Dysregulation of glucose, insulin, triglyceride, blood pressure, and oxidative stress after an oral glucose tolerance test in men with abdominal obesity

Nakatsuji, Hideaki; Kishida, Ken; Kitamura, Teruo; Nakajima, Chihiro; Funahashi, Tohru; Shimomura, Iichiro

doi:10.1016/j.metabol.2009.08.013

Cited by 20 publications

(16 citation statements)

References 40 publications

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“…The OGTT is helpful in screening for postprandial hyperinsulinemia, prediabetes and diabetes. Measurement at each time point after an OGTT should be performed for a better assessment of the postprandial phenomenon (Nakatsuji et al, 2010). We found that the blood glucose level was significantly reduced by PC administration in KKAy mice during the OGTT.…”

Section: Discussionmentioning

confidence: 79%

Antidiabetic potential of phycocyanin: Effects on KKAy mice

Lin

Yang

et al. 2013

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 79%

Antidiabetic potential of phycocyanin: Effects on KKAy mice

Lin

Yang

et al. 2013

Pharmaceutical Biology

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“…Another study found that alternating standing and sitting in 30 min bouts results in modest beneficial effects on postprandial glucose responses in overweight/obese adults (Scheers et al 2012a). Lower postprandial glycemia is indicative of a more efficient response to glucose ingestion and has been shown to be inversely associated with abdominal fat deposition (Khoury et al 2010;Nakatsuji et al 2010). These physiological changes may be underlying the associations of breaks in sedentary time with abdominal obesity and should be addressed in future investigations.…”

Section: Discussionmentioning

confidence: 99%

Associations of breaks in sedentary time with abdominal obesity in Portuguese older adults

Júdice

Silva

Santos

et al. 2015

AGE

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In older adults, sedentary time is positively associated with obesity. The manner in which it is accumulated, i.e., the number of breaks in sedentary time, might be also important. We examined the crosssectional associations of breaks in sedentary time with abdominal obesity in 301 older adults (111 men and 190 women) aged 75.0 ± 6.8 years. Sedentary time (counts min −1 <100) and physical activity were objectively measured by accelerometry, worn during waking hours for at least three consecutive days. A break was defined as an interruption (≥100 counts min −1 <2020) in sedentary time while performing light intensity physical activities. Sedentary time was expressed as the number of daily breaks in sedentary time or hourly breaks in sedentary time. Abdominal obesity was defined by waist circumference (men >102 cm; women >88 cm). Using binary logistic regression analyses, the odds for abdominal obesity decreased 7 % for each additional hourly break in sedentary time in women (OR=0.93, 95 % CI: 0.87-1.00), but not men, independently of total sedentary time and moderate-to-vigorous physical activity. The odds for abdominal obesity were 3.21 times higher (p=0.039) for women in quartile 1 (<225 breaks day −1 ) of daily breaks in sedentary time compared to those in quartile 4 (>353 breaks day −1 ) of daily breaks in sedentary time.These findings indicate that older women who interrupt their sedentary time more frequently are less likely to present abdominal obesity. Public health recommendations regarding breaking-up sedentary time complementary to those for physical activity are likely to be relevant.

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“…For the purpose of the present study, serum samples that were obtained at baseline from each participant and stored promptly at -20°C without the addition of exogenous antioxidants before TBARS assay. After thawing the samples, serum levels of malondialdehyde in terms of TBARS, a marker of systemic ROS production, were measured in duplicate in each of 3,534 samples by the method of Yagi (Japan Institute for the Control of Aging, Nikken SEIL Co., Shizuoka, Japan) [15], as we [16,17] and other [18] previously reported. The selection of this parameter was based on the fact that malondialdehyde can be generated from oxidative mechanisms other than lipid peroxidation, and that TBARS is assumed to represent a composite of systemic oxidative damage products, including malondialdehyde [18].…”

Section: Methods and Proceduresmentioning

confidence: 99%

Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1,178 middle-aged Japanese men - the Amagasaki Visceral Fat Study

et al. 2011

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BackgroundCirculating thiobarbituric acid-reacting substance (TBARS) levels, a marker of systemic oxidative stress, are predictive of cardiovascular events. However, they has not been evaluated in Japanese, especially with regard to the factors that contribute to the changes in circulating TBARS levels. We investigated the cross-sectional and longitudinal relationships between circulating TBARS levels and various clinicobiochemical parameters in middle-aged men.MethodsIn this population-based study (The Amagasaki Visceral Fat Study), 1,178 Japanese male urban workers who had undergone health check-ups in 2006, 2007 and 2008 and were not on medications for metabolic disorders during the follow-up period, were enrolled. Serum TBARS levels were measured by the method of Yagi. The estimated visceral fat area (eVFA) by bioelectrical impedance was measured annually. After health check-ups, subjects received health education with lifestyle modification by medical personnel.ResultsThe number of cardiovascular risk factors (hypertension, hyperglycemia, low HDL-C, hypertriglyceridemia, hyperuricemia, hyper-LDL-C and impaired renal function) augmented with the increases in log-eVFA (p < 0.0001) and log-TBARS (p < 0.0001). The combination of TBARS and eVFA had a multiplicative effect on risk factor accumulation (F value = 79.1, p = 0.0065). Stepwise multiple regression analysis identified log-eVFA, as well as age, log-body mass index (BMI), LDL-C, log-adiponectin, γ-glutamyl transpeptidase (γ-GTP) and uric acid as significant determinants of log-TBARS. Stepwise multiple regression analysis identified one-year changes in eVFA as well as BMI, γ-GTP and estimated glomerular filtration rate (eGFR) as significant determinants of one-year change in TBARS, and biennial changes in eVFA as well as BMI and γ-GTP, eGFR as significant determinants of biennial change in TBARS.ConclusionsThe present study showed a significant cross-sectional and longitudinal correlation between TBARS and eVFA, as well as BMI and γ- GTP, eGFR. Visceral fat reduction may independently associate with the improvement in systemic ROS in middle-aged Japanese men.Trial RegistrationThe Amagasaki Visceral Fat Study UMIN000002391.

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Dysregulation of glucose, insulin, triglyceride, blood pressure, and oxidative stress after an oral glucose tolerance test in men with abdominal obesity

Cited by 20 publications

References 40 publications

Antidiabetic potential of phycocyanin: Effects on KKAy mice

Antidiabetic potential of phycocyanin: Effects on KKAy mice

Associations of breaks in sedentary time with abdominal obesity in Portuguese older adults

Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1,178 middle-aged Japanese men - the Amagasaki Visceral Fat Study

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