2020
DOI: 10.18632/aging.102650
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Abstract: Alzheimer's disease (AD) is an age-related neurodegenerative disease with unknown mechanism that is characterized by the aggregation of abnormal proteins and dysfunction of immune responses. In this study, an integrative approach employing in silico analysis and wet-lab experiment was conducted to estimate the degrees of innate immune system relevant gene expression, neurotoxic Aβ42 generation and neuronal apoptosis in normal Drosophila melanogaster and a transgenic model of AD. Results demonstrated mRNA level… Show more

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Cited by 16 publications
(8 citation statements)
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“…Median lifespan of Chd1 elav was equal to Chd1 WT/WT flies and significantly higher than that of Chd1 À/À flies (Figure 6C). Because several reports have linked elevated transcription of antimicrobial peptide genes to aging and lifespan (Landis et al, 2004;Rera et al, 2012;Wang et al, 2020), and because we had previously observed increased AMP levels in the gut of Chd1 mutant flies (Sebald et al, 2012), we also examined the expression levels of the three AMPs Metchnikowin (Mtk), Attacin C (AttC), and Drosomycin 3 (Dro3) in the abdomen of Chd1 elav and control flies. We found that the dysregulation of the AMPs in the fly abdomen was significantly attenuated (Figure 6D).…”
Section: Tor Pathway Inhibition Partially Rescues Shortened Lifespan In Chd1 Mutant Fliesmentioning
confidence: 99%
“…Median lifespan of Chd1 elav was equal to Chd1 WT/WT flies and significantly higher than that of Chd1 À/À flies (Figure 6C). Because several reports have linked elevated transcription of antimicrobial peptide genes to aging and lifespan (Landis et al, 2004;Rera et al, 2012;Wang et al, 2020), and because we had previously observed increased AMP levels in the gut of Chd1 mutant flies (Sebald et al, 2012), we also examined the expression levels of the three AMPs Metchnikowin (Mtk), Attacin C (AttC), and Drosomycin 3 (Dro3) in the abdomen of Chd1 elav and control flies. We found that the dysregulation of the AMPs in the fly abdomen was significantly attenuated (Figure 6D).…”
Section: Tor Pathway Inhibition Partially Rescues Shortened Lifespan In Chd1 Mutant Fliesmentioning
confidence: 99%
“…According to a previous study, the upregulation of innate immune molecules including AMPs rises proportionally to age and this is ascribable to the individual's increasing vulnerability to infections [46]. Congruently, healthy ageing Drosophila without the Aβ gene experienced progressively increasing AMP expressions as they age [47]. The overexpression of AMP genes in Drosophila causes more damage by inducing cytotoxic effects.…”
Section: Discussionmentioning
confidence: 99%
“…Third, Aβ is derived from APP, a general membrane protein, rather than residing solely in the CNS, and has its own physiological functions, such as its role as an antimicrobial peptide. Hence, the production and clearance of Aβ in the peripheral system ^p is complex [ 46 48 ]. Fourth, owing to its amphipathic and amphoteric structure, Aβ tends to bind with various proteins and hemocytes in blood [ 49 , 50 ].…”
Section: mentioning
confidence: 99%