E-Cigarettes Reexamined: Product Toxicity

Pipe, Andrew; Mir, Hassan R.

doi:10.1016/j.cjca.2022.08.001

Cited by 7 publications

(3 citation statements)

References 191 publications

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“…E-Zigaretten sind zu kurz auf dem Markt, um ihre mittel-und langfristigen gesundheitlichen Folgen seriös abschätzen zu können. Belegt ist aber schon heute, dass E-Zigaretten toxisch wirken können [13]. Sie sind schädlich für das Herz-Kreislauf-System [14] und beeinträchtigen die Gesundheit der Atemwege.…”

Section: Zeitpunkt Der Interventionunclassified

Elektronische Zigaretten – Schadensminimierung oder Schadensverlängerung?

Hanewinkel

2023

Pneumologie

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ZusammenfassungDer Beitrag befasst sich mit der Frage, ob Elektronische Zigaretten (E-Zigaretten) den erwiesenen Schaden des Rauchens von Tabakprodukten minimieren können oder zu einer Schadensverlängerung führen. Während das britische Royal College of Physicians Rauchern E-Zigaretten als Substitut für Tabakprodukte empfiehlt, rät die Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin Rauchern von der Nutzung der E-Zigarette ab. Drei Hypothesen liegen der Schadensminimierungsstrategie zugrunde. Hypothese 1: Es wird davon ausgegangen, dass E-Zigaretten gesundheitlich weniger Schaden anrichten als Tabakzigaretten. Hypothese 2: Es wird postuliert, dass Raucher motiviert sind, von konventionellen Zigaretten auf E-Zigaretten umzusteigen. Hypothese 3: Es wird vermutet, dass E-Zigaretten ein nebenwirkungsarmes, effektives Mittel zum Rauchstopp sind. Obwohl die langfristigen gesundheitlichen Folgen des E-Zigarettenkonsums nach wie vor unbekannt sind, mehren sich die Befunde, dass E-Zigaretten toxisch wirken, schädlich für das Herz-Kreislauf-System, die Gesundheit der Atemwege und möglicherweise krebserregend sind. Bevölkerungsrepräsentative epidemiologische Erhebungen zeigen, dass drei Viertel aller aktuellen E-Zigarettennutzer in Deutschland gleichzeitig Tabak rauchen. E-Zigaretten haben in wenigen randomisierten klinischen Studien im Vergleich zu Nikotinersatzprodukten höhere Erfolgsraten. Als frei verkäufliche Konsumprodukte unter Realbedingungen findet sich in einer Vielzahl von Studien kein Vorteil für E-Zigaretten. Zudem verlängern E-Zigaretten im Vergleich zu Nikotinersatzprodukten die Nikotinabhängigkeit. Die Hypothesen der Schadensminimierungsstrategie mittels E-Zigaretten müssen nach derzeitigem Kenntnisstand als widerlegt angesehen werden. Daher erscheint es ethisch nicht unproblematisch, wenn Ärzte ihren Patienten E-Zigaretten als Substitut zum Rauchen empfehlen.

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Section: Zeitpunkt Der Interventionunclassified

Elektronische Zigaretten – Schadensminimierung oder Schadensverlängerung?

Hanewinkel

2023

Pneumologie

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“…On May 1, 2022, the Regulations on the Administration of Electronic Tobacco prohibited the use of electronic cigarettes with flavours other than tobacco tastes ( State Council Gazette, 2022 ). Pipe & Mir (2022) found that the composition of heated chemical aerosols inhaled by the human body after electron fumigation is very complex and includes nicotine, nitrosamines, carbonyl compounds, heavy metals, free radicals, reactive oxygen species, particulate matter, and “emerging chemicals of concern”, which further demonstrates the potential harm of smoking e-cigarettes. Studies have shown that smoking e-cigarettes may increase the risk of lung disease ( Cheng et al, 2022 ) and cardiovascular disease ( Fetterman et al, 2020 ; Lee et al, 2019 ) and may cause harm to the liver ( Espinoza-Derout et al, 2019 ), urinary system ( Lee et al, 2018 ), and immune system ( Martin et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Urine proteomic analysis of the rat e-cigarette model

Liu,

Shen,

Zhao

et al. 2023

PeerJ

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Background We were curious if the urinary proteome could reflect the effects of e-cigarettes on the organism. Methods Urine samples were collected from a rat e-cigarette model before, during, and after two weeks of e-cigarette smoking. Urine proteomes before and after smoking of each rat were compared individually, while the control group was set up to rule out differences caused by rat growth and development. Results Fetuin-B, a biomarker of chronic obstructive pulmonary disease (COPD), and annexin A2, which is recognized as a multiple tumour marker, were identified as differential proteins in five out of six smoking rats on day 3. To our surprise, odourant-binding proteins expressed in the olfactory epithelium were also found and were significantly upregulated. Pathways enriched by the differential proteins include the apelin signalling pathway, folate biosynthesis pathway, arachidonic acid metabolism, chemical carcinogenesis-DNA adducts and chemical carcinogenesis-reactive oxygen species. They have been reported to be associated with immune system, cardiovascular system, respiratory system, etc. Conclusions Urinary proteome could reflect the effects of e-cigarettes in rats.

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“…On May 1, 2022, the Regulations on the Administration of Electronic Tobacco prohibited the use of electronic cigarettes other than tobacco tastes. Pipe AL et al [3] found that the composition of heated chemical aerosols inhaled by the human body after electron fumigation is very complex, including nicotine, nitrosamines, carbonyl compounds, heavy metals, free radicals, reactive oxygen species, particulate matter, and "emerging chemicals of concern", which further demonstrates the potential harm of smoking e-cigarettes. Studies have shown that smoking e-cigarettes may increase the risk of lung disease [4] and cardiovascular disease [5] [6] and may cause harm to the liver [7] , urinary system [8] , and immune system [9] .…”

Section: Introduction 11 E-cigarettesmentioning

confidence: 99%

Urine proteomic analysis of the rat e-cigarette model

Liu

Shen

Zhao

et al. 2022

Preprint

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Urinary proteomics was used to investigate the potential effects of e-cigarettes on the human body. In this study, a rat e-cigarette model was constructed by smoking for two weeks and urine samples before, during, and after e-cigarette smoking were collected. Urine proteomes before-after smoking of each rat were compared individually, while the control group was set up to rule out differences caused by rat growth and development. After smoking, the differential proteins produced by rats shows strong individual variation. Fetuin-B, a biomarker of COPD, and annexin A2, which is recognized as a multiple tumor marker, were identified as the differential proteins in five out of six smoking rats on day 3. To our surprise, odorant-binding proteins expressed in the olfactory epithelium were also found and were significantly upregulated. Pathways enriched by the differential proteins shows the evidence that smoking e-cigarettes affects the immune system, cardiovascular system, respiratory system, etc., which provides clues for further exploration of the mechanism of e-cigarettes on the human body.

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E-Cigarettes Reexamined: Product Toxicity

Cited by 7 publications

References 191 publications

Elektronische Zigaretten – Schadensminimierung oder Schadensverlängerung?

Elektronische Zigaretten – Schadensminimierung oder Schadensverlängerung?

Urine proteomic analysis of the rat e-cigarette model

Urine proteomic analysis of the rat e-cigarette model

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