Dysbiosis of Gut Microbiota (DOGMA) – A novel theory for the development of Polycystic Ovarian Syndrome

Tremellen, Kelton; Pearce, Karma

doi:10.1016/j.mehy.2012.04.016

Cited by 231 publications

(210 citation statements)

References 98 publications

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“…While primarily an ailment of the gut, dysbiosis can have systemic effects due to increased permeability of the intestinal mucosa [83]. This can result in bacterial products such as lipopolysaccharide to enter systemic circulation resulting in systemic and local tissue inflammation at distant sites including the bone (Fig 4) [84, 85].…”

Section: ) Mechanisms Of Probiotic Prevention Of Bone Pathophysiologymentioning

confidence: 99%

Probiotics in Gut-Bone Signaling

Schepper

Irwin

Kang

et al. 2017

Advances in Experimental Medicine and Biology

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The intestinal environment is linked to an array of conditions and diseases, including osteoporosis. Human and animal studies indicate that probiotics can benefit intestinal health and may provide a useful therapeutic to prevent and/or treat bone loss. Probiotics are defined as live microorganisms that when administered in adequate amounts will confer a health benefit on the host. In this review, we will focus on 1) probiotics (definition, history, nomenclature, types), 2) the effects of probiotics on bone health and 3) mechanisms of probiotic prevention of bone pathologies.

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Section: ) Mechanisms Of Probiotic Prevention Of Bone Pathophysiologymentioning

confidence: 99%

Probiotics in Gut-Bone Signaling

Schepper

Irwin

Kang

et al. 2017

Advances in Experimental Medicine and Biology

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“…Recent studies have found that the profiles of bacterial abundance exhibit similarities between the orders Clostridales and Bacteroidales . 22 , 31 , 32 Obese and non-obese women with PCOS had enriched Bacteroidetes and a decreased abundance of Akkermansia (of the phylum Verrucomicrobia ), Alistipes, Corprococcus , and Ruminococcus . 33 Akkermansia prevalence decreased in diet-induced obesity rats and was inversely correlated with peripheral inflammation in adipose tissue.…”

Section: Introductionmentioning

confidence: 99%

Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis

et al. 2018

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Background: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant. Therefore, we hypothesized that the hypertension seen in PCOS has early origins in gut dysbiosis caused by in utero exposure to excess androgen. We investigated this hypothesis with a model of prenatal androgen (PNA) exposure and maternal hyperandrogenemia by single-injection of testosterone cypionate or sesame oil vehicle (VEH) to pregnant dams in late gestation. We then completed a gut microbiota and cardiometabolic profile of the adult female offspring. Results: The metabolic assessment revealed that adult PNA rats had increased body weight and increased mRNA expression of adipokines: adipocyte binding protein 2, adiponectin, and leptin in inguinal white adipose tissue. Radiotelemetry analysis revealed hypertension with decreased heart rate in PNA animals. The fecal microbiota profile of PNA animals contained higher relative abundance of bacteria associated with steroid hormone synthesis, Nocardiaceae and Clostridiaceae, and lower abundance of Akkermansia, Bacteroides, Lactobacillus, Clostridium. The PNA animals also had an increased relative abundance of bacteria associated with biosynthesis and elongation of unsaturated short chain fatty acids (SCFAs). Conclusions: We found that prenatal exposure to excess androgen negatively impacted cardiovascular function by increasing systolic and diastolic blood pressure and decreasing heart rate. Prenatal androgen was also associated with gut microbial dysbiosis and altered abundance of bacteria involved in metabolite production of short chain fatty acids. These results suggest that early-life exposure to hyperandrogenemia in daughters of women with PCOS may lead to long-term alterations in gut microbiota and cardiometabolic function.

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“…Согласно полу-ченным данным, больные с СПКЯ имеют меньшее разнообразие и изменённый филогенетический про-филь микробиоты каловых масс. Было выяснено, что последствия дисбактериоза кишечника, связанного с диетой, влияют на развитие хронического воспале-ния, инсулинрезистентности и СПКЯ [21]. В другом исследовании у больных с СПКЯ зафиксированы изменения в бактериальном составе и структуре микробиома фекалий и слюны, по сравнению со здо-ровой группой исследуемых.…”

Section: обзор литературы посвящён проблеме синдрома поликистозных яиunclassified

Polycystic Ovary Syndrome and Periodontal Status: A Literature Review

Игумнов¹,

Igumnov²,

Kuz'min³

et al. 2018

Acta Biomedica Scientifica

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Синдром поликистозных яичников (СПКЯ) явля-ется одной из наиболее актуальных проблем гинеко-логической эндокринологии. Его частота составляет 5-10 % среди женщин репродуктивного возраста, око-ло 30 % среди пациенток гинеколого-эндокринологи-ческого профиля, а в структуре эндокринного беспло-дия достигает 75 % [2]. Однако этиология и патогенез СПКЯ остаются до конца не изученными, несмотря на большое число исследований, посвящённых данной проблеме [3]. Большинство исследователей считают СПКЯ многофакторной патологией, возможно, гене-тически детерминированной, в патогенезе которой участвуют центральные механизмы нарушений гонадотропной функции гипофиза, местные яични-ковые факторы, экстраовариальные эндокринные и метаболические нарушения, определяющие клини-ческую симптоматику и морфологические изменения яичников [1,5,6,14,18].Развитие СПКЯ у женщин сопровождается раз-личными патологическими состояниями. По данным ряда исследований, у женщин с СПКЯ значительно чаще, чем в целом в популяции, встречаются сахарный

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Dysbiosis of Gut Microbiota (DOGMA) – A novel theory for the development of Polycystic Ovarian Syndrome

Cited by 231 publications

References 98 publications

Probiotics in Gut-Bone Signaling

Probiotics in Gut-Bone Signaling

Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis

Polycystic Ovary Syndrome and Periodontal Status: A Literature Review

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