vital alternative source of n ‐3 polyunsaturated fatty acids (PUFAs) for human consumption during the last decade . Because the omega‐3 PUFAs in the phospholipids (PLs) of KO can be more effectively absorbed by body tissues than traditional n ‐3 PUFA triglycerides (TAGs) in fish oils, the PLs–EPA/DHA in KO exhibit better bioavailability and oxidative stability, and thus beneficial health effects, such as reducing the risk of coronary heart disease, inflammation, autoimmune disease, hypertension, cancer, diabetes, mental illness and neurological diseases, as well as improving the brain and eye function of infants . Further, KO is proven to have desirable effects on blood lipids, inflammation, and metabolic syndrome .…”