Dysphagia in a Patient with Wegener's Granulomatosis: Case Report

Miller, Pamela G.; Santini, Celia; Freed, Mitchell J.

doi:10.1007/s004550110007

Cited by 9 publications

(5 citation statements)

References 7 publications

(8 reference statements)

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“…Oropharyngeal dysphagia, which has only previously been reported with an undetermined mechanism in one case as a later complication of generalized WG [1], was the main presenting symptom of our patient. An effective pharyngeal swallow requires effective coordination of different events driven by the nervous system, including base-of-tongue driving force, pharyngeal stripping wave, elevation of the hyoid and larynx, opening of the upper esophageal sphincter, true vocal fold closure [2].…”

Section: Discussionmentioning

confidence: 73%

Severe dysphagia in lower cranial nerve involvement as the initial symptom of Wegener's granulomatosis

Armani

Spinazzi

Andrigo

et al. 2007

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 73%

Severe dysphagia in lower cranial nerve involvement as the initial symptom of Wegener's granulomatosis

Armani

Spinazzi

Andrigo

et al. 2007

Journal of the Neurological Sciences

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“…3 In addition, a case of dysphagia owing to oropharyngeal involvement in a patient with Wegener's granulomatosis has been reported. 10 However, there are no prior cases of dysphagia owing to esophageal involvement in patients with Wegener's granulomatosis.…”

Section: Discussionmentioning

confidence: 99%

A case of Wegener's granulomatosis associated with progressive dysphagia owing to esophageal involvement

Yamaguchi¹,

Yoshioka

Ueda

et al. 2007

Mod Rheumatol

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A 52-year-old woman was admitted to our hospital with progressive dysphagia. Upper gastrointestinal endoscopy revealed esophageal stenosis and computed tomographic scan revealed symmetrical wall thickness of the thoracic esophagus. Biopsies findings from a lesion were unremarkable. However, a definitive diagnosis of Wegener's granulomatosis was based on positive anti-neutrophil cytoplasmic antibodies directed against proteinase 3 and otorhinolaryngological manifestations. Esophageal complications are rarely reported in Wegener's granulomatosis; however, clinicians should be aware of the possibility of esophageal involvement.

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“…Occasionally the gastrointestinal tract can be involved causing abdominal pain due to peritonitis, splanchnic vasculitis, and occasionally gastrointestinal bleeding [12,13]. Oropharyngeal dysphagia and odynophagia, as well as esophageal involvement, have been described in patients with GPA [14].…”

Section: Discussionmentioning

confidence: 99%

Granulomatosis with polyangiitis (GPA) in a 76-year old woman presenting with pulmonary nodule and accelerating acute kidney injury

Darwich¹,

Schnell²,

Cossey³

2020

J Clini Nephrol

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Granulomatosis with polyangiitis (GPA), a form of ANCA-associated vasculitis (AAV), is a rare disease with an often-occult presentation. It is more common in 4 th and 5 th decades of life but can be seen in all ages. This case report details a 76-year-old female presenting with abdominal pain, generalized weakness, and malaise, who was found to have pulmonary nodules on chest imaging. Biopsy of the lung nodule showed organizing pneumonia. Initially, antibiotics were used to treat the patient. However, she developed acute renal failure a few days after presentation and found to have positive serum C-ANCA as well as elevated ANCA-PR3 serologies. A subsequent kidney biopsy demonstrated pauci-immune necrotizing and crescentic glomerulonephritis that was consistent with GPA and the patient was started immediately on combination immunosuppressive therapy, plasmapheresis, and hemodialysis. GPA's clinical and radiological presentation can mimic other common conditions such as pneumonia, malignancy, bacterial sinusitis, pulmonary tuberculosis, sarcoidosis, and urinary tract infection. Because of this, a high level of suspicion is required for early diagnosis and treatment to alter the high mortality rate in this disease entity. All forms of ANCA-associated vasculitis (AAV) should be in the differential diagnosis for all patients presenting with multiorgan system involvement particularly in individuals with pulmonary and renal manifesations.

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Dysphagia in a Patient with Wegener's Granulomatosis: Case Report

Cited by 9 publications

References 7 publications

Severe dysphagia in lower cranial nerve involvement as the initial symptom of Wegener's granulomatosis

Severe dysphagia in lower cranial nerve involvement as the initial symptom of Wegener's granulomatosis

A case of Wegener's granulomatosis associated with progressive dysphagia owing to esophageal involvement

Granulomatosis with polyangiitis (GPA) in a 76-year old woman presenting with pulmonary nodule and accelerating acute kidney injury

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