Dysplasia and the natural history of cervical cancer: Early results of the Toronto cohort study

Spontaneous Regression of High-Grade Cervical Dysplasia: Effects of Human Papillomavirus Type and HLA Phenotype

“…In our patient cohort, 65 of 187 (34.8%) of the women referred for evaluation of high-grade cytology did not have histologically confirmed high-grade lesions. Narod et al followed a cohort of 70,236 women, also using cytologic diagnoses for an end point of progression to carcinoma in situ or worse (11). Again, as there was no histologic confirmation, it is difficult to extrapolate these findings to compare their clinical significance with the findings in our cohort.…”

Spontaneous Regression of High-Grade Cervical Dysplasia: Effects of Human Papillomavirus Type and HLA Phenotype

“…In our patient cohort, 65 of 187 (34.8%) of the women referred for evaluation of high-grade cytology did not have histologically confirmed high-grade lesions. Narod et al followed a cohort of 70,236 women, also using cytologic diagnoses for an end point of progression to carcinoma in situ or worse (11). Again, as there was no histologic confirmation, it is difficult to extrapolate these findings to compare their clinical significance with the findings in our cohort.…”

Reflections on Screening Mammography and the Early Detection of Breast Cancer

“…Dr. Anthony Miller has been my mentor since 1987. Our first joint paper, on screening for cervical cancer, was published in 1991 8 . I chose not to respond to individual criticisms, but instead to collect my thoughts and to try to explain why the study authors saw no benefit from screening.…”

Cervical screening in 20–24-year olds

“…The time period for women progressing from normal to dysplasia to malignancy was an average of 5.4 years. 11 A Dutch study estimated a mean duration for preclinical lesions as between 14.2 and 17.6 years and calculated a progression rate of 24% to invasive carcinoma. 12 A review of papers from 1955 to 1990 indicated progression from CIN 3 to invasion in 0-50% (more than 12% on average) with follow-up periods between one and 12 years.…”

Spontaneous Regression of High-Grade Cervical Dysplasia: Effects of Human Papillomavirus Type and HLA Phenotype

“…In our patient cohort, 65 of 187 (34.8%) of the women referred for evaluation of high-grade cytology did not have histologically confirmed high-grade lesions. Narod et al followed a cohort of 70,236 women, also using cytologic diagnoses for an end point of progression to carcinoma in situ or worse (11). Again, as there was no histologic confirmation, it is difficult to extrapolate these findings to compare their clinical significance with the findings in our cohort.…”

Reflections on Screening Mammography and the Early Detection of Breast Cancer

“…Dr. Anthony Miller has been my mentor since 1987. Our first joint paper, on screening for cervical cancer, was published in 1991 8 . I chose not to respond to individual criticisms, but instead to collect my thoughts and to try to explain why the study authors saw no benefit from screening.…”

Cervical screening in 20–24-year olds

“…The time period for women progressing from normal to dysplasia to malignancy was an average of 5.4 years. 11 A Dutch study estimated a mean duration for preclinical lesions as between 14.2 and 17.6 years and calculated a progression rate of 24% to invasive carcinoma. 12 A review of papers from 1955 to 1990 indicated progression from CIN 3 to invasion in 0-50% (more than 12% on average) with follow-up periods between one and 12 years.…”

Spontaneous Regression of High-Grade Cervical Dysplasia: Effects of Human Papillomavirus Type and HLA Phenotype

“…In our patient cohort, 65 of 187 (34.8%) of the women referred for evaluation of high-grade cytology did not have histologically confirmed high-grade lesions. Narod et al followed a cohort of 70,236 women, also using cytologic diagnoses for an end point of progression to carcinoma in situ or worse (11). Again, as there was no histologic confirmation, it is difficult to extrapolate these findings to compare their clinical significance with the findings in our cohort.…”

Reflections on Screening Mammography and the Early Detection of Breast Cancer

“…Dr. Anthony Miller has been my mentor since 1987. Our first joint paper, on screening for cervical cancer, was published in 1991 8 . I chose not to respond to individual criticisms, but instead to collect my thoughts and to try to explain why the study authors saw no benefit from screening.…”

Cervical screening in 20–24-year olds

“…The time period for women progressing from normal to dysplasia to malignancy was an average of 5.4 years. 11 A Dutch study estimated a mean duration for preclinical lesions as between 14.2 and 17.6 years and calculated a progression rate of 24% to invasive carcinoma. 12 A review of papers from 1955 to 1990 indicated progression from CIN 3 to invasion in 0-50% (more than 12% on average) with follow-up periods between one and 12 years.…”