Dysbiosis of the gut microbiome impairs mouse skeletal muscle adaptation to exercise

Valentino, Taylor; Vechetti, Ivan J.; Mobley, C. Brooks; Dungan, Cory M.; Golden, Lesley R.; Goh, Jensen; McCarthy, John J.

doi:10.1113/jp281788

Cited by 26 publications

(32 citation statements)

References 66 publications

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“…PoWeR is an easy-to-deploy and effective combined training modality for inducing pronounced skeletal muscle adaptations in aged mice. Compared to young C57BL/6 mice, 23 , 24 , 32 old mice run less (10–12 km/night versus 6-8 km/night) on a wheel that is only weighted to 5 g (as opposed to 6 g). Nevertheless, fiber type transitions, muscle fiber hypertrophy, satellite cell proliferation, and myonuclear accretion were still similar in magnitude between young and aged.…”

Section: Discussionmentioning

confidence: 96%

Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise

et al. 2022

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Murine exercise models can provide information on factors that influence muscle adaptability with aging, but few translatable solutions exist. Progressive weighted wheel running (PoWeR) is a simple, voluntary, low-cost, high-volume endurance/resistance exercise approach for training young mice. In the current investigation, aged mice (22-month-old) underwent a modified version of PoWeR for 8 weeks. Muscle functional, cellular, biochemical, transcriptional, and myonuclear DNA methylation analyses provide an encompassing picture of how muscle from aged mice responds to high-volume combined training. Mice run 6-8 km/day, and relative to sedentary mice, PoWeR increases plantarflexor muscle strength. The oxidative soleus of aged mice responds to PoWeR similarly to young mice in every parameter measured in previous work; this includes muscle mass, glycolytic-to-oxidative fiber type transitioning, fiber size, satellite cell frequency, and myonuclear number. The oxidative/glycolytic plantaris adapts according to fiber type, but with modest overall changes in muscle mass. Capillarity increases markedly with PoWeR in both muscles, which may be permissive for adaptability in advanced age. Comparison to published PoWeR RNA-sequencing data in young mice identified conserved regulators of adaptability across age and muscles; this includes Aldh1l1 which associates with muscle vasculature. Agrn and Samd1 gene expression is upregulated after PoWeR simultaneous with a hypomethylated promoter CpG in myonuclear DNA, which could have implications for innervation and capillarization. A promoter CpG in Rbm10 is hypomethylated by late-life exercise in myonuclei, consistent with findings in muscle tissue. PoWeR and the data herein are a resource for uncovering cellular and molecular regulators of muscle adaptation with aging.

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Section: Discussionmentioning

confidence: 96%

Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise

et al. 2022

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“…35% of participants said they noticed an improvement in their muscle stiffness and recovery after sports while doing the study. As previously mentioned, a healthy gut microbiome has been shown to benefit many factors that are involved in sports performance and recovery [1][2][3]5,7,[41][42][43]. We also note that the same is true in reverse; exercise has been shown to strengthen the gut microbiome and increase biodiversity [4].…”

Section: Physical Resultsmentioning

confidence: 54%

“…Multiple studies have shown that a healthy, biodiverse gut microbiome is crucial for sports recovery and performance because it is thought to impact muscle growth [1,2], boost energy levels [3,4], strengthen bones [5], reduce inflammation [6], and improve sleep [3,7].…”

Section: Introductionmentioning

confidence: 99%

Short Communication: Could The Skin Microbiome Affect Sports Recovery And Performance?

Wallen-Russell¹,

Wallen-Russell²

2022

Preprint

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This short communication reports on the initial results of a much larger, ongoing project, the aim of which is to investigate the question: could the skin microbiome, just like the gut microbiome, play a role in sports recovery and performance – and if so, could this role be as significant a one as that played by the gut microbiome? 17 high performance college athletes addressed their skin microbiome by minimizing contact with synthetic chemicals and by using topical skin supplements, shown previously to significantly increase skin microbiome biodiversity, for two weeks after training. 76% said their skin softness improved, 35% said their muscle stiffness and recovery after sport improved, 12% said their sleep quality improved, and 100% said they would be likely to use skin supplements again. Future work will use hundreds of athletes.

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“…15,31,32 Animal experimentations indicate a bidirectional communication between gut and skeletal muscle and point out that gut microbiota is critical for optimal muscle function. 34,35 In fact, the presence of an intact gut microbiome is necessary for normal muscle adaptations to exercise 36 and to promote adequate dietary protein digestion and amino acid absorption, a critical processes to counteract sarcopenia-associated muscle protein wasting. 37,38…”

Section: Effects Of Gut Microbiota On Skeletal Muscle and Aging-relat...mentioning

confidence: 99%

Exercise–microbiota interactions in aging‐related sarcopenia

Burtscher

Ticinesi

Millet

et al. 2022

J cachexia sarcopenia muscle

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Dysbiosis of the gut microbiome impairs mouse skeletal muscle adaptation to exercise

Abstract: support-information-section).

Cited by 26 publications

References 66 publications

Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise

Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise

Short Communication: Could The Skin Microbiome Affect Sports Recovery And Performance?

Exercise–microbiota interactions in aging‐related sarcopenia

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