Dysbiosis of Gut Microbiota and Intestinal Barrier Dysfunction in Pigs with Pulmonary Inflammation Induced by Mycoplasma hyorhinis Infection

Zhang, Ying-Ying; Gao, Yuan; Wang, Jia; Feng, Zhixin; Zhong, Zhaoxin; Bao, Hongduo; Xiong, Qiyan; Wang, Ran

doi:10.1128/msystems.00282-22

Cited by 11 publications

(15 citation statements)

References 55 publications

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“…Alteration of the gut microbiota is related to intestinal permeability (Kang et al, 2022 ; Koutoukidis et al, 2022 ; Zhang et al, 2022 ). The intestinal barrier is key to blocking toxic substances and maintaining normal intestinal homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Humic acids alleviate dextran sulfate sodium-induced colitis by positively modulating gut microbiota

et al. 2023

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Humic acids (HAs) are natural polymers with diverse functional groups that have been documented and utilized in traditional Chinese medicine. Dextran sulfate sodium (DSS)-induced colitis has been used as a model to study inflammatory bowel disease. In this research, we investigate the effect of HAs on ameliorating DSS-induced colitis in mice. Our aim here was to investigate if HAs could be a remedy against colitis and the mechanisms involved. The results show that HAs facilitated a regain of body weight and restoration of intestinal morphology after DSS-induced colitis. HAs treatment alters the community of gut microbiota with more Lactobacillus and Bifidobacterium. Changes in bacterial community result in lower amounts of lipopolysaccharides in mouse sera, as well as lower levels of inflammatory cytokines through the Toll-like receptor 4 (TLR4)-NF-κB pathway. HAs also promoted the expression of tight junction proteins, which protect the intestinal barrier from DSS damage. Cell experiments show that HAs display an inhibitory effect on DSS growth as well. These results suggest that HAs can alleviate colitis by regulating intestinal microbiota, reducing inflammation, maintaining mucosal barriers, and inhibiting pathogen growth. Thus, HAs offer great potential for the prevention and treatment of colitis.

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Section: Discussionmentioning

confidence: 99%

Humic acids alleviate dextran sulfate sodium-induced colitis by positively modulating gut microbiota

et al. 2023

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“…This was confirmed by the results of a previous study: M. hyorhinis infection had a significant impact on the growth performance of pigs, as it resulted in a reduction in their average daily weight gain. 7 Genera with relative abundance wileyonlinelibrary.com/jsfa greater than 1% include Prevotella, Clostridium, Bacteroides, Ruminococcus, Oscillibacter, Roseburia, and Eubacterium. These genera are the most abundant and dominant bacteria in all pigs.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Existing studies have reported that it is a common cause of pneumonia, polyarthritis, and arthritis, [4][5][6] and also can lead to growth retardation. 7 Moreover, M. hyorhinis usually coinfects with a variety of other pathogens in swine production. 8 The pathogenic mechanism of inflammatory diseases caused by M. hyorhinis infection remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Perturbations of gut microbiome and metabolome of pigs infected with Mycoplasma hyorhinis

et al. 2023

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BackgroundMycoplasma hyorhinis is a prevalent respiratory pathogen in swine, causing significant economic loss to pig producers. There is growing evidence that respiratory pathogen infections have a large impact on intestinal microecology. To study the effect of M. hyorhinis infection on gut microbial composition and metabolome profile, pigs were infected with M. hyorhinis. Metagenomic sequencing analysis was performed of fecal samples and a liquid chromatography/tandem mass spectrometry (LC–MS/MS) analysis of gut digesta was made.ResultsPigs infected with M. hyorhinis had enriched Sutterella and Mailhella, and depleted Dechloromonas, Succinatimonas, Campylobacter, Blastocystis, Treponema, and Megasphaera. The pigs infected with M. hyorhinis also had greater abundances of bacterium_0_1xD8_71, Ruminococcus_sp__CAG_353, Firmicutes_bacterium_CAG_194, Firmicutes_bacterium_CAG_534, bacterium_1xD42_87, and lower abundances of Chlamydia_suis, Megasphaera_elsdenii, Treponema_porcinum, Bacteroides_sp__CAG_1060, Faecalibacterium_prausnitzii. Metabolomic analysis revealed that some lipids and lipid‐like molecules increased in the small intestine, whereas most lipids and lipid‐like molecule metabolites decreased in the large intestine. These altered metabolites induce changes in intestinal sphingolipid metabolism, amino acid metabolism, and thiamine metabolism.ConclusionThese findings demonstrate that infection with M. hyorhinis can alter the gut microbial composition and metabolite structure in pigs, which may further affect amino acid metabolism and lipid metabolism in the intestine. © 2023 Society of Chemical Industry.

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“…The gut microbiota community is composed of a specific ratio of various bacterial species, in which species alternately restrict each other’s function and depend on each other to create an ecological balance. An imbalance in the microbiota community causes gut dysbiosis, which contributes to the development of diseases in pigs, including respiratory infection ( 73 ), postweaning diarrhea ( 74 ), impairment of the gut–liver axis ( 75 ), and intestinal barrier dysfunction ( 76 ). The fact that DF can alter microbiota composition indicates that the gut microbiota can be manipulated by DF as a way of improving the health of pigs.…”

Section: Df-microbiota Interaction and Intestinal Healthmentioning

confidence: 99%

The interaction between dietary fiber and gut microbiota, and its effect on pig intestinal health

Hu¹,

Diao

et al. 2023

Front. Immunol.

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Intestinal health is closely associated with overall animal health and performance and, consequently, influences the production efficiency and profit in feed and animal production systems. The gastrointestinal tract (GIT) is the main site of the nutrient digestive process and the largest immune organ in the host, and the gut microbiota colonizing the GIT plays a key role in maintaining intestinal health. Dietary fiber (DF) is a key factor in maintaining normal intestinal function. The biological functioning of DF is mainly achieved by microbial fermentation, which occurs mainly in the distal small and large intestine. Short-chain fatty acids (SCFAs), the main class of microbial fermentation metabolites, are the main energy supply for intestinal cells. SCFAs help to maintain normal intestinal function, induce immunomodulatory effects to prevent inflammation and microbial infection, and are vital for the maintenance of homeostasis. Moreover, because of its distinct characteristics (e.g. solubility), DF is able to alter the composition of the gut microbiota. Therefore, understanding the role that DF plays in modulating gut microbiota, and how it influences intestinal health, is essential. This review gives an overview of DF and its microbial fermentation process, and investigates the effect of DF on the alteration of gut microbiota composition in pigs. The effects of interaction between DF and the gut microbiota, particularly as they relate to SCFA production, on intestinal health are also illustrated.

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Dysbiosis of Gut Microbiota and Intestinal Barrier Dysfunction in Pigs with Pulmonary Inflammation Induced by Mycoplasma hyorhinis Infection

Cited by 11 publications

References 55 publications

Humic acids alleviate dextran sulfate sodium-induced colitis by positively modulating gut microbiota

Humic acids alleviate dextran sulfate sodium-induced colitis by positively modulating gut microbiota

Perturbations of gut microbiome and metabolome of pigs infected with Mycoplasma hyorhinis

The interaction between dietary fiber and gut microbiota, and its effect on pig intestinal health

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