volume 93, issue 0, P3-P-272 2020
DOI: 10.1254/jpssuppl.93.0_3-p-272
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Abstract: Microglia play important roles in maintaining brain homeostasis. Dysfunction of microglia is implicated in various neurological disorders. Recent studies have shown that microglia are also involved in the metabolic diseases. In hyperlipidemia, long chain fatty acids induced microglial activation, resulting in exacerbation of the disease. However, the involvement of hyperglycemia in microglial functions has not been clarified. First, we investigated the effect of high glucose on primary mouse microglia. Chronic…

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