Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers

Sohail, Muhammad; Hedin, Lars O.; Al-Asmakh, Maha

doi:10.2147/dmso.s325073

Cited by 11 publications

(10 citation statements)

References 53 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, our methodology focused on the search for non-fastidious potential pathogenic and opportunistic bacteria, and, second, a higher diversity of microorganisms is commonly associated with healthy states. In fact, cardiovascular diseases seem to be associated with a loss of microbial diversity of potential pathogenic taxa, which may be translated by the predominance of a certain genus of bacteria [ 41 , 42 ]. Maternal diversity may consequently impact the child’s health.…”

Section: Discussionmentioning

confidence: 99%

Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

et al. 2023

View full text Add to dashboard Cite

In early life, maternal factors are of the utmost relevance for oral microbiome acquisition and maturation. Therefore, our study explored the impact of maternal factors, such as saliva and breastmilk colonization, cardiovascular risk factors (CRF), type of delivery, oral health, and caregiving habits on the prevalence of potential pathogenic and opportunistic oral bacteria in early life. A total of 26 healthy mothers, 23 mothers with CRF, and their 50 children were included and samples (child’s oral swabs, mother’s saliva, and breastmilk) were collected 4 to 12 weeks after delivery and inoculated in selective and differential media for detection of non-fastidious Gram-negative and Gram-positive bacteria to isolate potential pathogenic and opportunistic bacteria identified by MALDI-TOF MS (414 isolates). Within mother–child dyads, the same species were identified in 86% of the pairs and potential pathogenic microorganisms from the Staphylococcaceae and Enterobacteriaceae families were found to be statistically significantly concordant between mother–child samples, particularly in the healthy group. Staphylococcus saprophyticus and Stenotrophomonas maltophilia oral colonization in mother–child pairs were associated with the presence of CRF. Breastfeeding was related to the early life oral colonization of Staphylococcus epidermidis in children from healthy mothers and C-section was associated with higher diversity of pathogens, independent of cardiovascular status (p = 0.05). This study reveals the presence of potential oral opportunistic and pathogenic bacteria in early life and highlights the importance of maternal factors in its acquisition.

show abstract

Section: Discussionmentioning

confidence: 99%

Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Previous study compared clinical chemistry measurements of enzymes, metabolites between patients with HTN and controls, 49 few studies used metabolomic to analysis metabolites in patients with HTN, especially OSA related HTN. Ultra-high-performance liquid chromatography was used for metabolomic analysis to screen for differential metabolites in our study, including indicators that are not routinely used in clinical.…”

Section: Discussionmentioning

confidence: 99%

Altered Salivary Microbiota in Patients with Obstructive Sleep Apnea Comorbid Hypertension

Chen¹,

Chen²,

Feng³

et al. 2022

NSS

View full text Add to dashboard Cite

Purpose Microorganisms contribute to the pathogenesis of obstructive sleep apnea (OSA)-associated hypertension (HTN), while more studies focus on intestinal microbiome. However, the relationship between oral microbiota and OSA-associated HTN has yet to be elucidated. This study aimed to identify differences in salivary microbiota between patients with OSA comorbid HTN compared with OSA patients, and furthermore evaluate the relationship between oral microbiome changes and increased blood pressure in patients with OSA. Patients and Methods This study collected salivary samples from 103 participants, including 27 healthy controls, 27 patients with OSA, 23 patients with HTN, and 26 patients with OSA comorbid HTN, to explore alterations of the oral microbiome using 16S rRNA gene V3-V4 high-throughput sequencing. And ultra-high-performance liquid chromatography was used for metabolomic analysis. Results Alpha- and beta-diversity analyses revealed a substantial difference in community structure and diversity in patients with OSA comorbid HTN compared with patients with OSA or HTN. The relative abundance of the genus Actinomyces was significantly decreased in patients with HTN compared with healthy controls, and those with OSA concomitant HTN compared with the patients in OSA, but was not significantly different between patients with OSA and healthy controls. Linear discriminant analysis effect size and variance analysis also indicated that the genera Haemophilus, Neisseria , and Lautropia were enriched in HTN. In addition, Oribacterium was an unique taxa in the OSA comorbid HTN group compared with the control group. Metabolomic analysis of saliva identified compounds associated with cardiovascular disease in patients with OSA comorbid HTN.2-hydroxyadenine, was significantly increased in the group of patients with OSA compared with controls, and L-carnitine was significantly decreased in patients with OSA comorbid HTN compared with OSA patients. Conclusion This study highlighted noninvasive biomarkers for patients with OSA comorbid HTN. As the first study to find alterations of the salivary microbiome in patients with OSA comorbid HTN, it may provide a theoretical foundation for clinical diagnosis and treatment of this condition.

show abstract

“…In agreement with previous studies ( Dewhirst et al., 2010 ) in the OM composition, the most abundant phyla were Firmicutes, Bacteroidetes, Proteobacteria, Fusobacteria , and Actinobacteria. OM dysbiosis has been associated with various oral (such as gingivitis, and periodontitis) and systemic diseases, including cardiovascular disease ( Sohail et al., 2021 ). Furthermore, the presence of Firmicutes , and especially the genera Granullicatella and Streptococcus , in the oral cavity has been positively correlated with BMI, poor oral hygiene, and obesity.…”

Section: Discussionmentioning

confidence: 99%

Cytokine and microbiota profiles in obesity-related hypertension patients

Aguirre-García,

Amedei,

Hernández-Ruiz

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundSystemic arterial hypertension is linked to a heightened risk of cardiovascular diseases on a global scale. In Mexico, nearly half of adults in vulnerable conditions experience hypertension. Imbalance in the oral and intestinal microbiota composition has been observed in patients with hypertension, documented by a decrease of bacteria producing short-chain fatty acids, which play a critical role in blood pressure regulation.AimTo examine the cytokines’ profile and assess the characteristics of oral and gut microbiota in obesity-related hypertension in Mexican patients.MethodsA cross-sectional, observational, and analytical study was carried out. Twenty-two patients were categorized by their body mass index (BMI) as overweight and obese, and the diagnosis of primary hypertension. DNA from supragingival dental plaque and feces samples was used to carry out 16S rRNA sequencing. Additionally, 13 cytokines were quantified.ResultsIn the oral microbiota, Kluyvera was found to be significantly enriched in obese compared to overweight patients. Instead, the gut microbiota was dominated by Firmicutes. However, the correlation between certain genera and proinflammatory cytokines was noted.ConclusionThis exploratory study provides insights into the complex relationship between the oral and gut microbiota and their association with systemic inflammation in obesity-related hypertension.

show abstract

Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers

Cited by 11 publications

References 53 publications

Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

Altered Salivary Microbiota in Patients with Obstructive Sleep Apnea Comorbid Hypertension

Cytokine and microbiota profiles in obesity-related hypertension patients

Contact Info

Product

Resources

About