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Cited by 7 publications
(5 citation statements)
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References 8 publications
(11 reference statements)
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“…Finally, nutrient sensing pathways are of particular socio-economic significance as their perturbation is associated with the process of ageing and contributes to a number of age-related conditions including cancer, neurodegeneration and cardiovascular disease as highlighted in several reviews in this issue [ 182 , 183 , 184 ]. Thus, deregulation of mTORC1 has been described in cellular and organismal senescence where it can remain active even during nutrient deprivation [ 176 178 ]. This could drive uncontrolled growth, hypertrophy and chronic suppression of autophagy, all potential contributing factors in age-related pathology [ 179 181 ].…”
Section: Challenges and Future Perspectivesmentioning
confidence: 99%
“…Finally, nutrient sensing pathways are of particular socio-economic significance as their perturbation is associated with the process of ageing and contributes to a number of age-related conditions including cancer, neurodegeneration and cardiovascular disease as highlighted in several reviews in this issue [ 182 , 183 , 184 ]. Thus, deregulation of mTORC1 has been described in cellular and organismal senescence where it can remain active even during nutrient deprivation [ 176 178 ]. This could drive uncontrolled growth, hypertrophy and chronic suppression of autophagy, all potential contributing factors in age-related pathology [ 179 181 ].…”
Section: Challenges and Future Perspectivesmentioning
confidence: 99%
“…Upregulated pathways in Sin3a-LOF AT2 cells included oxidative phosphorylation, mitochondrial dysfunction, sirtuin signaling, EIF2 signaling, and mTOR signaling. Interestingly, these pathways are all linked to cellular senescence (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53).…”
Section: A Novel Mouse Model Of Conditional At2 Stem Cell Senescencementioning
confidence: 99%
“…Previously, we reported clemastine enhances autophagy while suppressing the mTOR pathway in vitro and in vivo ( Li et al, 2021 ), both of which exhibit strong interplay with cellular senescence ( Kang et al, 2011 ; Kwon et al, 2017 ; Park et al, 2020 ). Especially, suppression of mTOR plays pivotal roles in preventing cellular senescence in a way either dependent or independent autophagy ( Carroll and Korolchuk, 2017 ; Carroll et al, 2017 ; Park et al, 2020 ). Thus, we further examined whether clemastine altered mTOR activity in myelin debris-treated OPCs.…”
Section: Resultsmentioning
confidence: 99%