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Cited by 7 publications
(5 citation statements)
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References 8 publications
(6 reference statements)
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“…For example, the nervous system associated gene, APOE, important to many of neurological diseases such as Alzheimer’s and Parkinson 28 were found to be expressed specifically by macrophages, as seen in Figure 1L . Studies have shown that genetic polymorphisms in APOE protein leads to defective clearance of the Aβ plaques by macrophages 2931 . Thus, conferring macrophages as one of the key players of the disease.…”
Section: Resultsmentioning
confidence: 99%
“…For example, the nervous system associated gene, APOE, important to many of neurological diseases such as Alzheimer’s and Parkinson 28 were found to be expressed specifically by macrophages, as seen in Figure 1L . Studies have shown that genetic polymorphisms in APOE protein leads to defective clearance of the Aβ plaques by macrophages 2931 . Thus, conferring macrophages as one of the key players of the disease.…”
Section: Resultsmentioning
confidence: 99%
“…In fact, a dysfunction of the macrophage system is observed in AD patients, in particular, the impaired ability of Aβ phagocytosis [64][65][66][67]. It is an interesting fact that adiponectin regulates the M1/M2 polarization phenotype of peripheral macrophages [30,68], and this polarization plays a role in the regulation of Aβ oligomers phagocytosis in AD [69,70].…”
Section: Discussionmentioning
confidence: 99%
“…In depression, ROS are capable of producing membrane damage, changes in the inner proteins affecting their structure and function, lipids denaturation, and structural damage to DNA in the brain [28][29][30]. ROS also contributes to the gradual deterioration of macrophages functional characteristics in neurodegenerative diseases [31][32][33]. Oxidative imbalance produces reactive carbonyls that influence the ECM extracellular matrix environment of macrophages, decreasing their phagocytic activity towards apoptotic cells [34].…”
Section: Discussionmentioning
confidence: 99%